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Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
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Commensal skin bacteria produce previously unknown antimicrobial peptides that can inhibit Staphylococcus aureus colonization of atopic dermatitis subjects.
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“cutaneous commensals such as coagulase-negative Staphylococcus strains produce antimicrobials that protect from pathobionts such as Staphylococcus aureus.211”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [211]
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Metadata
- Authors
- Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., Latif, H., Kim, J.-N., Lockhart, A., Artis, K., David, G., Taylor, P., Streib, J., Dorrestein, P. C., Grier, A., Gill, S. R., Zengler, K., Hata, T. R., Leung, D. Y. M., & Gallo, R. L.
- Affiliations
- University of California San Diego (US)
- Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
- Rho (United States) (US)
- National Jewish Health (US)
- University of Rochester (US)
- Corresponding author
- Gallo, Richard L.
- ORCID
- Nakatsuji, Teruaki
- Chen, Tiffany H.
- Narala, Saisindhu
- Yun, Tong
- Shafiq, Faiza
- Kotol, Paul F.
- Bouslimani, Amina
- Melnik, Alexey V.
- Latif, Haythem
- Lockhart, Alexandre
- Artis, Keli
- David, Gloria
- Taylor, Patricia
- Streib, Joanne
- Dorrestein, Pieter C.
- Grier, Alex
- Gill, Steven R.
- Zengler, Karsten
- Hata, Tissa R.
- Leung, Donald Y. M.
- Gallo, Richard L.
- Venue
- Science Translational Medicine
- Published
- 2017-02-22
- Volume
- 9
- Issue
- 378
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5600545
- OpenAlex
- W2590317180
- Cited by
- 1,095
- References
- 67
- Citations by year
- 2026: 94 · 2025: 136 · 2024: 141 · 2023: 122 · 2022: 118 · 2021: 129 · 2020: 115 · 2019: 116 · 2018: 86 · 2017: 38
- FWCI
- 110.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (award290992)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- antimicrobial agents, Staphylococcus aureus, atopic dermatitis, skin microbiome, dysbiosis, host-pathogen interaction, skin barrier protection
- MeSH terms
- Amino Acid Sequence, Animals, Anti-Infective Agents, Bacteria, Coagulase, Dermatitis, Atopic, Humans, Skin, Staphylococcus aureus, Colony Count, Microbial, Antimicrobial Cationic Peptides, Sus scrofa, Mice, Microbiota, Dysbiosis
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