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The Pathophysiology and Treatment of Glaucoma: A Review

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Pericytes regulate the blood–brain barrier

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A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

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Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

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Relationship Between Intraocular Pressure and Primary Open Angle Glaucoma Among White and Black Americans

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The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage

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Glymphatic failure as a final common pathway to dementia

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Fluid transport in the brain

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The Glymphatic System: A Novel Component of Fundamental Neurobiology

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Solving neurodegeneration: common mechanisms and strategies for new treatments

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The glymphatic system: implications for drugs for central nervous system diseases

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The Glymphatic System (En)during Inflammation

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Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline

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Alzheimer’s Retinopathy: Seeing Disease in the Eyes

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Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma

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The Glymphatic System: A Review of the Challenges in Visualizing its Structure and Function with MR Imaging

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The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging

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Glymphatic System as a Gateway to Connect Neurodegeneration From Periphery to CNS

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Compartmentalized ocular lymphatic system mediates eye–brain immunity

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Alzheimer's disease pathophysiology in the Retina

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Retinal Vasculopathy in Alzheimer’s Disease

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Imaging for central nervous system (CNS) interstitial fluidopathy: disorders with impaired interstitial fluid dynamics

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Whole-mouse clearing and imaging at the cellular level with vDISCO

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Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications

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Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ ISMRM Imaging Neurofluids Study group” Workshop in Rome

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Ocular Nanomedicine

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Transport of β-amyloid from brain to eye causes retinal degeneration in Alzheimer’s disease

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Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

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Glymphatic system dysfunction in neurodegenerative diseases

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Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice

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Redefining our vision: an updated guide to the ocular immune system

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Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood

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Effects of spaceflight on the brain

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Signalling pathways and cell death mechanisms in glaucoma: Insights into the molecular pathophysiology

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Brain Glymphatic/Lymphatic Imaging by MRI and PET

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Longitudinal Development of Peripapillary Hyper‐Reflective Ovoid Masslike Structures Suggests a Novel Pathological Pathway in Multiple Sclerosis

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The lymphatic system: a therapeutic target for central nervous system disorders

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The Ocular Glymphatic System—Current Understanding and Future Perspectives

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Multirater Validation of Peripapillary Hyperreflective Ovoid Mass-like Structures (PHOMS)

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Artificial Intelligence Frameworks to Detect and Investigate the Pathophysiology of Spaceflight Associated Neuro-Ocular Syndrome (SANS)

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Cerebrospinal fluid dynamics along the optic nerve

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Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease

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Retinal Amyloid Imaging for Screening Alzheimer’s Disease

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An explanation for Terson syndrome at last: the glymphatic reflux theory

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Breaking a Vicious Circle: Lymphangiogenesis as a New Therapeutic Target in Wound Healing

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Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

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Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?

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MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity

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Preserving blood-retinal barrier integrity: a path to retinal ganglion cell protection in glaucoma and traumatic optic neuropathy

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Ocular Lymphatic and Glymphatic Systems: Implications for Retinal Health and Disease

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Age- and glaucoma-induced changes to the ocular glymphatic system

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In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus

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Mixed pathology as a rule, not exception: Time to reconsider disease nosology

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Glymphatic imaging and modulation of the optic nerve

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Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis

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The diagnostic value of the IDEAL-T2WI sequence in dysthyroid optic neuropathy: a quantitative analysis of the optic nerve and cerebrospinal fluid in the optic nerve sheath

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Fluid dynamics in aging-related dementias

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Large molecules from the cerebrospinal fluid enter the optic nerve but not the retina of mice

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Twists and turns of ocular glymphatic clearance – new study reveals surprising findings in glaucoma

Thrane, V. R., Hynnekleiv, L., Wang, X., Thrane, A. S., Krohn, J., & Nedergaard, M. (2020) · Acta Ophthalmologica · doi:10.1111/aos.14524 · Cited by 25

Potential Involvement of the Ocular Glymphatic System in Optic Disc Edema in Astronauts

Wostyn, P., Winne, F. D., Stern, C., Mader, T. H., Gibson, C. R., & Deyn, P. P. D. (2020) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.5670.2020 · Cited by 25

AQP4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating TRPV4

Chen, Z., Liu, B., Zhou, D., Lei, M., Yang, J., Hu, Z., & Duan, W. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114087 · Cited by 24

The role and mechanism of Aβ clearance dysfunction in the glymphatic system in Alzheimer’s disease comorbidity

Li, H., Yao, Q., Huang, X., Yang, X., & Yu, C. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1474439 · Cited by 26

White matter alterations in glaucoma and monocular blindness differ outside the visual system

Hanekamp, S., Ćurĉić‐Blake, B., Caron, B. A., McPherson, B., Timmer, A., Prins, D., Boucard, C. C., Yoshida, M., Ida, M., Hunt, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85602-x · Cited by 24

Lymphatics in Eye Fluid Homeostasis: Minor Contributors or Significant Actors?

Subileau, M., & Vittet, D. (2021) · Biology · doi:10.3390/biology10070582 · Cited by 22

The odyssey of the ocular and cerebrospinal fluids during a mission to Mars: the “ocular glymphatic system” under pressure

Wostyn, P., Gibson, C. R., & Mader, T. H. (2021) · Eye · doi:10.1038/s41433-021-01721-9 · Cited by 22

Cognitive Dysfunctions in Glaucoma: An Overview of Morpho-Functional Mechanisms and the Impact on Higher-Order Visual Function

Arrigo, A., Aragona, E., Saladino, A., Arrigo, D., Fantaguzzi, F., Parodi, M. B., & Bandello, F. M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.747050 · Cited by 23

Do normal-tension and high-tension glaucoma result from brain and ocular glymphatic system disturbances, respectively?

Wostyn, P. (2020) · Eye · doi:10.1038/s41433-020-01219-w · Cited by 21

Progress on Brain and Ocular Lymphatic System

Xu, Y., Cheng, L., Lu, Y., Yi, Q., Xiao, L., & Chen, H. (2022) · BioMed Research International · doi:10.1155/2022/6413553 · Cited by 21

Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

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Spaceflight Associated Neuro-ocular Syndrome (SANS) and its countermeasures

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The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature

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Ocular manifestations of central insulin resistance

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NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury

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Lipid mediators in glaucoma: Unraveling their diverse roles and untapped therapeutic potential

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Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways

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Peripheral Retinal Leakage after Intravenous Administration of a Gadolinium-based Contrast Agent: Age Dependence, Temporal and Inferior Predominance and Potential Implications for Eye Homeostasis

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Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation

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Noninvasive investigations of human glymphatic dynamics in a diseased model

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Interleukin-17-mediated protective cytokine signaling against degeneration of the retinal pigment epithelium

Chen, Y., Bounds, S. E., Ma, X., Karmoker, J. R., Liu, Y., Ma, J., & Cai, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2311647120 · Cited by 14

The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma

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Optic Disc Edema in Astronauts from a Choroidal Point of View

Wostyn, P., Gibson, C. R., & Mader, T. H. (2022) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.6010.2022 · Cited by 16

Clearance of neurotoxic peptides and proteins by meningothelial cells

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Retinal Vascular Pathology in a Rat Model of Cerebral Small Vessel Disease

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