Cited by 146Malaria Research and ControlHemoglobinopathies and Related DisordersBird parasitology and diseases

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Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

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Lee, Hyun Jae, Georgiadou, Athina, Walther, Michael, Nwakanma, Davis, Stewart, Lindsay B., Levin, Michael, Otto, Thomas D., Conway, David J., Coin, Lachlan J., Cunnington, Aubrey J.·2018·Science Translational Medicine

DOI 10.1126/scitranslmed.aar3619PMC PMC6326353

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Host and parasite RNA sequencing is combined with parasite load estimates to reveal mechanisms associated with human severe malaria.

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Authors: Lee, H. J., Georgiadou, A., Walther, M., Nwakanma, D., Stewart, L. B., Levin, M., Otto, T. D., Conway, D. J., Coin, L. J., & Cunnington, A. J.
Affiliations: The University of Queensland (AU)
London School of Hygiene & Tropical Medicine (GB)
MRC Unit the Gambia (GM)
Imperial College London (GB)
Wellcome Sanger Institute (GB)
Corresponding author: Cunnington, Aubrey J.
ORCID: Lee, Hyun Jae
Georgiadou, Athina
Walther, Michael
Nwakanma, Davis
Stewart, Lindsay B.
Levin, Michael
Otto, Thomas D.
Conway, David J.
Coin, Lachlan J.
Cunnington, Aubrey J.
Venue: Science Translational Medicine
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2018-06-27
Volume: 10
Issue: 447
ISSN: 1946-6234 (ISSN-L)
1946-6242
DOI: 10.1126/scitranslmed.aar3619
PMC: PMC6326353
OpenAlex: W2766874071
Cited by: 141
References: 105
Citations by year: 2026: 4 · 2025: 11 · 2024: 17 · 2023: 24 · 2022: 24 · 2021: 14 · 2020: 23 · 2019: 19 · 2018: 5
FWCI: 14.75
Type: journal article
Language: en
Open access: green
doi.org
Locations: Science Translational Medicine (publishedVersion)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
Spiral (Imperial College London) (submittedVersion)
Funders: Wellcome Trust (098051)
Medical Research Council (MR/L006529/1)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
Keywords: severe malaria, Plasmodium falciparum, host-pathogen interaction, transcriptome, pathogen load, translation genes, granulopoiesis, interferon-gamma, type I interferon signaling, disease severity, gene co-regulation
MeSH terms: Child, Child, Preschool, Female, Gene Expression Regulation, Humans, Male, Neutrophils, Plasmodium falciparum, Species Specificity, Malaria, Falciparum, Sequence Analysis, RNA, Parasitemia, Gene Expression Profiling, Gene Regulatory Networks, Host-Pathogen Interactions

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Integrated pathogen load and dual transcriptome analysis of systemic host-pathogen interactions in severe malaria

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