Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
Abstract
Targeted gene disruption in rats paves the way for new human disease models.
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Some countries discouraged or prohibited germline modification research a decade before the technical feasibility of germline modification was confirmed in rats in 2009.
“Because of such concerns - as well as for serious ethical reasons - some countries discouraged or prohibited this type of research a decade before the technical feasibility of germline modification was confirmed in rats in 2009 (ref. 9).”
From Don’t edit the human germ line (2015) · cites this paper as [9]
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Cites
Progress and prospects in rat genetics: a community view
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Research works printed but not linked: 5
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- Authors
- Geurts, A. M., Cost, G. J., Freyvert, Y., Zeitler, B., Miller, J. C., Choi, V. M., Jenkins, S. S., Wood, A., Cui, X., Meng, X., Vincent, A., Lam, S., Michalkiewicz, M., Schilling, R., Foeckler, J., Kalloway, S., Weiler, H., Ménoret, S., Anegon, I., Davis, G. D., Zhang, L., Rebar, E. J., Gregory, P. D., Urnov, F. D., Jacob, H. J., & Buelow, R.
- Venue
- Science
- Published
- 2009-07-24
- Volume
- 325
- Issue
- 5939
- Pages
- 433-433
- ISSN
- 0036-8075
- 1095-9203
- PMC
- PMC2831805
- Cited by
- 817
- References
- 1
- Language
- en
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