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Improved tissue cryopreservation using inductive heating of magnetic nanoparticles
Abstract
A scalable technology using iron oxide nanoparticles and inductive radiofrequency heating rapidly and uniformly rewarms vitrified tissues.
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No extra white space was seen within the extravascular space of nanowarmed kidneys, which would have been seen if ice had formed during the process.
“No extra “white space” was seen within the extravascular space of the nanowarmed kidneys, which would have been seen if ice had formed during the process14.”
From Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model (2023) · cites this paper as [14]
Modeled and experimentally measured magnetic field distributions were used to compare spatial uniformity between the 15 kW and 120 kW RF coils.
“We used modeled as well as experimentally measured magnetic field distribution to compare spatial uniformity between the previously characterized 15 kW6 and the new 120 kW RF coils (Fig. S16).”
From Physical vitrification and nanowarming at liter-scale CPA volumes: toward organ cryopreservation (2025) · cites this paper as [6]
Nanowarming generates heat from within and throughout the organ rather than just at its surface.
“we have developed “nanowarming,” which achieves both objectives simultaneously by generating heat from within and throughout the organ rather than just at its surface14.”
From Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model (2023) · cites this paper as [14]
Nanowarming rates are not dependent on system size or boundary conditions because the RF frequencies used penetrate tissues without attenuation.
“Notably, nanowarming rates are not dependent on system size or boundary conditions since the RF frequencies used penetrate tissues without attenuation14–16.”
From Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model (2023) · cites this paper as [14]
Even under conditions where vitrification upon cooling was successful, even faster rates are required upon rewarming, leading to failures at the rabbit kidney scale.
“Even under conditions where vitrification upon cooling was successful, even faster rates are required upon rewarming, leading to failures (ice formation and/or cracking) at the rabbit kidney scale6.”
From Physical vitrification and nanowarming at liter-scale CPA volumes: toward organ cryopreservation (2025) · cites this paper as [6]
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Research works printed but not linked: 31
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- J. Zhang, H. L. Ring, K. R. Hurley, Q. Shao, C. S. Carlson, D. Idiyatullin, N. Manuchehrabadi, P. J. Hoopes, C. L. Haynes, J. C. Bischof, M. Garwood, Quantification and biodistribution of iron oxide nanoparticles in the primary clearance organs of mice using T1 contrast for heating. Magn. Reson. Med. 25, 10.1002/mrm.26394 (2016). · DOI
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Cited by
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Han, Z., Rao, J. S., Gangwar, L., Namsrai, B.-E., Pasek-Allen, J. L., Etheridge, M. L., Wolf, S. M., Pruett, T. L., Bischof, J. C., & Finger, E. B. (2023) · Nature Communications · doi:10.1038/s41467-023-38824-8 · Cited by 173
Self-citationCao, Y., Hassan, M., Cheng, Y., Chen, Z., Wang, M., Zhang, X., Haider, Z., & Zhao, G. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b02887 · Cited by 54
Scalable Production and Cryostorage of Organoids Using Core–Shell Decoupled Hydrogel Capsules
Lu, Y., Fu, D., An, D., Chiu, A., Schwartz, R., Nikitin, A. Y., & Ma, M. (2017) · Advanced Biosystems · doi:10.1002/adbi.201700165 · Cited by 51
Messner, F., Guo, Y., Etra, J. W., & Brandacher, G. (2019) · Transplant International · doi:10.1111/tri.13432 · Cited by 29
Physical vitrification and nanowarming at liter-scale CPA volumes: toward organ cryopreservation
Gangwar, L., Han, Z., Scheithauer, C., Namsrai, B.-E., Kantesaria, S., Goldstein, R., Etheridge, M. L., Finger, E. B., & Bischof, J. C. (2025) · Nature Communications · doi:10.1038/s41467-025-63483-2 · Cited by 26
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Metadata
- Authors
- Manuchehrabadi, N., Gao, Z., Zhang, J., Ring, H. L., Shao, Q., Liu, F., McDermott, M., Fok, A., Rabin, Y., Brockbank, K. G. M., Garwood, M., Haynes, C. L., & Bischof, J. C.
- Affiliations
- Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
- Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA.
- Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
- Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, Minneapolis, MN 55455, USA.
- Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
- Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
- Venue
- Science Translational Medicine
- Published
- 2017-03
- Volume
- 9
- Issue
- 379
- ISSN
- 1946-6234
- 1946-6242
- PMC
- PMC5470364
- Cited by
- 305
- References
- 0
- Language
- en
- Funders
- NIH Office of the Director (award279901, P41EB015894,R43HL123317)
- NSF Office of the Director (award279902, 1336659)
- Medical Research and Materiel Command, U.S. Army Medical Department (award279903, W81XWH-15-C-0173)
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