The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria
Open accessPublished version of a preprint
Abstract
Host and parasite RNA sequencing is combined with parasite load estimates to reveal mechanisms associated with human severe malaria.
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“Moreover, RNA-seq analyses of the human host can be used to identify novel or underappreciated host–microbial interactions directly from clinical samples, as previously shown for patients with Lyme disease68, dengue80 or malaria81.”
From Clinical metagenomics (2019) · cites this paper as [81]
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Cites
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Chiu, C. Y., & Miller, S. A. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-019-0113-7 · Cited by 1,620
The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle
Howick, V. M., Russell, A. J. C., Andrews, T. S., Heaton, H., Reid, A. J., Natarajan, K. N., Butungi, H., Metcalf, T., Verzier, L. H., Rayner, J. C., et al. (2019) · Science · doi:10.1126/science.aaw2619 · Cited by 318
New insights into malaria pathogenesis
Moxon, C. A., Gibbins, M. P., McGuinness, D., Milner, D. A., & Marti, M. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032640 · Cited by 207
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
Knackstedt, S. L., Georgiadou, A., Apel, F., Abed, U. A., Moxon, C. A., Cunnington, A. J., Raupach, B., Cunningham, D., Langhorne, J., Krüger, R., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aaw0336 · Cited by 177
Self-citationAndrade, C. M., Fleckenstein, H., Thomson-Luque, R., Doumbo, S., Lima, N. F., Anderson, C., Hibbert, J., Hopp, C. S., Tran, T. M., Li, S., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-1084-0 · Cited by 126
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Metadata
- Authors
- Lee, H. J., Georgiadou, A., Walther, M., Nwakanma, D., Stewart, L. B., Levin, M., Otto, T. D., Conway, D. J., Coin, L. J., & Cunnington, A. J.
- Affiliations
- The University of Queensland (AU)
- London School of Hygiene & Tropical Medicine (GB)
- MRC Unit the Gambia (GM)
- Imperial College London (GB)
- Wellcome Sanger Institute (GB)
- Corresponding author
- Cunnington, Aubrey J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2018-06-27
- Volume
- 10
- Issue
- 447
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC6326353
- OpenAlex
- W2766874071
- Cited by
- 141
- References
- 105
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 24 · 2021: 14 · 2020: 23 · 2019: 19 · 2018: 5
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Wellcome Trust (098051)
- Medical Research Council (MR/L006529/1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Keywords
- severe malaria, Plasmodium falciparum, host-pathogen interaction, transcriptome, pathogen load, translation genes, granulopoiesis, interferon-gamma, type I interferon signaling, disease severity, gene co-regulation
- MeSH terms
- Child, Child, Preschool, Female, Gene Expression Regulation, Humans, Male, Neutrophils, Plasmodium falciparum, Species Specificity, Malaria, Falciparum, Sequence Analysis, RNA, Parasitemia, Gene Expression Profiling, Gene Regulatory Networks, Host-Pathogen Interactions
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