Cited by 466Glioma Diagnosis and TreatmentCancer Genomics and DiagnosticsGene expression and cancer classification

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Origin of the U87MG glioma cell line: Good news and bad news

Allen, Marie, Bjerke, Mia, Edlund, Hanna, Nelander, Sven, Westermark, Bengt·2016·Science Translational Medicine

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Abstract

The DNA profile of the publicly available and widely used glioma cell line U87MG is quite different from that of the original cell line.

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Crossref · 10.1126/scitranslmed.aaf6853

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Authors: Allen, M., Bjerke, M., Edlund, H., Nelander, S., & Westermark, B.
Affiliations: Uppsala University (SE)
Corresponding author: Westermark, Bengt
ORCID: Allen, Marie
Edlund, Hanna
Nelander, Sven
Westermark, Bengt
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2016-08-31
Volume: 8
Issue: 354
Pages: 354re3-354re3
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aaf6853
OpenAlex: W2509121458
Cited by: 466
References: 15
Citations by year: 2026: 28 · 2025: 33 · 2024: 43 · 2023: 36 · 2022: 49 · 2021: 41 · 2020: 59 · 2019: 51 · 2018: 84 · 2017: 37 · 2016: 5
FWCI: 42.81
Type: journal article
Language: en
Open access: closed
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science Translational Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Swedish Cancer Society
Swedish Crime Victim Compensation and Support Authority
Topics: Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene expression and cancer classification
Keywords: glioma cell lines, glioblastoma, tumor origin, genetic profiling, gene expression profiling, cell line misidentification, translational oncology
MeSH terms: Brain Neoplasms, DNA, Mitochondrial, DNA, Neoplasm, Glioblastoma, Glioma, Humans, DNA Fingerprinting, Microsatellite Repeats, Cell Culture Techniques, Gene Expression Profiling, Cell Line, Tumor, Translational Research, Biomedical

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Origin of the U87MG glioma cell line: Good news and bad news

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