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Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
Open accessAbstract
Commensal skin bacteria produce previously unknown antimicrobial peptides that can inhibit Staphylococcus aureus colonization of atopic dermatitis subjects.
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“cutaneous commensals such as coagulase-negative Staphylococcus strains produce antimicrobials that protect from pathobionts such as Staphylococcus aureus.211”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [211]
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Metadata
- Authors
- Nakatsuji, T., Chen, T. H., Narala, S., Chun, K. A., Two, A. M., Yun, T., Shafiq, F., Kotol, P. F., Bouslimani, A., Melnik, A. V., Latif, H., Kim, J.-N., Lockhart, A., Artis, K., David, G., Taylor, P., Streib, J., Dorrestein, P. C., Grier, A., Gill, S. R., Zengler, K., Hata, T. R., Leung, D. Y. M., & Gallo, R. L.
- Affiliations
- University of California San Diego (US)
- Department of Dermatology, University of California, San Diego, La Jolla, CA 92092, USA.
- Rho (United States) (US)
- National Jewish Health (US)
- University of Rochester (US)
- Corresponding author
- Gallo, Richard L.
- ORCID
- Nakatsuji, Teruaki
- Chen, Tiffany H.
- Narala, Saisindhu
- Yun, Tong
- Shafiq, Faiza
- Kotol, Paul F.
- Bouslimani, Amina
- Melnik, Alexey V.
- Latif, Haythem
- Lockhart, Alexandre
- Artis, Keli
- David, Gloria
- Taylor, Patricia
- Streib, Joanne
- Dorrestein, Pieter C.
- Grier, Alex
- Gill, Steven R.
- Zengler, Karsten
- Hata, Tissa R.
- Leung, Donald Y. M.
- Gallo, Richard L.
- Venue
- Science Translational Medicine
- Published
- 2017-02-22
- Volume
- 9
- Issue
- 378
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5600545
- OpenAlex
- W2590317180
- Cited by
- 1,095
- References
- 67
- Citations by year
- 2026: 94 · 2025: 136 · 2024: 141 · 2023: 122 · 2022: 118 · 2021: 129 · 2020: 115 · 2019: 116 · 2018: 86 · 2017: 38
- FWCI
- 110.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (award290992)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- antimicrobial agents, Staphylococcus aureus, atopic dermatitis, skin microbiome, dysbiosis, host-pathogen interaction, skin barrier protection
- MeSH terms
- Amino Acid Sequence, Animals, Anti-Infective Agents, Bacteria, Coagulase, Dermatitis, Atopic, Humans, Skin, Staphylococcus aureus, Colony Count, Microbial, Antimicrobial Cationic Peptides, Sus scrofa, Mice, Microbiota, Dysbiosis
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