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Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
Open accessPublished version of a preprint
Abstract
Host and parasite RNA sequencing is combined with parasite load estimates to reveal mechanisms associated with human severe malaria.
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“Moreover, RNA-seq analyses of the human host can be used to identify novel or underappreciated host–microbial interactions directly from clinical samples, as previously shown for patients with Lyme disease68, dengue80 or malaria81.”
From Clinical metagenomics (2019) · cites this paper as [81]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
WGCNA: an R package for weighted correlation network analysis
Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658
REVIGO summarizes and visualizes long lists of gene ontology terms
Supek, F., Bošnjak, M., Škunca, N., & Šmuc, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021800 · Cited by 6,264
GENCODE: The reference human genome annotation for The ENCODE Project
Harrow, J., Frankish, A., Gonzalez, J. M., Tapanari, E., Diekhans, M., Kokocinski, F., Aken, B. L., Barrell, D., Zadissa, A., Searle, S., et al. (2012) · Genome Research · doi:10.1101/gr.135350.111 · Cited by 4,585
The immunopathology of sepsis and potential therapeutic targets
van der Poll, T., van de Veerdonk, F. L., Scicluna, B. P., & Netea, M. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.36 · Cited by 1,957
Neutrophil Function: From Mechanisms to Disease
Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D., & Zychlinsky, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074942 · Cited by 1,782
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Gonzalez, K. J., Giraldo, D. M., & Gutiérrez, J. B. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/804716 · Cited by 1
Three hallmarks of malaria-induced selection in human genomesPreprint
Tennessen, J. A., & Duraisingh, M. T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.07.170092 · Cited by 1
Mukherjee, P., Burgio, G., & Heitlinger, E. G. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/576116 · Cited by 1
Andradi-Brown, C., Wichers-Misterek, J. S., von Thien, H., Höppner, Y. D., Scholz, J. A. M., Hansson, H. S., Hocke, E. F., Gilberger, T., Duffy, M. F., Lavstsen, T., et al. (2023) · eLife · doi:10.7554/elife.87726.1 · Cited by 1
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Jia, H., Liu, X., Wang, Z., Zhang, W., & Chen, X. (2023) · Research Square · doi:10.21203/rs.3.rs-3097514/v1 · Cited by 1
Anemia and tissue hypoxia are major determinants of malarial hypelactatemiaPreprint
Georgiadou, A., Yoon, C. E., Yu, H., Pearson, W. H., Ueno, A., Ebmeier, S., Larrouy-Maumus, G. J., & Cunnington, A. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.22.619641 · Cited by 1
Self-citationInnate immune responses to Plasmodium falciparum disrupt the blood-brain barrierPreprint
Batzilla, A., Dernick, P., Bezney, J., Gschwind, A. R., Nakaki, F., Altadill, M., Fleckenstein, H., Piatti, L., Sanz, S., Fiegl, M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683440 · Cited by 1
Genome-wide expression in neonatal encephalopathy
Montaldo, P. (2018) · Spiral (Imperial College London) · doi:10.25560/78568
Hocking, S. E., Stewart, L. B., Tarr, S. J., Fréville, A., Tetteh, K. K. A., Ahouidi, A. D., Amambua‐Ngwa, A., Diakité, M., Awandare, G. A., & Conway, D. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.18.481051
Self-citationRNAseq of Infected Erythrocyte Surface Antigen-Encoding Genes
Nguyen, H. H. T., Azizan, S., Yeoh, L. M., Tang, J., & Duffy, M. F. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2189-9_15
Thomson-Luque, R., Votborg-Novél, L., Osório, N. S., & Portugal, S. (2022) · Nature Communications · doi:10.1038/s41467-022-32998-3
Gene expression of macaques infected with malaria species of zoonotic concernPreprint
Trujillo, A. E., & Bergey, C. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.19.524806
Andradi-Brown, C., Wichers-Misterek, J. S., von Thien, H., Höppner, Y. D., Scholz, J. A. M., Hansson, H. S., Hocke, E. F., Gilberger, T., Duffy, M. F., Lavstsen, T., et al. (2023) · eLife · doi:10.7554/elife.87726.1.sa4
Self-citationInteractions shaping the interactome
Swaminathan, A., Ravi, V., Gupta, R., Singh, S., Goswami, S., Mishra, P., Pandey, R., & Shamim, U. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18769-8.00001-5
Neutrophils cultured ex vivo from CD34 + stem cells are immature and genetically tractablePreprint
Naveh, C. A., Roberts, K., Rice, C. M., Fleming, K., Thompson, M., Panyapiean, N., Diezmann, S., Moura, P. L., Toye, A. M., & Amulic, B. (2023) · medRxiv · doi:10.1101/2023.07.12.23292345
Gene expression analyses reveal differences in children’s response to malaria according to their agePreprint
Tebben, K., Yirampo, S., Coulibaly, D. M., Kone, A. K., Laurens, M. B., Stucke, E. M., Dembélé, A., Tolo, Y., Traoré, K., Niangaly, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.24.563751
Gene expression analyses reveal differences in children’s response to malaria according to their agePreprint
Tebben, K., Yirampo, S., Coulibaly, D. M., Kone, A. K., Laurens, M. B., Stucke, E. M., Dembélé, A., Tolo, Y., Traoré, K., Niangaly, A., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3487114/v1
Zhang, Y., Su, X., Li, J., Shi, J., & Xie, L. (2022) · Figshare · doi:10.6084/m9.figshare.21563882
Kucharski, M., Tripathi, J., Nayak, S., Zhu, L., Wirjanata, G., van der Pluijm, R. W., Dhorda, M., Dondorp, A. M., & Bozdech, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14433542
Zhang, Y., Su, X., Li, J., Shi, J., & Xie, L. (2022) · Figshare · doi:10.6084/m9.figshare.21563876
Zhang, Y., Su, X., Li, J., Shi, J., & Xie, L. (2022) · Figshare · doi:10.6084/m9.figshare.21563879
The Host Response to Infections: The “-omics” Revolution
Mejías, A., & Ramilo, O. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-82763-8.00003-0
Mejías, A., & Ramilo, O. (2025) · Wiley eBooks · doi:10.1002/9781683674597.ch8
Prah, D. A., Amoah, L. E., Gibbins, M. P., Bediako, Y., Cunnington, A. J., Awandare, G. A., & Hafalla, J. C. R. (2020) · Figshare · doi:10.6084/m9.figshare.13076444
Self-citationNaveh, C. A., Roberts, K., Zakrzewski, P., Rice, C. M., Ponce-Garcia, F. M., Fleming, K., Thompson, M., Panyapiean, N., Jiang, H., Diezmann, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728399
Kucharski, M., Tripathi, J., Nayak, S., Zhu, L., Wirjanata, G., van der Pluijm, R. W., Dhorda, M., Dondorp, A. M., & Bozdech, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14433539
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563906
Naveh, C. A., Roberts, K., Zakrzewski, P., Rice, C. M., Ponce-Garcia, F. M., Fleming, K., Thompson, M., Panyapiean, N., Jiang, H., Diezmann, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728402
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563897
Prah, D. A., Amoah, L. E., Gibbins, M. P., Bediako, Y., Cunnington, A. J., Awandare, G. A., & Hafalla, J. C. R. (2020) · Figshare · doi:10.6084/m9.figshare.13076447
Self-citationKucharski, M., Tripathi, J., Nayak, S., Zhu, L., Wirjanata, G., van der Pluijm, R. W., Dhorda, M., Dondorp, A. M., & Bozdech, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14433536
Prah, D. A., Amoah, L. E., Gibbins, M. P., Bediako, Y., Cunnington, A. J., Awandare, G. A., & Hafalla, J. C. R. (2020) · Figshare · doi:10.6084/m9.figshare.13076450
Self-citationPrah, D. A., Amoah, L. E., Gibbins, M. P., Bediako, Y., Cunnington, A. J., Awandare, G. A., & Hafalla, J. C. R. (2020) · Figshare · doi:10.6084/m9.figshare.13076441
Self-citationZhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563903
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563909
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563894
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563885
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563891
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563888
Zhang, Y.-H., Su, X.-Z., Li, J., Shi, J.-J., & Xie, L.-H. (2022) · Figshare · doi:10.6084/m9.figshare.21563900
Sistermans, T., Libbrecht, R., & Foitzik, S. (2026) · BMC Genomics · doi:10.1186/s12864-026-12581-6
The Enzymatic Mechanism of OAS: How Metal Ions and Quantum Effects Help Activate Innate Immunity
Kats, P., Zhou, X., Wiebe, J., Zeymer, O., Baruch, P., Taft, M. H., Reinke, P. Y. A., Günther, S., Meents, A., Hartmann, R., et al. (2026) · ACS Omega · doi:10.1021/acsomega.5c13236
Metadata
- Authors
- Lee, H. J., Georgiadou, A., Walther, M., Nwakanma, D., Stewart, L. B., Levin, M., Otto, T. D., Conway, D. J., Coin, L. J., & Cunnington, A. J.
- Affiliations
- The University of Queensland (AU)
- London School of Hygiene & Tropical Medicine (GB)
- MRC Unit the Gambia (GM)
- Imperial College London (GB)
- Wellcome Sanger Institute (GB)
- Corresponding author
- Cunnington, Aubrey J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-06-27
- Volume
- 10
- Issue
- 447
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6326353
- OpenAlex
- W2766874071
- Cited by
- 141
- References
- 105
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 24 · 2021: 14 · 2020: 23 · 2019: 19 · 2018: 5
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Wellcome Trust (098051)
- Medical Research Council (MR/L006529/1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- severe malaria, Plasmodium falciparum, host-pathogen interaction, transcriptome, pathogen load, translation genes, granulopoiesis, interferon-gamma, type I interferon signaling, disease severity, gene co-regulation
- MeSH terms
- Child, Child, Preschool, Female, Gene Expression Regulation, Humans, Male, Neutrophils, Plasmodium falciparum, Species Specificity, Malaria, Falciparum, Sequence Analysis, RNA, Parasitemia, Gene Expression Profiling, Gene Regulatory Networks, Host-Pathogen Interactions
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