The DOI matches its Crossref record; 90 of the 91 references it cites were found in a registry or an index.
An ocular glymphatic clearance system removes β-amyloid from the rodent eye
Open accessAbstract
Glymphatic pathway clears retinal β-amyloid in rodents via optic nerve and is impaired in glaucoma.
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“fluid transport through the glymphatic system is directionally polarized, with influx along penetrating arteries, fluid entry into the neuropil supported by AQP4, and efflux along the peri-venous spaces, as well as along the cranial and spinal nerves (24, 32–34).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [33]
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Cites
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Self-citationSleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Self-citationStructural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413
The Pathophysiology and Treatment of Glaucoma: A Review
Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210
Pericytes regulate the blood–brain barrier
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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198
Motulsky, H. J., & Brown, R. E. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-123 · Cited by 1,616
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565
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Research works printed but not linked: 1
- A. K. Palkama, D. Velasquez, J. Reynaud, H. W. Thompson, R. W. Beuerman, Regulatory effect of pilocarpine and/or atropine on the facility of outflow in perfused bovine anterior eye segments and intact trabecular meshwork and ciliary. Invest. Ophthalmol. Vis. Sci. 43, U900 (2002).
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Glymphatic failure as a final common pathway to dementia
Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145
Self-citationRasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 642
Self-citationThe Glymphatic System: A Novel Component of Fundamental Neurobiology
Hablitz, L. M., & Nedergaard, M. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0619-21.2021 · Cited by 503
Self-citationSolving neurodegeneration: common mechanisms and strategies for new treatments
Wareham, L. K., Liddelow, S. A., Temple, S., Benowitz, L. I., Di Polo, A., Wellington, C., Goldberg, J. L., He, Z., Duan, X., Bu, G., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00524-0 · Cited by 324
The glymphatic system: implications for drugs for central nervous system diseases
Lohela, T. J., Lilius, T. O., & Nedergaard, M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00500-9 · Cited by 254
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Metadata
- Authors
- Wang, X., Lou, N., Eberhardt, A., Yang, Y., Kusk, P., Xu, Q., Förstera, B., Peng, S., Shi, M., Ladrón-de-Guevara, A., Delle, C., Sigurdsson, B., Xavier, A. L. R., Ertürk, A., Libby, R. T., Chen, L., Thrane, A. S., & Nedergaard, M.
- Affiliations
- University of Copenhagen (DK)
- University of Rochester Medicine (US)
- University of California, Berkeley (US)
- Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians University of Munich (LMU), 81377 Munich, Germany.
- Helmholtz Munich (DE)
- Corresponding author
- Chen, Lu
- Nedergaard, Maiken
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-03-25
- Volume
- 12
- Issue
- 536
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7356596
- OpenAlex
- W3013081630
- Cited by
- 239
- References
- 91
- Citations by year
- 2026: 35 · 2025: 50 · 2024: 48 · 2023: 27 · 2022: 24 · 2021: 34 · 2020: 20
- FWCI
- 20.82
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- National Institutes of Health (AG057575, NS100366, EY028995)
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Cure Alzheimer’s Fund
- H2020 European Research Council (742112)
- Lundbeckfonden
- Novo Nordisk Fonden
- Research to Prevent Blindness Foundation (Stein Innovation Award)
- Western Norway Regional Health Authority (Helse Vest grants no. 912179 and 912230)
- Norwegian Glaucoma Research Foundation
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- amyloid-beta clearance, aquaporin-4, optic nerve, glaucoma, intraocular pressure, miosis, vitreous humor, lymphatic drainage, retina
- MeSH terms
- Glymphatic System, Animals, Intracranial Pressure, Optic Nerve, Retina, Vitreous Body, Amyloid beta-Peptides, Mice, Aquaporin 4
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