Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome
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Brief, early treatments with lovastatin provide long-lasting rescue of associative memory deficits in a rat model of Fragile X.
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Early brief treatment with lovastatin prevented associative learning deficits in Fmr1 KO rats.
“Early brief treatment with lovastatin also prevented associative learning deficits in Fmr1 KO rats15, but cholesterol was not measured in relation to lovastatin treatment responses in the rodent FXS models.”
From An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis (2023) · cites this paper as [15]
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Fitting Linear Mixed-Effects Models Using <b>lme4</b>
Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015) · Journal of Statistical Software · doi:10.18637/jss.v067.i01 · Cited by 86,835 · see citing works
Animal research: Reporting <i>in vivo</i> experiments: The ARRIVE guidelines
Kilkenny, C., Browne, W., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00872.x · Cited by 3,625 · see citing works
Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90397-h · Cited by 3,481 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580 · see citing works
Self-citationRecognition memory: What are the roles of the perirhinal cortex and hippocampus?
Brown, M. W., & Aggleton, J. P. (2001) · Nature reviews. Neuroscience · doi:10.1038/35049064 · Cited by 1,555 · see citing works
Correction of Fragile X Syndrome in Mice
Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979 · see citing works
Self-citationHagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838 · see citing works
Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
Geurts, A. M., Cost, G. J., Freyvert, Y., Zeitler, B., Miller, J. C., Choi, V. M., Jenkins, S. S., Wood, A., Cui, X., Meng, X., et al. (2009) · Science · doi:10.1126/science.1172447 · Cited by 817 · see citing works
Critical periods in speech perception: New directions
Werker, J. F., & Hensch, T. K. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015104 · Cited by 774 · see citing works
A point mutation in the FMR-1 gene associated with fragile X mental retardation
Boulle, K. D., Verkerk, A. J. M. H., Reyniers, E., Vits, L., Hendrickx, J., Roy, B. V., Bos, F. V. D., de Graaff, E., Oostra, B. A., & Willems, P. J. (1993) · Nature Genetics · doi:10.1038/ng0193-31 · Cited by 624 · see citing works
Dix, S. L., & Aggleton, J. P. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00079-5 · Cited by 598 · see citing works
Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice
Michalon, A., Sidorov, M., Ballard, T. M., Ozmen, L., Spooren, W., Wettstein, J. G., Jaeschke, G., Bear, M. F., & Lindemann, L. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.009 · Cited by 489 · see citing works
Self-citationAltered Neuronal and Circuit Excitability in Fragile X Syndrome
Contractor, A., Klyachko, V. A., & Portera‐Cailliau, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.017 · Cited by 425 · see citing works
Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3888-10.2010 · Cited by 384 · see citing works
Self-citationIntegrated Memory for Object, Place, and Context in Rats: A Possible Model of Episodic-Like Memory?
Eacott, M. J., & Norman, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2975-03.2004 · Cited by 344 · see citing works
Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome
Berry-Kravis, E. M., Lindemann, L., Jønch, A. E., Apostol, G., Bear, M. F., Carpenter, R. L., Crawley, J. N., Curie, A., Des Portes, V., Hossain, F., et al. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.221 · Cited by 336 · see citing works
Self-citationAutism spectrum disorder in fragile X syndrome: cooccurring conditions and current treatment
Kaufmann, W. E., Kidd, S. A., Andrews, H. F., Budimirovic, D. B., Esler, A., Haas-Givler, B., Stackhouse, T., Riley, C., Peacock, G., Sherman, S. L., et al. (2017) · PEDIATRICS · doi:10.1542/peds.2016-1159f · Cited by 268 · see citing works
Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice
Harlow, E. G., Till, S. M., Russell, T. A., Wijetunge, L. S., Kind, P., & Contractor, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.024 · Cited by 252 · see citing works
Self-citationHenderson, C., Wijetunge, L., Kinoshita, M. N., Shumway, M., Hammond, R. S., Postma, F. R., Brynczka, C., Rush, R., Thomas, A., Paylor, R., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004218 · Cited by 249 · see citing works
Self-citationFragile X mental retardation protein and synaptic plasticity
Sidorov, M. S., Auerbach, B. D., & Bear, M. F. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-15 · Cited by 243 · see citing works
Self-citationLangston, R. F., & Wood, E. R. (2009) · Hippocampus · doi:10.1002/hipo.20714 · Cited by 240 · see citing works
Self-citationMeredith, R. M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.12.001 · Cited by 237 · see citing works
Lateral entorhinal cortex is critical for novel object‐context recognition
Wilson, D. I. G., Langston, R. F., Schlesiger, M. I., Wagner, M. A., Watanabe, S., & Ainge, J. A. (2013) · Hippocampus · doi:10.1002/hipo.22095 · Cited by 232 · see citing works
Osterweil, E. K., Chuang, S.-C., Chubykin, A. A., Sidorov, M., Bianchi, R., Wong, R. K. S., & Bear, M. F. (2013) · Neuron · doi:10.1016/j.neuron.2012.01.034 · Cited by 230 · see citing works
Self-citationThe Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice
He, Q., Nomura, T., Xu, J., & Contractor, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4447-13.2014 · Cited by 230 · see citing works
Norman, G., & Eacott, M. J. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.2.557 · Cited by 217 · see citing works
Arbaclofen in fragile X syndrome: results of phase 3 trials
Berry-Kravis, E., Hagerman, R., Visootsak, J., Budimirovic, D., Kaufmann, W. E., Cherubini, M., Zarevics, P., Walton-Bowen, K., Wang, P., Bear, M. F., et al. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9181-6 · Cited by 183 · see citing works
Self-citationTreatment of Familial Hypercholesterolemia in Children and Adolescents: Effect of Lovastatin
Lambert, M. A., Lupien, P.-J., Gagné, C., Levy, E. H., Blaichman, S., Langlois, S., Hayden, M. R., Rose, V., Clarke, J. T. R., Wolfe, B. M. J., et al. (1996) · PEDIATRICS · doi:10.1542/peds.97.5.619 · Cited by 158 · see citing works
The Role of Activity in Development of the Visual System
Sengpiel, F., & Kind, P. C. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01318-0 · Cited by 149 · see citing works
Self-citationA mouse model of the human Fragile X syndrome I304N mutation
Zang, J. B., Nosyreva, E. D., Spencer, C. M., Volk, L. J., Musunuru, K., Zhong, R., Stone, E. F., Yuva-Paylor, L. A., Huber, K. M., Paylor, R., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000758 · Cited by 138 · see citing works
Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory
Wilson, D. I. G., Watanabe, S., Milner, H., & Ainge, J. A. (2013) · Hippocampus · doi:10.1002/hipo.22165 · Cited by 137 · see citing works
Ontogeny of neural circuits underlying spatial memory in the rat
Ainge, J. A., & Langston, R. F. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00008 · Cited by 114 · see citing works
Chao, O. Y.-H., Huston, J. P., Li, J., Wang, A., & Silva, M. A. D. S. (2015) · Hippocampus · doi:10.1002/hipo.22547 · Cited by 110 · see citing works
Till, S. M., Asiminas, A., Jackson, A. D., Katsanevaki, D., Barnes, S. A., Osterweil, E. K., Bear, M. F., Chattarji, S., Wood, E. R., Wyllie, D. J. A., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv299 · Cited by 109 · see citing works
Self-citationCell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome
Thomson, S. R., Seo, S. S., Barnes, S. A., Louros, S. R., Muscas, M., Dando, O., Kirby, C., Wyllie, D. J. A., Hardingham, G. E., Kind, P. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.013 · Cited by 100 · see citing works
Self-citationAltered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome
Till, S. M., Wijetunge, L. S., Seidel, V. G., Harlow, E., Wright, A. K., Bagni, C., Contractor, A., Gillingwater, T. H., & Kind, P. C. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds030 · Cited by 91 · see citing works
Self-citationLai, J., Sobala-Drozdowski, M., Zhou, L., Doering, L. C., Faure, P. A., & Foster, J. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.10.049 · Cited by 84 · see citing works
Barnes, S. A., Wijetunge, L. S., Jackson, A. D., Katsanevaki, D., Osterweil, E. K., Komiyama, N. H., Grant, S. G. N., Bear, M. F., Nägerl, U. V., Kind, P. C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1087-15.2015 · Cited by 84 · see citing works
Self-citationHippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
Bostrom, C. A., Yau, S., Majaess, N. M., Vetrici, M. A., Gil‐Mohapel, J., & Christie, B. R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.033 · Cited by 79 · see citing works
Effect of lovastatin on behavior in children and adults with fragile X syndrome: An open‐label study
Çaku, A., Pellerin, D., Bouvier, P., Riou, E., & Corbin, F. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36750 · Cited by 77 · see citing works
Martin, H. G. S., Lassalle, O., Brown, J. T., & Manzoni, O. J. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv031 · Cited by 60 · see citing works
Fragile X syndrome: From targets to treatments
Wijetunge, L. S., Chattarji, S., Wyllie, D. J. A., & Kind, P. C. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.028 · Cited by 49 · see citing works
Self-citationOntogeny of object versus location recognition in the rat: Acquisition and retention effects
Westbrook, S. R., Brennan, L. E., & Stanton, M. E. (2014) · Developmental Psychobiology · doi:10.1002/dev.21232 · Cited by 48 · see citing works
Yun, S., Platholi, J., Flaherty, M. S., Fu, W., Kottmann, A. H., & Tóth, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.086 · Cited by 44 · see citing works
Repurposing available drugs for neurodevelopmental disorders: The fragile X experience
Tranfaglia, M. R., Thibodeaux, C., Mason, D. J., Brown, D., Roberts, I., Smith, R. J., Guilliams, T., & Cogram, P. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.05.004 · Cited by 39 · see citing works
Ontogeny of object-in-context recognition in the rat
Ramsaran, A. I., Westbrook, S. R., & Stanton, M. E. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.011 · Cited by 33 · see citing works
Determinants of object‐in‐context and object‐place‐context recognition in the developing rat
Ramsaran, A. I., Sanders, H. R., & Stanton, M. E. (2016) · Developmental Psychobiology · doi:10.1002/dev.21432 · Cited by 24 · see citing works
Developmental trajectories of executive functions in young males with fragile X syndrome
Hooper, S. R., Hatton, D. D., Sideris, J. H., Sullivan, K. M., Ornstein, P. A., & Bailey, D. B. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2018.05.014 · Cited by 22 · see citing works
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“This pathway is targeted in FXS preclinical studies (5-7) and clinical trials (8-10) by administering”
BackgroundAstrocytes in fragile X syndrome
Talvio, K., & Castrén, M. L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1322541 · Cited by 8 · see citing works
- Authors
- Asiminas, A., Jackson, A. D., Louros, S. R., Till, S. M., Spano, T., Dando, O., Bear, M. F., Chattarji, S., Hardingham, G. E., Osterweil, E. K., Wyllie, D. J. A., Wood, E. R., & Kind, P. C.
- Affiliations
- Simons Initiative for the Developing Brain (GB)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.
- UK Dementia Research Institute (GB)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Asiminas, Antonis
- Jackson, Adam D.
- Louros, Susana R.
- Till, Sally M.
- Osterweil, Emily K.
- Wyllie, David J. A.
- Wood, Emma R.
- Kind, Peter C.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-05-29
- Volume
- 11
- Issue
- 494
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8162683
- OpenAlex
- W2947070139
- Cited by
- 78
- References
- 50
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 15 · 2023: 7 · 2022: 13 · 2021: 10 · 2020: 18 · 2019: 3 · 2018: 1
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- FRAXA Research Foundation
- Medical Research Council
- RS MacDonald Charitable Trust
- Greek State Scholarship Foundation
- SFARI
- Patrick Wild Centre
- The Shirley Foundation
- Wadhwani Foundation
- Indian Department of Biotechnology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
- Keywords
- fragile X syndrome, lovastatin, associative learning, associative memory, synaptic plasticity, protein synthesis, neurodevelopmental disorders, cognitive development
- MeSH terms
- Animals, Disease Models, Animal, Exploratory Behavior, Fragile X Syndrome, Hippocampus, Learning, Lovastatin, Male, Memory, Neuronal Plasticity, Task Performance and Analysis, Prefrontal Cortex, Recognition, Psychology, Mice, Rats, Fragile X Messenger Ribonucleoprotein 1
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