Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell–driven rejection of high-grade glioma

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Cerami, E., Gao, J., Dogrusoz, U., Gross, B. E., Sumer, S. O., Aksoy, B. A., Jacobsen, A., Byrne, C. J., Heuer, M. L., Larsson, E., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0095 · Cited by 17,455

The cancer genome atlas pan-cancer analysis project

The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J., TAPHOORN, M. J. B., Janzer, R. C., Ludwin, S. K., Allgeier, A., Fisher, B., Bélanger, K., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70025-7 · Cited by 7,980

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

The Cancer Genome Atlas Research Network (2008) · Nature · doi:10.1038/nature07385 · Cited by 7,735

The Somatic Genomic Landscape of Glioblastoma

Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016

The immune contexture in human tumours: impact on clinical outcome

Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M. J., Obenauf, A. C., Angell, H. K., Fredriksen, T., Lafontaine, L., Berger, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.003 · Cited by 4,455

Immunogenic Cell Death in Cancer Therapy

Kroemer, G., Galluzzi, L., Kepp, O., & Zitvogel, L. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-100008 · Cited by 3,303

Calreticulin exposure dictates the immunogenicity of cancer cell death

Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216

The prognostic landscape of genes and infiltrating immune cells across human cancers

Gentles, A. J., Newman, A. M., Liu, C. L., Bratman, S. V., Feng, W., Kim, D., Nair, V. S., Xu, Y., Khuong, A., Hoang, C. D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3909 · Cited by 3,163

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

Dendritic cells in cancer immunology and immunotherapy

Wculek, S. K., Cueto, F. J., Mujal, A. M., Melero, I., Krummel, M. F., & Sancho, D. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0210-z · Cited by 2,688

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

Fukumura, D., Kloepper, J., Amoozgar, Z., Duda, D. G., & Jain, R. K. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2018.29 · Cited by 2,027

The Microenvironmental Landscape of Brain Tumors

Quail, D. F., & Joyce, J. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.009 · Cited by 1,924

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Galluzzi, L., Humeau, J., Buqué, A., Zitvogel, L., & Kroemer, G. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0413-z · Cited by 1,349

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Buqué, A., Chan, T. A.-T., Coukos, G., Demaria, S., Deutsch, É., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,210

Dendritic cell-based immunotherapy

Sabado, R. L., Balan, S., & Bhardwaj, N. (2016) · Cell Research · doi:10.1038/cr.2016.157 · Cited by 942

Immunogenic cell death in cancer therapy: Present and emerging inducers

Zhou, J., Wang, G., Chen, Y., Wang, H., Hua, Y., & Cai, Z. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14356 · Cited by 733

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

Schaaf, M. B., Garg, A. D., & Agostinis, P. (2018) · Cell Death & Disease · doi:10.1038/s41419-017-0061-0 · Cited by 629

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Alzeibak, R., Mishchenko, T. A., Shilyagina, N. Y., Balalaeva, I. V., Vedunova, M. V., & Krysko, D. V. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001926 · Cited by 583

Targeting immunogenic cell stress and death for cancer therapy

Galluzzi, L., Guilbaud, E., Schmidt, D. R., Kroemer, G., & Marincola, F. M. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-00920-9 · Cited by 638

Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure

Chen, C., Ni, X., Jia, S., Liang, Y., Wu, X., Kong, D., & Ding, D. (2019) · Advanced Materials · doi:10.1002/adma.201904914 · Cited by 505

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

Donohoe, C. L., Senge, M. O., Arnaut, L. G., & Gomes-da-Silva, L. C. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.07.003 · Cited by 452

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 451

Engineered exosomes as an in situ DC-primed vaccine to boost antitumor immunity in breast cancer

Huang, L., Rong, Y., Tang, X., Yi, K., Qi, P., Hou, J., Liu, W., He, Y. Z., Gao, X., Yuan, C., et al. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01515-x · Cited by 416

Photodynamic Therapy for the Treatment and Diagnosis of Cancer–A Review of the Current Clinical Status

Gunaydin, G., Gedik, M. E., & Ayan, S. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.686303 · Cited by 402

A melanin-mediated cancer immunotherapy patch

Ye, Y., Wang, C., Zhang, X., Hu, Q., Zhang, Y., Liu, Q., Wen, D., Milligan, J. J., Bellotti, A., Huang, L., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan5692 · Cited by 382

Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles

Hou, Y., Yang, X., Liu, R., Zhao, D., Guo, C., Zhu, A., Wen, M., Liu, Z., Qu, G., & Meng, H. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s269321 · Cited by 351

Integrating next-generation dendritic cell vaccines into the current cancer immunotherapy landscape

Garg, A. D., Coulie, P. G., Van den Eynde, B. J., & Agostinis, P. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.05.006 · Cited by 340

Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication

Song, W. L., Kuang, J., Li, C., Zhang, M., Zheng, D., Zeng, X., Liu, C., & Zhang, X. (2018) · ACS Nano · doi:10.1021/acsnano.7b09112 · Cited by 313

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

Garg, A. D., More, S., Rufo, N., Meçe, O., Sassano, M. L., Agostinis, P., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1386829 · Cited by 288

Antitumour dendritic cell vaccination in a priming and boosting approach

Harari, A., Graciotti, M., Bassani‐Sternberg, M., & Kandalaft, L. E. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0074-8 · Cited by 276

Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy

Sánchez-Paulete, A. R., Teijeira, Á., Cueto, F. J., Garasa, S., Perez‐Gracia, J. L., Sánchez-Arráez, Á., Sancho, D., & Melero, I. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx237 · Cited by 278

A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Xu, C., Jiang, Y., Han, Y., Pu, K., & Zhang, R. (2021) · Advanced Materials · doi:10.1002/adma.202008061 · Cited by 236

β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

Du, L., Lee, J., Jiang, H., Wang, C., Wang, S., Zheng, Z., Shao, F., Xu, D., Xia, Y., Li, J., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20191115 · Cited by 233

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Vanmeerbeek, I., Sprooten, J., Ruysscher, D. D., Tejpar, S., Vandenberghe, P., Fucikova, J. P., Špíšek, R., Zitvogel, L., Kroemer, G., Galluzzi, L., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2019.1703449 · Cited by 231

The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy

Rufo, N., Garg, A. D., & Agostinis, P. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.07.002 · Cited by 214

Origin and Consequences of Necroinflammation

Sarhan, M., Land, W. G., Tonnus, W., Hugo, C., & Linkermann, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00041.2016 · Cited by 217

Immunotherapy for glioblastoma: the promise of combination strategies

Bausart, M., Véronique Préat, A., & Malfanti, A. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02251-2 · Cited by 205

Immunogenic Cell Death and Immunotherapy of Multiple Myeloma

del Valle, A. S., Anel, A., Naval, J., & Marzo, I. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00050 · Cited by 199

Photodynamic Therapy and Immunity: An Update

Falk‐Mahapatra, R., & Gollnick, S. O. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13253 · Cited by 201

Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

Amoozgar, Z., Kloepper, J., Ren, J. P., Tay, R. E., Kazer, S. W., Kiner, E., Krishnan, S., Posada, J. M., Ghosh, M., Mamessier, É., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22885-8 · Cited by 200

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy

Medrano, R. F. V., Hunger, A., Mendonça, S. A., Barbuto, J. A. M., & Strauss, B. E. (2017) · Oncotarget · doi:10.18632/oncotarget.19531 · Cited by 192

Necroptosis in Immuno-Oncology and Cancer Immunotherapy

Sprooten, J., Wijngaert, P. D., Vanmeerbeek, I., Martin, S., Vangheluwe, P., Schlenner, S., Krysko, D. V., Parys, J. B., Bultynck, G., Vandenabeele, P., et al. (2020) · Cells · doi:10.3390/cells9081823 · Cited by 173

Current Challenges and Opportunities of Photodynamic Therapy against Cancer

Huis in ‘t Veld, R. V., Heuts, J., Ma, S., Cruz, L. J., Ossendorp, F. A., & Jager, M. J. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020330 · Cited by 159

Research progress on morphology and mechanism of programmed cell death

Chen, Y., Li, X., Yang, M., & Liu, S. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06712-8 · Cited by 168

Covalent Organic Framework‐Supported Molecularly Dispersed Near‐Infrared Dyes Boost Immunogenic Phototherapy against Tumors

Gan, S., Tong, X., Zhang, Y., Wu, J., Hu, Y., & Yuan, A. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902757 · Cited by 152

Trial watch: dendritic cell vaccination for cancer immunotherapy

Sprooten, J., Ceusters, J., Coosemans, A., Agostinis, P., Vleeschouwer, S. D., Zitvogel, L., Kroemer, G., Galluzzi, L., & Garg, A. D. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1638212 · Cited by 151

The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T‐Cell Repertoire

Nath, S., Obaid, G., & Hasan, T. G. (2019) · Photochemistry and Photobiology · doi:10.1111/php.13173 · Cited by 146

Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death

Li, J., Gao, H., Liu, R., Chen, C., Zeng, S., Liu, Q., & Ding, D. (2020) · Science China Chemistry · doi:10.1007/s11426-020-9846-4 · Cited by 142

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

Woensel, M. V., Mathivet, T., Wauthoz, N., Rosière, R., Garg, A. D., Agostinis, P., Mathieu, V., Robert Kiss, A., Lefranc, F., Boon, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-01279-1 · Cited by 144

Chemotherapeutic and targeted drugs-induced immunogenic cell death in cancer models and antitumor therapy: an update review

Zhai, J., Gu, X., Liu, Y., Hu, Y., Jiang, Y., & Zhang, Z. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152934 · Cited by 131

Type I interferons and dendritic cells in cancer immunotherapy

(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.06.001 · Cited by 124

Immunogenic Apoptosis as a Novel Tool for Anticancer Vaccine Development

Montico, B., Nigro, A., Casolaro, V., & Col, J. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020594 · Cited by 133

PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity

Han, L., Bai, L., Qu, C., Dai, E., Liu, J., Kang, R., Zhou, D., Tang, D., & Zhao, Y. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.08.082 · Cited by 128

Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem

Zhou, F., Wang, M., Luo, T., Qu, J., & Chen, W. R. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120421 · Cited by 126

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing

Garg, A. D., Vandenberk, L., Fang, S., Fasche, T., Van Eygen, S., Maes, J., Van Woensel, M., Koks, C., Vanthillo, N., Graf, N., et al. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.15 · Cited by 120

Photodynamic therapy with redaporfin targets the endoplasmic reticulum and Golgi apparatus

Gomes-da-Silva, L. C., Zhao, L., Bezu, L., Zhou, H., Sauvat, A., Liu, P., Durand, S., Leduc, M., Souquère, S., Loos, F., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201798354 · Cited by 119

Cold Atmospheric Plasma-Treated PBS Eliminates Immunosuppressive Pancreatic Stellate Cells and Induces Immunogenic Cell Death of Pancreatic Cancer Cells

Loenhout, J. V., Flieswasser, T., Boullosa, L. F., Waele, J. D., Audenaerde, J. R. M. V., Marcq, E., Jacobs, J., Lin, A. G., Lion, E., Dewitte, H., et al. (2019) · Cancers · doi:10.3390/cancers11101597 · Cited by 122

Trial watch: Dendritic cell-based anticancer immunotherapy

Garg, A. D., Vara‐Pérez, M., Schaaf, M. B. E., Agostinis, P., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1328341 · Cited by 120

Therapeutic cancer vaccines: From initial findings to prospects

Song, Q., Zhang, C.-D., & Wu, X.-H. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.01.011 · Cited by 106

The network of immunosuppressive pathways in glioblastoma

Mangani, D., Weller, M., & Roth, P. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.12.011 · Cited by 110

Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine

Zhou, F., Yang, J., Zhang, Y., Liu, M., Lang, M. L., Li, M., & Chen, W. R. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1126 · Cited by 98

Dendritic Cell Vaccination of Glioblastoma: Road to Success or Dead End

Datsi, A., & Sorg, R. V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.770390 · Cited by 105

Radiation‐Induced Immunogenic Cell Death for Cancer Radioimmunotherapy

Liu, T., Pei, P., Shen, W., Hu, L. T., & Yang, K. (2023) · Small Methods · doi:10.1002/smtd.202201401 · Cited by 104

Trial watch: chemotherapy-induced immunogenic cell death in oncology

Sprooten, J., Laureano, R. S., Vanmeerbeek, I., Govaerts, J., Naulaerts, S., Borràs, D., Kinget, L., Fucikova, J. P., Špíšek, R., Jelinkova, L. P., et al. (2023) · OncoImmunology · doi:10.1080/2162402x.2023.2219591 · Cited by 103

Decoding immunogenic cell death from a dendritic cell perspective

Janssens, S., Rennen, S., & Agostinis, P. (2023) · Immunological Reviews · doi:10.1111/imr.13301 · Cited by 106

Dendritic Cells and Immunogenic Cancer Cell Death: A Combination for Improving Antitumor Immunity

Lamberti, M. J., Nigro, A., Mentucci, F. M., Vittar, N. B. R., Casolaro, V., & Col, J. D. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030256 · Cited by 99

Engineering challenges for brain tumor immunotherapy

Lyon, J. G., Mokarram, N., Saxena, T. K., Carroll, S. L., & Bellamkonda, R. V. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.06.006 · Cited by 102

Boosting Tumor-Specific Immunity Using PDT

Maeding, N., Verwanger, T., & Krammer, B. E. (2016) · Cancers · doi:10.3390/cancers8100091 · Cited by 94

Cancer photo-immunotherapy: from bench to bedside

Wang, M., Rao, J., Wang, M., Li, X., Liu, K., Naylor, M. F., Nordquist, R. E., Chen, W. R., & Zhou, F. (2020) · Theranostics · doi:10.7150/thno.53056 · Cited by 91

Cyclic Amplification of the Afterglow Luminescent Nanoreporter Enables the Prediction of Anti‐cancer Efficiency

Wang, Y., Song, G., Liao, S., Qin, Q., Zhao, Y., Shi, L., Guan, K., Gong, X., Wang, P., Yin, X., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202104127 · Cited by 92

Advances in immunotherapeutic research for glioma therapy

Miyauchi, J. T., & Tsirka, S. E. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8695-5 · Cited by 90

Glioblastoma vaccines: past, present, and opportunities

Xiong, Z., Raphael, I., Olin, M. R., Okada, H., Li, X., & Kohanbash, G. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2023.104963 · Cited by 97

Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation

Li, H., Luo, Q., Zhang, H., Ma, X., Gu, Z., Gong, Q., & Luo, K. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00437b · Cited by 93

BSA‐AIE Nanoparticles with Boosted ROS Generation for Immunogenic Cell Death Immunotherapy of Multiple Myeloma

Liu, Z., Zhang, J., Liu, H., Shen, H., Meng, N., Qi, X., Ding, K., Song, J., Fu, R., Ding, D., et al. (2022) · Advanced Materials · doi:10.1002/adma.202208692 · Cited by 86

Type I interferons and endoplasmic reticulum stress in health and disease

(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.10.004 · Cited by 83

Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy

Yang, Q., Shi, G., Chen, X., Lin, Y., Cheng, L., Jiang, Q., Yan, X., Jiang, M., Li, Y., Zhang, H., et al. (2020) · Theranostics · doi:10.7150/thno.45391 · Cited by 83

Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot

Li, Z., Zhu, L., Sun, H., Shen, Y., Hu, D., Wu, W., Wang, Y., Qian, C., & Sun, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011297117 · Cited by 80

Bifunctional cancer cell–based vaccine concomitantly drives direct tumor killing and antitumor immunity

Chen, K., Reinshagen, C., van Schaik, T., Rossignoli, F., Borges, P., Mendonca, N. C., Abdi, R., Simon, B. G., Reardon, D. A., Wakimoto, H., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abo4778 · Cited by 81

Nanoparticle-Mediated CD47-SIRPα Blockade and Calreticulin Exposure for Improved Cancer Chemo-Immunotherapy

Luo, J., Liu, R., Chen, F., Zhang, J., Zheng, S.-J., Shao, D., & Du, J. (2023) · ACS Nano · doi:10.1021/acsnano.2c08240 · Cited by 79

Photodynamic Modulation of Endoplasmic Reticulum and Mitochondria Network Boosted Cancer Immunotherapy

Wang, X., Qian, J., Yang, Z., Song, Y., Pan, W., Ye, Y., Qin, X., Yan, X., Huang, X., Wang, X., et al. (2023) · Advanced Materials · doi:10.1002/adma.202310964 · Cited by 80

Enhancing cancer immunotherapy with photodynamic therapy and nanoparticle: making tumor microenvironment hotter to make immunotherapeutic work better

Thiruppathi, J., Vijayan, V., Park, I., Lee, S. E., & Rhee, J. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1375767 · Cited by 85

Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis

Krenzlin, H., Behera, P., Lorenz, V., Passaro, C., Zdioruk, M. I., Nowicki, M. O., Grauwet, K., Zhang, H., Skubal, M., Ito, H., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123375 · Cited by 79

Photodynamic therapy regulates fate of cancer stem cells through reactive oxygen species

Zhang, Z., Wang, K., Mo, J., Xiong, L., & Wen, Y. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i7.562 · Cited by 80

DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing

Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., & Linkermann, A. (2016) · American Journal of Transplantation · doi:10.1111/ajt.14012 · Cited by 81

Large Amino Acid Transporter 1 Selective Liposomes of l -DOPA Functionalized Amphiphile for Combating Glioblastoma

Bhunia, S., Vangala, V., Bhattacharya, D., Ravuri, H. G., Kuncha, M., Chakravarty, S., Sistla, R., & Chaudhuri, A. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00569 · Cited by 77

Current advances in temozolomide encapsulation for the enhancement of glioblastoma treatment

Iturrioz-Rodríguez, N., Samprón, N., & Matheu, A. (2023) · Theranostics · doi:10.7150/thno.82005 · Cited by 86

Tumor‐Activated Size‐Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti‐Tumor Immune Responses

Li, J., Wang, H., Wang, Y., Gong, X., Xu, X., Sha, X., Zhang, A., Zhang, Z., & Li, Y. (2020) · Advanced Materials · doi:10.1002/adma.202002380 · Cited by 72

Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma

Garg, A. D., Vandenberk, L., Woensel, M. V., Belmans, J., Schaaf, M. B. E., Boon, L., Vleeschouwer, S. D., & Agostinis, P. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1295903 · Cited by 73

Immunogenic cell death and its therapeutic or prognostic potential in high-grade glioma

Decraene, B., Yang, Y., Smet, F. D., Garg, A. D., Agostinis, P., & Vleeschouwer, S. D. (2022) · Genes and Immunity · doi:10.1038/s41435-021-00161-5 · Cited by 75

Strategies to Improve the Efficacy of Dendritic Cell-Based Immunotherapy for Melanoma

Hargadon, K. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01594 · Cited by 69

In Situ Attached Photothermal Immunomodulation-Enhanced Nanozyme for the Inhibition of Postoperative Malignant Glioma Recurrence

Nie, D., Ling, Y., Lv, W., Liu, Q., Deng, S., Shi, J., Yang, J., Yang, Y., Ouyang, S., Huang, Y., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03696 · Cited by 65

Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination

Doix, B., Trempolec, N., Riant, O., & Féron, O. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00811 · Cited by 66

Strategies for developing and optimizing cancer vaccines

Maeng, H. M., & Berzofsky, J. A. (2019) · F1000Research · doi:10.12688/f1000research.18693.1 · Cited by 65

Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma

Li, J., Huang, S., Zhou, Z., Lin, W., Chen, S., Chen, M., & Ye, Y. (2018) · Cancer Management and Research · doi:10.2147/cmar.s178326 · Cited by 60

Recent Advances in Oncolytic Virotherapy and Immunotherapy for Glioblastoma: A Glimmer of Hope in the Search for an Effective Therapy?

Stepanenko, A. A., & Chekhonin, V. P. (2018) · Cancers · doi:10.3390/cancers10120492 · Cited by 62

Molecular determinants of immunogenic cell death elicited by radiation therapy

Galassi, C., Klapp, V., Yamazaki, T., & Galluzzi, L. (2023) · Immunological Reviews · doi:10.1111/imr.13271 · Cited by 65

Cancer vaccines: platforms and current progress

Lei, W., Zhou, K., Lei, Y., Qiu, L., & Zhu, H. (2025) · Molecular Biomedicine · doi:10.1186/s43556-024-00241-8 · Cited by 66

Exploiting a new strategy to induce immunogenic cell death to improve dendritic cell-based vaccines for lymphoma immunotherapy

Montico, B., Lapenta, C., Ravo, M., Martorelli, D., Muraro, E., Zeng, B., Comaro, E., Spada, M., Donati, S., Santini, S. M., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1356964 · Cited by 57

Natural compound inducers of immunogenic cell death

Diederich, M. F. (2019) · Trends in Natural Product Research - PSE Young Scientists' Meeting · doi:10.1007/s12272-019-01150-z · Cited by 59

Clinically Relevant Chemotherapeutics Have the Ability to Induce Immunogenic Cell Death in Non-Small Cell Lung Cancer

Flieswasser, T., Loenhout, J. V., Boullosa, L. F., Eynde, A. V. D., Waele, J. D., Audenaerde, J. V. V., Lardon, F., Smits, E., Pauwels, P., & Jacobs, J. (2020) · Cells · doi:10.3390/cells9061474 · Cited by 50

Dual-Sensitive PEG-Sheddable Nanodrug Hierarchically Incorporating PD-L1 Antibody and Zinc Phthalocyanine for Improved Immuno-Photodynamic Therapy

Su, Z., Xiao, Z., Huang, J., Wang, Y., An, Y., Xiao, H. P., Peng, Y., Pang, P., Han, S., Zhu, K., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c20422 · Cited by 57

Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells

Sprooten, J., Vanmeerbeek, I., Datsi, A., Govaerts, J., Naulaerts, S., Laureano, R. S., Borràs, D., Calvet, A., Malviya, V., Kuballa, M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101377 · Cited by 61

Phytochemicals Approach for Developing Cancer Immunotherapeutics

Yin, S.-Y., Yang, N.-S., & Lin, T.-J. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00386 · Cited by 57

The Destruction Of Laser-Induced Phase-Transition Nanoparticles Triggered By Low-Intensity Ultrasound: An Innovative Modality To Enhance The Immunological Treatment Of Ovarian Cancer Cells

Xie, W., Zhu, S., Yang, B., Chen, C., Chen, S., Liu, Y., Nie, X., Hao, L., Wang, Z., Sun, J., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s208404 · Cited by 56

Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer

Szymańska, E., Nowak, P., Kolmus, K., Cybulska, M., Goryca, K., Derezińska‐Wołek, E., Szumera‐Ciećkiewicz, A., Brewińska‐Olchowik, M., Grochowska, A., Piwocka, K., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201910812 · Cited by 56

Clinical implication of cellular vaccine in glioma: current advances and future prospects

Yan, Y., Zeng, S., Gong, Z., & Xu, Z. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01778-6 · Cited by 56

Mitochondria-Targeting Immunogenic Cell Death Inducer Improves the Adoptive T-Cell Therapy Against Solid Tumor

Jiang, Q., Zhang, C., Wang, H., Peng, T., Li, Z., Wang, Y., Han, W., & Shi, C. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01196 · Cited by 55

Hypericin: A natural anthraquinone as promising therapeutic agent

Wu, J., Zhang, J., Xia, C., Ding, K., Li, X., Pan, X.-G., Xu, J., He, J., & Zhang, W. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154654 · Cited by 57

Next-generation immunogenic dendritic cell vaccines achieve a danger signaling and T cell-driven eradication of high-grade glioma

Garg, A., Vandenberk, L., Koks, C., Verschuere, T., Gool, S. V., & Agostinis, P. (2016) · Klinische Pädiatrie · doi:10.1055/s-0036-1593558

Irradiation of necrotic tumor cells used to pulse dendritic cells (DCs) potentiates DC vaccine-induced anti-tumor immunity in a mouse model of high-grade glioma

Vandenberk, L., Garg, A. D., Agostinis, P., Verschuere, T., Koks, C., Vleeschouwer, S. D., & Gool, S. V. (2014) · Journal for ImmunoTherapy of Cancer · doi:10.1186/2051-1426-2-s3-p163 · Cited by 1

Targeting immunogenic cell death for glioma immunotherapy

Mishchenko, T. A., Turubanova, V. D., Gorshkova, E. N., Krysko, O., Vedunova, M. V., & Krysko, D. V. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.10.005 · Cited by 15

Immunogene op oxidatietherapie-gebaseerde tweede generatie dendritische celvaccins voor de behandeling van hooggradige gliomen

Vandenberk, L. (2016) · Lirias

Approaches to Improve Efficiency of Dendritic Cell-based Therapy of High Grade Gliomas

Chistiakov, D. A., Chekhonin, I. V., Gurina, O. I., Bobryshev, Y. V., & Chekhonin, V. P. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160719110618 · Cited by 7