Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250 · see citing works

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622 · see citing works

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

Lacy, P. E., & Kostianovsky, M. (1967) · Diabetes · doi:10.2337/diab.16.1.35 · Cited by 2,775 · see citing works

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Waring, M. J., Arrowsmith, J., Leach, A. R., Leeson, P. D., Mandrell, S., Owen, R. M., Pairaudeau, G., Pennie, W. D., Pickett, S. D., Wang, J., et al. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4609 · Cited by 1,450 · see citing works

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

Cook, D., Brown, D., Alexander, R., March, R., Morgan, P., Satterthwaite, G., & Pangalos, M. N. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4309 · Cited by 1,347 · see citing works

Organs-on-chips at the frontiers of drug discovery

Esch, E. W., Bahinski, A., & Huh, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4539 · Cited by 1,185 · see citing works

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

Sato, T., & Clevers, H. (2013) · Science · doi:10.1126/science.1234852 · Cited by 1,170 · see citing works

Lost in translation: animal models and clinical trials in cancer treatment.

(2014) · Europe PMC (PubMed Central) · Cited by 1,033 · see citing works

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

Halldorsson, S., Lucumi, E., Gómez-Sjöberg, R., & Fleming, R. M. T. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2014.07.029 · Cited by 1,027 · see citing works

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993 · see citing works

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

Maschmeyer, I., Lorenz, A. K., Schimek, K., Hasenberg, T., Ramme, A. P., Hübner, J., Lindner, M., Drewell, C., Bauer, S., Thomas, A., et al. (2015) · Lab on a Chip · doi:10.1039/c5lc00392j · Cited by 861 · see citing works

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16630991 · Cited by 843 · see citing works

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Zhang, Y. S., Aleman, J., Shin, S. R., Kilic, T., Kim, D., Mousavi Shaegh, S. A., Massa, S., Riahi, R., Chae, S., Hu, N., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612906114 · Cited by 833 · see citing works

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

Turco, M. Y., Gardner, L., Hughes, J., Cindrová‐Davies, T., Gómez‐Ruíz, M., Farrell, L. E., Hollinshead, M. S., Marsh, S. G. E., Brosens, J. J., Critchley, H., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3516 · Cited by 795 · see citing works

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., Fredriksson Puigvert, L., Dankers, A. C. A., Jacobs, F., Snoeys, J., et al. (2016) · Scientific Reports · doi:10.1038/srep25187 · Cited by 739 · see citing works

Biological implications of polydimethylsiloxane-based microfluidic cell culture

Regehr, K. J., Domenech, M., Koepsel, J. T., Carver, K. C., Ellison-Zelski, S. J., Murphy, W. L., Schuler, L. A., Alarid, E. T., & Beebe, D. J. (2009) · Lab on a Chip · doi:10.1039/b903043c · Cited by 719 · see citing works

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Shrike Zhang, Y., Shin, S.-R., Zhao, L., Aleman, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08879-x · Cited by 623 · see citing works

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

Mathur, A., Loskill, P., Shao, K., Huebsch, N., Hong, S., Marcus, S. G., Marks, N. C., Mandegar, M. A., Conklin, B. R., Lee, L. P., et al. (2015) · Scientific Reports · doi:10.1038/srep08883 · Cited by 527 · see citing works

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

Skardal, A., Shupe, T., & Atala, A. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.07.003 · Cited by 512 · see citing works

An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture

Lee, P. J., Hung, P. J., & Lee, L. P. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21360 · Cited by 507 · see citing works

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

Sung, J. H., Kam, C., & Shuler, M. L. (2010) · Lab on a Chip · doi:10.1039/b917763a · Cited by 485 · see citing works

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Wagner, I., Materne, E.-M., Brincker, S., Süßbier, U., Frädrich, C., Busek, M., Sonntag, F., Sakharov, D. A., Trushkin, E. V., Tonevitsky, A. G., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc50234a · Cited by 476 · see citing works

A microfabricated array bioreactor for perfused 3D liver culture

Powers, M. J., Domanský, K., Mofrad, M. R. K., Kalezi, A., Capitano, A. T., Upadhyaya, A., Kurzawski, P., Wack, K. E., Stolz, D. B., Kamm, R. D., et al. (2002) · Biotechnology and Bioengineering · doi:10.1002/bit.10143 · Cited by 464 · see citing works

Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability

Boretto, M., Cox, B., Noben, M., Hendriks, N., Fassbender, A., Roose, H., Amant, F., Timmerman, D., Tomassetti, C., Vanhie, A., et al. (2017) · Development · doi:10.1242/dev.148478 · Cited by 459 · see citing works

Perfused multiwell plate for 3D liver tissue engineering

Domanský, K., Inman, W., Serdy, J., Dash, A., Lim, M. H. M., & Griffith, L. G. (2009) · Lab on a Chip · doi:10.1039/b913221j · Cited by 446 · see citing works

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

Oleaga, C., Bernabini, C., Smith, A. S. T., Srinivasan, B., Jackson, M., McLamb, W., Platt, V., Bridges, R., Cai, Y., Santhanam, N., et al. (2016) · Scientific Reports · doi:10.1038/srep20030 · Cited by 442 · see citing works

Microfluidic Shear Devices for Quantitative Analysis of Cell Adhesion

Lu, H., Koo, L. Y., Wang, W. M., Lauffenburger, D. A., Griffith, L. G., & Jensen, K. F. (2004) · Analytical Chemistry · doi:10.1021/ac049837t · Cited by 406 · see citing works

Clinical Pharmacokinetics of Diclofenac

Davies, N. M., & Anderson, K. E. (1997) · Clinical Pharmacokinetics · doi:10.2165/00003088-199733030-00003 · Cited by 400 · see citing works

Dendritic cell homeostasis

Merad, M., & Manz, M. G. (2009) · Blood · doi:10.1182/blood-2008-12-180646 · Cited by 395 · see citing works

3D microtumors in vitro supported by perfused vascular networks

Sobrino, A., Phan, D. T. T., Datta, R., Wang, X., Hachey, S. J., Romero-López, M., Gratton, E., Lee, A. P., George, S. C., & Hughes, C. C. W. (2016) · Scientific Reports · doi:10.1038/srep31589 · Cited by 387 · see citing works

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

Chen, M. B., Whisler, J. A., Fröse, J., Yu, C., Shin, Y., & Kamm, R. D. (2017) · Nature Protocols · doi:10.1038/nprot.2017.018 · Cited by 385 · see citing works

Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury

Proctor, W. R., Foster, A. J., Vogt, J., Summers, C., Middleton, B., Pilling, M. A., Shienson, D., Kijanska, M., Ströbel, S., Kelm, J. M., et al. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2002-1 · Cited by 328 · see citing works

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

Schwartz, M. P., Hou, Z., Propson, N. E., Zhang, J., Engstrom, C. J., Costa, V. S., Jiang, P., Nguyen, B. K., Bolin, J. M., Daly, W., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516645112 · Cited by 325 · see citing works

Scaling and systems biology for integrating multiple organs-on-a-chip

Wikswo, J. P., Curtis, E. L., Eagleton, Z. E., Evans, B. C., Kole, A., Hofmeister, L. H., & Matloff, W. J. (2013) · Lab on a Chip · doi:10.1039/c3lc50243k · Cited by 310 · see citing works

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

Viravaidya‐Pasuwat, K., Sin, A., & Shuler, M. L. (2004) · Biotechnology Progress · doi:10.1021/bp0341996 · Cited by 306 · see citing works

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U. (2016) · ALTEX · doi:10.14573/altex.1603161 · Cited by 295 · see citing works

Human Nasal and Tracheo-Bronchial Respiratory Epithelial Cell Culture

Fulcher, M. L., & Randell, S. H. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-125-7_8 · Cited by 285 · see citing works

Development of a microphysiological model of human kidney proximal tubule function

Weber, E. J., Chapron, A., Chapron, B. D., Voellinger, J. L., Lidberg, K. A., Yeung, C. K., Wang, Z., Yamaura, Y., Hailey, D. W., Neumann, T., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.011 · Cited by 275 · see citing works

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models

van Midwoud, P. M., Janse, A., Merema, M. T., Groothuis, G. M. M., & Verpoorte, E. M. J. (2012) · Analytical Chemistry · doi:10.1021/ac300771z · Cited by 274 · see citing works

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Vernetti, L. A., Gough, A., Baetz, N. W., Blutt, S. E., Broughman, J. R., Brown, J. A., Foulke-Abel, J. D., Hasan, N. M., In, J., Kelly, E. J., et al. (2017) · Scientific Reports · doi:10.1038/srep42296 · Cited by 274 · see citing works

Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

Bicker, J., Alves, G., Fortuna, A. C., & Falcão, A. C. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.03.012 · Cited by 264 · see citing works

A microfluidically perfused three dimensional human liver model

Rennert, K., Steinborn, S., Gröger, M., Ungerböck, B., Jank, A., Ehgartner, J., Nietzsche, S., Dinger, J., Kiehntopf, M., Funke, H., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.043 · Cited by 258 · see citing works

The relevance and potential roles of microphysiological systems in biology and medicine

Wikswo, J. P. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214542068 · Cited by 248 · see citing works

A Low Permeability Microfluidic Blood-Brain Barrier Platform with Direct Contact between Perfusable Vascular Network and Astrocytes

Bang, S., Lee, B., Ko, J., Son, K., Tahk, D., Ahn, J., Im, C., & Jeon, N. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-07416-0 · Cited by 247 · see citing works

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

Abaci, H. E., & Shuler, M. L. (2015) · Integrative Biology · doi:10.1039/c4ib00292j · Cited by 243 · see citing works

Design and demonstration of a pumpless 14 compartment microphysiological system

Miller, P. G., & Shuler, M. L. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.25989 · Cited by 235 · see citing works

Functional behavior of primary rat liver cells in a three-dimensional perfused microarray bioreactor

Powers, M. J., Janigian, D. M., Wack, K. E., Baker, C. S., Stolz, D. B., & Griffith, L. G. (2002) · Tissue Engineering · doi:10.1089/107632702760184745 · Cited by 234 · see citing works

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

Esch, M. B., Ueno, H., Applegate, D. R., & Shuler, M. L. (2016) · Lab on a Chip · doi:10.1039/c6lc00461j · Cited by 223 · see citing works

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Tsamandouras, N., Chen, W. L. K., Edington, C. D., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0122-4 · Cited by 222 · see citing works

State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology

Alépée, N. (2014) · ALTEX · doi:10.14573/altex1406111 · Cited by 221 · see citing works

A Comparative Study of Transmembrane Diffusion and Permeation of Ibuprofen across Synthetic Membranes Using Franz Diffusion Cells

Ng, S., Rouse, J. J., Sanderson, D., & Eccleston, G. M. (2010) · Pharmaceutics · doi:10.3390/pharmaceutics2020209 · Cited by 189 · see citing works

Correction: Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Vernetti, L. A., Gough, A., Baetz, N. W., Blutt, S. E., Broughman, J. R., Brown, J. A., Foulke-Abel, J. D., Hasan, N. M., In, J., Kelly, E. J., et al. (2017) · Scientific Reports · doi:10.1038/srep44517 · Cited by 189 · see citing works

Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk

Chen, W. L. K., Edington, C., Suter, E., Yu, J., Velazquez, J. J., Velazquez, J. G., Shockley, M., Large, E. M., Venkataramanan, R., Hughes, D. J., et al. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26370 · Cited by 171 · see citing works

Prediction of Hepatic Clearance and Availability by Cryopreserved Human Hepatocytes: An Application of Serum Incubation Method

Shibata, Y., Takahashi, H., Chiba, M., & Ishii, Y. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.8.892 · Cited by 170 · see citing works

Liver tissue engineering in the evaluation of drug safety

Dash, A., Inman, W., Hoffmaster, K. A., Sevidal, S., Kelly, J., Obach, R. S., Griffith, L. G., & Tannenbaum, S. R. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903160664 · Cited by 156 · see citing works

How multi-organ microdevices can help foster drug development

Esch, M. B., Smith, A. S. T., Prot, J. M., Oleaga, C., Hickman, J. J., & Shuler, M. L. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.003 · Cited by 154 · see citing works

Physiologically relevant organs on chips

Yum, K., Hong, S. G., Healy, K. E., & Lee, L. P. (2013) · Biotechnology Journal · doi:10.1002/biot.201300187 · Cited by 151 · see citing works

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

Kostrzewski, T. M., Cornforth, T. V., Snow, S., Ouro-Gnao, L., Rowe, C., Large, E. M., & Hughes, D. J. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i2.204 · Cited by 149 · see citing works

Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces

Kaigala, G. V., Lovchik, R. D., & Delamarche, E. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201201798 · Cited by 142 · see citing works

μOrgano: A Lego®-Like Plug & Play System for Modular Multi-Organ-Chips

Loskill, P., Marcus, S. G., Mathur, A., Reese, W. M., & Healy, K. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139587 · Cited by 123 · see citing works

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

Tsamandouras, N., Kostrzewski, T. M., Stokes, C. L., Griffith, L. G., Hughes, D. J., & Cirit, M. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237495 · Cited by 119 · see citing works

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

Dash, A., Simmers, M. B., Deering, T. G., Berry, D. J., Feaver, R. E., Hastings, N. E., Pruett, T. L., LeCluyse, E. L., Blackman, B. R., & Wamhoff, B. R. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00331.2012 · Cited by 108 · see citing works

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Dehne, E., Maschmeyer, I., Lorenz, A., Horland, R., Schimek, K. M. S., Busek, M., Sonntag, F., Lauster, R., & Marx, U. (2015) · Journal of Visualized Experiments · doi:10.3791/52526 · Cited by 106 · see citing works

WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue

Loskill, P., Thiagarajan, S., Tharp, K. M., Lee-Montiel, F. T., Jeeawoody, S., Reese, W. M., Zushin, P. H., Stahl, A., & Healy, K. E. (2017) · Lab on a Chip · doi:10.1039/c6lc01590e · Cited by 106 · see citing works

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

Wheeler, S., Clark, A. M., Taylor, D. P., Young, C. L., Pillai, V. C., Stolz, D. B., Venkataramanan, R., Lauffenburger, D. A., Griffith, L. G., & Wells, A. H. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.533 · Cited by 102 · see citing works

Design, modeling and fabrication of a constant flow pneumatic micropump

Inman, W., Domanský, K., Serdy, J., et al. (2007) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/17/5/007 · Cited by 94 · see citing works

Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Long, T. J., Cosgrove, P. A., Dunn, R. T., Stolz, D. B., Hamadeh, H. K., Afshari, C. A., McBride, H. J., & Griffith, L. G. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.071456 · Cited by 94 · see citing works

Development of a serum-free co-culture of human intestinal epithelium cell-lines (Caco-2/HT29-5M21)

Nollevaux, G., Devillé, C., Moualij, B. E., Zorzi, W., Deloyer, P., Schneider, Y., Peulen, O., & Dandrifosse, G. (2006) · BMC Cell Biology · doi:10.1186/1471-2121-7-20 · Cited by 93 · see citing works

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function

Cook, C. D., Hill, A. S., Guo, M. G., Stockdale, L., Papps, J. P., Isaacson, K., Lauffenburger, D. A., & Griffith, L. G. (2017) · Integrative Biology · doi:10.1039/c6ib00245e · Cited by 93 · see citing works

On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks

Valdez, J., Cook, C. D., Ahrens, C. C., Wang, A. J.-S., Brown, A., Kumar, M. P., Stockdale, L., Rothenberg, D., Renggli, K., Gordon, E. A., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.030 · Cited by 92 · see citing works

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

Prot, J. M., Maciel, L., Bricks, T., Merlier, F., Cotton, J., Paullier, P., Bois, F. Y., & Leclerc, E. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25232 · Cited by 89 · see citing works

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue

Fabre, K. M., Livingston, C., & Tagle, D. A. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214538916 · Cited by 82 · see citing works

Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus

Wira, C. R., Ghosh, M., Smith, J. M., Shen, L., Connor, R. I., Sundstrom, P., Frechette, G. M., Hill, E. T., & Fahey, J. V. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.72 · Cited by 74 · see citing works

Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease

Abaci, H. E., Shen, Y., Tan, S., & Gerecht, S. (2014) · Scientific Reports · doi:10.1038/srep04951 · Cited by 72 · see citing works

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

Maass, C., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · Integrative Biology · doi:10.1039/c6ib00243a · Cited by 72 · see citing works

The Ascendance of Microphysiological Systems to Solve the Drug Testing Dilemma

Dehne, E., Hasenberg, T., & Marx, U. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0002 · Cited by 70 · see citing works

High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model

Conant, G., Lai, B. F. L., Lu, R. X. Z., Korolj, A., Wang, E. Y., & Radisic, M. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9736-2 · Cited by 67 · see citing works

Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

Vivarès, A., Salle-Lefort, S., Arabeyre‐Fabre, C., Ngo, R., Pénarier, G., Bremond, M., Moliner, P., Gallas, J., Fabre, G., & Klieber, S. (2014) · Xenobiotica · doi:10.3109/00498254.2014.944612 · Cited by 64 · see citing works

Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations

Blanchard, N., Hewitt, N. J., Silber, P. M., Jones, H. M., Coassolo, P., & Lavé, T. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.5.0008 · Cited by 63 · see citing works

Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production

Chen, J. C., Erikson, D. W., Piltonen, T., et al. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.06.007 · Cited by 53 · see citing works

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi‐MPS Integration

Yu, J., Cilfone, N., Large, E. M., Sarkar, U., Wishnok, J. S., Tannenbaum, S. R., Hughes, D., Lauffenburger, D. A., Griffith, L. G., Stokes, C., et al. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12010 · Cited by 52 · see citing works

Physiologically relevant human tissue models for infectious diseases

Mills, M., & Estes, M. K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.06.020 · Cited by 50 · see citing works

Physiome‐on‐a‐Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems

Stokes, C., Cirit, M., & Lauffenburger, D. A. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12042 · Cited by 49 · see citing works

Allometric Scaling and Cell Ratios in Multi-Organ in vitro Models of Human Metabolism

Ucciferri, N., Sbrana, T., & Ahluwalia, A. D. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00074 · Cited by 46 · see citing works

Organs on Chips 2013

Beebe, D. J., Ingber, D. E., & den Toonder, J. M. J. (2013) · Lab on a Chip · doi:10.1039/c3lc90080k · Cited by 41 · see citing works

Creating Multiple Organotypic Models on a Single 3D Cell Culture Platform

Lim, S. H., & Pavesi, A. (2017) · BioTechniques · doi:10.2144/000114526 · Cited by 2 · see citing works

Human organs-on-chips for disease modelling, drug development and personalized medicine

Ingber, D. E. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00466-9 · Cited by 1,589 · see citing works

A guide to the organ-on-a-chip

Leung, C. M., de Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H. S., Chen, Z., Habibovic, P., Jeon, N. L., Takayama, S., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00118-6 · Cited by 1,116 · see citing works

Organs-on-chips: into the next decade

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029 · see citing works

Modelling cancer in microfluidic human organs-on-chips

Sontheimer-Phelps, A., Hassell, B. A., & Ingber, D. E. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-018-0104-6 · Cited by 906 · see citing works

Human disease models in drug development

Loewa, A., Feng, J. J., & Hedtrich, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00063-3 · Cited by 331 · see citing works

Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery

Sharma, A., Sances, S., Workman, M. J., & Svendsen, C. N. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.011 · Cited by 296 · see citing works

Tumor-on-a-chip: from bioinspired design to biomedical application

Liu, X., Fang, J., Huang, S., Wu, X., Xie, X., Wang, J., Liu, F., Zhang, M., Peng, Z., & Hu, N. (2021) · Microsystems & Nanoengineering · doi:10.1038/s41378-021-00277-8 · Cited by 246 · see citing works

Organs-on-a-chip models for biological research

Vunjak-Novakovic, G., Ronaldson-Bouchard, K., & Radisic, M. (2021) · Cell · doi:10.1016/j.cell.2021.08.005 · Cited by 248 · see citing works

Cardiovascular disease models: A game changing paradigm in drug discovery and screening

Savoji, H., Mohammadi, M. H., Rafatian, N., Toroghi, M. K., Wang, E. Y., Zhao, Y., Korolj, A., Ahadian, S., & Radisic, M. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.09.036 · Cited by 223 · see citing works

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

McAleer, C. W., Long, C. J., Elbrecht, D., Sasserath, T., Bridges, L. R., Rumsey, J. W., Martin, C., Schnepper, M., Wang, Y., Schuler, F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav1386 · Cited by 199 · see citing works

Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

Trapecar, M., Wogram, E., Svoboda, D., Communal, C., Omer, A., Lungjangwa, T., Sphabmixay, P., Velazquez, J., Schneider, K., Wright, C. W., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd1707 · Cited by 176 · see citing works

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

Baudy, A. R., Otieno, M. A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T. R., & Proctor, W. R. (2020) · Lab on a Chip · doi:10.1039/c9lc00768g · Cited by 150 · see citing works

Applications of tumor chip technology

Hachey, S. J., & Hughes, C. C. W. (2018) · Lab on a Chip · doi:10.1039/c8lc00330k · Cited by 128 · see citing works

Human biomimetic liver microphysiology systems in drug development and precision medicine

Gough, A., Soto-Gutierrez, A., Vernetti, L., Ebrahimkhani, M. R., Stern, A. M., & Taylor, D. L. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00386-1 · Cited by 117 · see citing works

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Park, D., Lee, J., Chung, J. J., Jung, Y., & Kim, S. H. (2020) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.06.006 · Cited by 105 · see citing works

Towards in vitro models for reducing or replacing the use of animals in drug testing

Stresser, D. M., Kopec, A. K., Hewitt, P., Hardwick, R. N., Van Vleet, T. R., Mahalingaiah, P. K. S., O’Connell, D., Jenkins, G. J., David, R., Graham, J., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01154-7 · Cited by 94 · see citing works

Microfluidic high-throughput 3D cell culture

Ko, J., Park, D., Lee, J., Jung, S., Baek, K., Sung, K. E., Lee, J., & Jeon, N. L. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00163-8 · Cited by 88 · see citing works

Engineering microphysiological immune system responses on chips

Miller, C. P., Shin, W., Ahn, E. H., Kim, H. J., & Kim, D.-H. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.01.003 · Cited by 74 · see citing works

Recommended guidelines for developing, qualifying, and implementing complex in vitro models (CIVMs) for drug discovery

Ekert, J. E., Deakyne, J., Pribul-Allen, P., Terry, R., Schofield, C., Jeong, C. G., Storey, J., Mohamet, L., Francis, J., Naidoo, A., et al. (2020) · SLAS DISCOVERY · doi:10.1177/2472555220923332 · Cited by 68 · see citing works

Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine

Huang, D. (., Gibeley, S. B., Xu, C., Xiao, Y., Celik, O., Ginsberg, H. N., & Leong, K. W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909553 · Cited by 65 · see citing works

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

Kostrzewski, T., Snow, S., Battle, A. L., Peel, S., Ahmad, Z., Basak, J., Surakala, M., Bornot, A., Lindgren, J., Ryaboshapkina, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02616-x · Cited by 52 · see citing works

A framework for developing sex-specific engineered heart models

Lock, R., Al Asafen, H., Fleischer, S., Tamargo, M., Zhao, Y., Radisic, M., & Vunjak-Novakovic, G. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00381-1 · Cited by 50 · see citing works

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Malik, M., Yang, Y., Fathi, P., Mahler, G. J., & Esch, M. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.721338 · Cited by 43 · see citing works

Alternative strategies in cardiac preclinical research and new clinical trial formats

Kreutzer, F. P., Meinecke, A., Schmidt, K., Fiedler, J., & Thum, T. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvab075 · Cited by 36 · see citing works

Liver organoids: Current advances and future applications for hepatology

Kim, Y., Kang, M., Mamo, M. G., Adisasmita, M., Huch, M., & Choi, D. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.1040 · Cited by 26 · see citing works

Microfluidic-based prostate cancer model for investigating the secretion of prostate-specific antigen and microRNAs in vitro

Padmyastuti, A., Sarmiento, M. G., Dib, M., Ehrhardt, J., Schoon, J., Somova, M., Burchardt, M., Roennau, C., & Pinto, P. C. (2023) · Scientific Reports · doi:10.1038/s41598-023-38834-y · Cited by 17 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

A comparison of in vivo and in vitro methods for determining availability of iron from meals

Schricker, B. R., Miller, D. D., Rasmussen, R. R., et al. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.10.2257 · Cited by 110 · see citing works

Studies on pharmacokinetics of sulfonated aluminum phthalocyanine in a transplantable mouse tumor by in vivo fluorescence

Chen, J.-Y., Chen, W., Cai, H.-X., et al. (1993) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(93)80069-l · Cited by 8 · see citing works

Using DataGrid Control to Realize DataBase of Querying in VB6.0

Hu, S. (2000) · Modern Computer

Study and Two Types of Typical Usage of DataGrid Web Server Control

Hai-tao, L. (2005) · Modern Computer