The α v β 1 integrin plays a critical in vivo role in tissue fibrosis

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Items 201–300 of 314

1. TGF-β1 Drives Integrin-Dependent Pericyte Migration and Microvascular Destabilization in Fibrotic Disease
   Amanda S. Pellowe, Michelle J. Wu, Tae-Yun Kang, Tracy D. Chung, Adrian Ledesma-Mendoza, Erica L. Herzog, Andre Levchenko, Ian D. Odell, John Varga, Anjelica L. Gonzalez · 2024 · American Journal Of Pathology
2. Airway stenosis: classification, pathogenesis, and clinical management
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3. One integrin to rule them all?
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4. Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification
   Imran S. Khan, Christopher Molina, Xin Ren, Vincent C. Auyeung, Max Cohen, Tatsuya Tsukui, Amha Atakilit, Dean Sheppard · 2024 · eLife
5. Role of CD98 in liver disease
   Brandon S.B. Canup, Heliang Song, Hamed Laroui · 2020 · Annals of Hepatology
6. αV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo
   Kathleen K. Catignas, Luciana Romina Frick, Marta Pellegatta, Edward L. Hurley, Zachary Kolb, Kathryn Addabbo, Joseph H. McCarty, Richard O. Hynes, Arjan van der Flier, Yannick Poitelon et al. · 2020 · Glia
7. Therapeutic molecular targets of SSc-ILD
   Yun Zhang, Jörg H. W. Distler · 2020 · Journal of Scleroderma and Related Disorders
8. Therapeutic Prospects of αv Integrins Inhibition in Fibrotic Lung Diseases and Carcinogenesis
   E. L. Golovina, Veronika Vladimirovna Kochubey, Marina Alekseevna Shabanova, Darya Maksimovna Chekhvalova, V. A. Serebryakova, Е. G. Skurikhin, Ольга Евгеньевна Ваизова, S. Morozov, Aslan Amirkhanovich Kubatiev, А. М. Дыгай · 2025 · International Journal of Molecular Sciences
9. Drugs targeting CTGF in the treatment of pulmonary fibrosis
   Yudan Qiu, Yueyue Que, Zheyu Ding, Shanshan Zhang, Rong Wei, Jianing Xia, Yingying Lin · 2024 · Journal of Cellular and Molecular Medicine
10. Recent advances in positron emission tomography for detecting early fibrosis after myocardial infarction
    Qiuyan Wu, Jialin Song, Wenyan Liu, Li Li, Sijin Li · 2024 · Frontiers in Cardiovascular Medicine
11. Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications
    Toyoshi Yanagihara, Ciaran Joseph Scallan, Kjetil Ask, Martin R.J. Kolb · 2021 · Expert Opinion on Therapeutic Targets
12. Therapeutic targets in fibrotic pathways
    Travis Lear, Bill B. Chen · 2016 · Cytokine
13. The Multiple Faces of Integrin–ECM Interactions in Inflammatory Bowel Disease
    Valentina Garlatti, Sara Lovisa, Silvio Danese, Stefania Vetrano · 2021 · International Journal of Molecular Sciences
14. Integrin activating molecule-talin1 promotes skin fibrosis in systemic sclerosis
    Dan Xu, Xiandun Yuan, Li Zhao, Rong Mu · 2024 · Frontiers in Immunology
15. Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness
    Aparna Sundaram, Chun Chen, Nilgun Isik Reed, Sean Liu, Seul Ki Yeon, Joel E. McIntosh, You‐Zhi Tang, Hyunjun Yang, Marc Adler, Richard T. Beresis et al. · 2020 · Bioorganic & Medicinal Chemistry Letters
16. The Design of Potent, Selective and Drug‐Like RGD αvβ1 Small‐Molecule Inhibitors Derived from non‐RGD α4β1 Antagonists
    Richard J. D. Hatley, Tim N. Barrett, Robert J. Slack, Morag E. Watson, Daniel J. Baillache, Anna Gruszka, Yoshiaki Washio, James E. Rowedder, Péter Pogány, Sandeep Pal et al. · 2019 · ChemMedChem
17. Exploring the Role of Biomarkers Associated with Alveolar Damage and Dysfunction in Idiopathic Pulmonary Fibrosis—A Systematic Review
    Alexandra-Simona Zamfir, Mihai Zabara, Raluca Ioana Arcana, Andrei Tudor Cernomaz, Andreea Zabara-Antal, Dragoș Traian Marius Marcu, Antigona Carmen Trofor, Carmen Lăcrămioara Zamfir, Radu Adrian Crișan-Dabija · 2023 · Journal of Personalized Medicine
18. Role of β1 integrin in thrombocytopoiesis
    Maria Mazzarini, Paola Verachi, Fabrizio Martelli, Anna Ritá Migliaccio · 2021 · Faculty Reviews
19. Non-small-cell lung cancer cells combat epidermal growth factor receptor tyrosine kinase inhibition through immediate adhesion-related responses
    Hsian-Yu Wang, Kai-Hsuan Wang, Ching‐Ping Tseng, Feng-Chi Chen, John T.-A. Hsu, Min-Kung Hsu · 2016 · OncoTargets and Therapy
20. SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model
    Xiaodong Zou, Tong Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye et al. · 2025 · Cell Death Discovery
21. Macrophage amphiregulin-pericyte TGF-β axis: a novel mechanism of the immune system that contributes to wound repair
    Hong Huang, Kai Yin, Huifang Tang · 2020 · Acta Biochimica et Biophysica Sinica
22. New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ
    Sébastien This, Helena Païdassi · 2022 · Frontiers in Immunology
23. Microbial Translocation Disorders: Assigning an Etiology to Idiopathic Illnesses
    Adonis Sfera, Sabine Hazan, Carolina A. Klein, Carlos Manuel Zapata-Martín del Campo, Sarvin Sasannia, Johnathan J. Anton, Leah Rahman, Christina V. Andronescu, Dan O. Sfera, Zisis Kozlakidis et al. · 2023 · Applied Microbiology
24. Fibrotic lung ECM upregulates SDC4/integrin-αvβ1 interaction and the interfering peptide SDC487-131 and its derivative peptides alleviate pulmonary fibrosis
    Lihua Zhu, Lingfeng Xie, Yupeng Zhi, Yihao Huang, Hongkui Chen, Zibin Chen, Jinsheng Hong, Yansong Guo, Chun Chen · 2025 · Regenerative Biomaterials
25. Integrin Axis Regulates Airway Biophysical Dysfunction in Idiopathic Pulmonary Fibrosis
    Ian T. Stancil, Jacob E. Michalski, David A. Schwartz · 2022 · American Journal of Respiratory Cell and Molecular Biology
26. Integrins in biliary injury and fibrosis
    Johanna R Schaub, Jennifer Y. Chen, Scott Turner · 2024 · Current Opinion in Gastroenterology
27. Importance of integrin transmembrane helical interactions for antagonistic versus agonistic ligand behavior: Consequences for medical applications
    Ute Reuning, Vincenzo Maria D’Amore, Kairbaan Hodivala‐Dilke, Luciana Marinelli, Horst Kessler · 2025 · Bioorganic Chemistry
28. New tools to target an elusive integrin
    Katie Kingwell · 2015 · Nature Reviews Drug Discovery
29. The formin DAAM1 regulates the deubiquitinase activity of USP10 and integrin homeostasis
    Andrew T. Phillips, Edward F. Boumil, Arunkumar Venkatesan, Christine Tilstra-Smith, Nileyma Castro, Barry E. Knox, Jessica L. Henty-Ridilla, Audrey M. Bernstein · 2023 · European Journal of Cell Biology
30. USP10 Promotes Fibronectin Recycling, Secretion, and Organization
    Andrew T. Phillips, Edward F. Boumil, Nileyma Castro, Arunkumar Venkatesan, Eugenio Gallo, Jarrett Adams, Sachdev S. Sidhu, Audrey M. Bernstein · 2021 · Investigative Ophthalmology & Visual Science
31. Loss of RhoE Function in Dermatofibroma Promotes Disorganized Dermal Fibroblast Extracellular Matrix and Increased Integrin Activation
    Sofia Endzhievskaya, Chao‐Kai Hsu, Hsing‐San Yang, Hsin‐Yu Huang, Yu‐Chen Lin, Yi‐Kai Hong, John Y.W. Lee, Alexandros Onoufriadis, Takuya Takeichi, Julia Yu‐Yun Lee et al. · 2023 · Journal of Investigative Dermatology
32. ILC3s mediate intestinal immune-epithelial interactions via TGF-β1 activation
    Diana Coman, John W. Bassett, Isabelle Coales, Ainize Peña‐Cearra, Emily Read, Emma Højmose Kromann, Daniel Brice, Zuzanna Małgorzata Łukasik, Helena Païdassi, Matthew R. Hepworth et al. · 2025 · Mucosal Immunology
33. Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis
    Jiazhen Wang, Ru Wang, Yang Liu, Yicun Li, Peng Xian, Yuanhang Zhang, Xinning Zhang, Jiayi Wang, Chuangeng Tu, Haitao Zhang et al. · 2026 · Science Translational Medicine
34. MiR-122 promotes metastasis of hepatoma cells by modulating RBM47-integrin alpha V-TGF-beta signaling
    Lijun Mao, Hanru Yang, Ning Huang, Yao Li, Ye Sang, Chunxian Zeng · 2025 · PLoS ONE
35. Mechanistic insights into the treatment of pulmonary fibrosis with bioactive components from traditional chinese medicine via matrix stiffness-mediated EMT
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36. Selective inhibition of long isoforms of phosphodiesterase 4D mitigates liver fibrosis in mouse models
    Jeonghan Kim, Heeeun Yoon, Seoung Chan Joe, Antoine Smith, Jinsung Park, Geunhye Hong, Ji Myeong Ha, Eun Bae Kim, Ekihiro Seki, Myung K. Kim et al. · 2025 · Journal of Clinical Investigation
37. Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice
    Zhuan Song, Ning Liu, Yu He, Jingqing Chen, Jun Li, Fengchao Wang, Zhenlong Wu · 2022 · Inflammation
38. Design and Discovery of a Potent and Selective Inhibitor of Integrin αvβ1
    Mark P. Sabat, Daniel W. Carney, Gloria Hernández‐Torres, Tony Gibson, Deepika Balakrishna, Hua Zou, Rui Xu, Chien‐Hung Chen, Ron de Jong, Douglas R. Dougan et al. · 2024 · Journal of Medicinal Chemistry
39. Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins
    Eugenio Gallo, Abdellali Kelil, Michael Haughey, Mariana Cázares-Olivera, Bradley P. Yates, Mingjun Zhang, Naiyu Wang, Levi L. Blazer, Lia Cardarelli, Jarrett Adams et al. · 2021 · Journal of Molecular Biology
40. Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis
    Markéta Jiroušková, Karel Harant, Pavel Cejnar, Srikant Ojha, Katerina Korelova, Lenka Sarnová, Eva Sticová, Christoph H. Mayr, Herbert B. Schiller, Martin Gregor · 2024 · eLife
41. Proteomic and phosphoproteomic characterisation of primary mouse embryonic fibroblasts
    Yanfang Chen, Séverine Roselli, Nikita Panicker, Joshua S. Brzozowski, David Anthony Skerrett-Byrne, Heather C. Murray, Nicole M. Verrills · 2023 · PROTEOMICS
42. Fibrosis mechanisms and updates in potential therapeutic targets in systemic sclerosis
    Xue Han, Xiuyuan Wang, Junxia Huang, Ji Young Yang · 2025 · Seminars in Arthritis and Rheumatism
43. Spatial Transcriptomics Analysis of Macrophage-to-Myofibroblast Transition in Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation
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44. Targeting the FAPα/Integrin αvβ1 complex attenuates hepatic stellate cell activation and liver fibrosis
    Chun Guan, Nuo Cheng, Yu Tong, Yifei Li, Jiayi Liu, Haishan Luo, Shihao Liu, Jihai Chen, Cong Wang · 2026 · Biochemical Pharmacology
45. Loss of stromal cell Thy-1 plays a critical role in lipopolysaccharide induced chronic lung allograft dysfunction
    Atsushi Hata, Yizhan Guo, Andrew E. Miller, Mika Hata, Zhongcheng Mei, Amir Manafi, Dongge Li, Anirban Banerjee, Eric Lazear, Christine L. Lau et al. · 2022 · The Journal of Heart and Lung Transplantation
46. Integrins in Cancer: Refocusing on the Tumor Microenvironment
    Cédric Zeltz, Ning Lü, Ritva Heljäsvaara, Donald Gullberg · 2022 · Biology of extracellular matrix
47. Integrins: Key Targets in Tissue Fibrosis and Tumor Stroma
    Devin Veerman, Jai Prakash · 2023 · Biology of extracellular matrix
48. The role of integrins in acute leukemias and potential as targets for therapy
    Helen M. Sheldrake, Amal A. M. Elsharif, L. H. Patterson, Steven D. Shnyder · 2018 · Tumor and Microenvironment
49. Chest Imaging with a Collagen-Binding Probe—A Human Hydroxyproline Assay?
    Sarah L. Khan, Daniel J. Kass · 2025 · American Journal of Respiratory and Critical Care Medicine
50. Integrin αvβ6 mediates the effects of age-related decreases in matrix stiffness on Tenon's fibroblast activation and bleb scarring in glaucoma
    Lemeng Feng, Wei Xiong, Jiayang Yin, Dongshi Guan, Hangyu Li, Jiamin Cao, Ziyi Zhu, Wenhua Zhang, Feng Zhang · 2025 · Experimental Eye Research
51. Emerging Concepts in Therapeutic Interventions for Idiopathic Pulmonary Fibrosis
    Cody A. Schott, Michael P. Mohning, Joseph C. Cooley · 2025 · Seminars in Respiratory and Critical Care Medicine
52. Collagen in Fibrotic Diseases
    Andrzej Fertala · 2026 · Sub-cellular biochemistry/Subcellular biochemistry
53. Advances in the interplay between mechanical forces and inflammatory immunity in keloid formation
    Simin Zhou, Lei Wang, Nannan Chen, Jinqiao Liu, Rongjia Zhang, Shiqi Zhou, Yiling Liu, Wenyan Zhu, Xiaodong Chen, Run Meng · 2026 · Frontiers in Immunology
54. Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis
    Zengdun Shi, Don C. Rockey · 2026 · Nature Reviews Gastroenterology & Hepatology
55. Assessment of the Functional Activities of Casein Phosphopeptides on Circulating Blood Leukocytes
    Thaís Regina Mezzomo, Cleverson Antônio Ferreira Martins, Daniela Beck da Silva Marcondes, Keylla Lençone Mischiatti, Almeriane Maria Weffort‐Santos · 2021 · International Journal of Peptide Research and Therapeutics
56. Impaired myofibroblast proliferation is a central feature of pathologic post-natal alveolar simplification
    Imran S. Khan, Christopher Molina, Xin Ren, Vincent C. Auyeung, Max Cohen, Tatsuya Tsukui, Amha Atakilit, Dean Sheppard · 2024 · eLife
57. More Velcro for the TGF-β1 straitjacket: A new antibody straps latent TGF-β1 to the matrix
    Boris Hinz · 2024 · Science Signaling
58. Rôle des intégrines dans la fibrose cardiaque
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59. Integrins
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60. Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis
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61. Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis
    Wenyu Yang, Ri Ning Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu et al. · 2025 · Advanced Science
62. Structure-Based Discovery of Potent and Selective Small-Molecule α5β1 Integrin Inhibitors for Asthma Therapy
    Richard T. Beresis, Aparna Sundaram, Hyunil Jo, Marc Adler, Zheng Wang, Joel E. McIntosh, Seul Ki Yeon, Qiuya Huang, Grace Ngo, Dean Sheppard et al. · 2025 · ACS Omega
63. Dysregulated proline metabolism contributes to retinal fibrosis in neovascular AMD: Therapeutic potential of prolyl-4-hydroxylase inhibition
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64. Conformational Preference Classification of Integrin-Binding Ligands Using Free Energy Perturbation
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65. Drug Discovery in Tissue Fibrosis
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66. Extracellular Matrix Biology Applied to the Kidney
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67. Targeting the αv Integrins in Fibroproliferative Disease
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68. Role of the Extracellular Matrix in Tumor Stroma: Barrier or Support?
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70. Targeting the extracellular matrix for NF1-associated neurofibroma treatment
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71. Targeting αv Integrins in Pancreatic Fibrosis: Progress in Resolving the Scar
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72. New tools to study the interaction between integrins and latent TGFβ1
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73. INTEGRIS-IPF: A New Hope for Tomorrow
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74. Defective insulin clearance plays a primary role in the pathogenesis of chronic kidney disease in mice with null deletion of Ceacam2 gene
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75. Editorial Commentary: Understanding Marfan syndrome, or “how not to invent the light bulb”
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76. The range and potential contribution of irreversibly adsorbed proteins on the surface of artificial implants
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77. Identification of novel targets in fibrosis
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78. Investigating Compensation of Av Integrins in LX-2 Cells in Vitro
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79. The regulation of transforming growth factor beta (TGFβ) signaling in posterior capsular opacification
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83. Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis
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86. Dynamics of compartment-specific proteomic landscapes of hepatotoxic and cholestatic models of liver fibrosis
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87. Impaired Myofibroblast Proliferation is a Central Feature of Pathologic Post-Natal Alveolar Simplification
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88. Optimised formula of Fufang Biejia Ruangan tablets alleviates renal fibrosis by suppressing matrix-stiffness–induced fibroblast activation via inhibition of integrin αVβ1 binding
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90. Additional file 2 of Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
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91. Additional file 1 of Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF
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92. Additional file 1 of Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
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93. Alveolar-Basal Intermediates Drive Pulmonary Fibrosis via Coordination of a Pro-Fibrotic Signaling Niche in Silicosis
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95. Control of adaptive immune responses by the TGFβ-activating avb8 integrins - implications for mucosal immune homeostasis and humoral immunity
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96. Identification de marqueurs membranaires spécifiques de cellules progénitrices cardiaques PW1+ par une approche multiomique
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97. Rôle du récepteur purinergique P2X4 dans l'activation des myofibroblastes au cours de la fibrogenèse hépatique
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99. Étude du rôle de l’expression de l’intégrine αvβ8 par les lymphocytes T régulateurs dans la réponse anti-tumorale
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100. Étude du blocage pharmacologique de l'intégrine alpha v (CD51) dans le développement du remodelage cardiaque induit par surcharge de pression
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