An ocular glymphatic clearance system removes β-amyloid from the rodent eye

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413

The Pathophysiology and Treatment of Glaucoma: A Review

Weinreb, R. N., Aung, T., & Medeiros, F. A. (2014) · JAMA · doi:10.1001/jama.2014.3192 · Cited by 4,210

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198

Detecting outliers when fitting data with nonlinear regression – a new method based on robust nonlinear regression and the false discovery rate

Motulsky, H. J., & Brown, R. E. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-123 · Cited by 1,616

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565

Relationship Between Intraocular Pressure and Primary Open Angle Glaucoma Among White and Black Americans

Sommer, A. H. (1991) · Archives of Ophthalmology · doi:10.1001/archopht.1991.01080080050026 · Cited by 1,178

The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage

Burgoyne, C. F., Downs, J. C., Bellezza, A. J., Suh, J.-K. F., & Hart, R. T. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.06.001 · Cited by 1,142

Interstitial-lymphatic mechanisms in the control of extracellular fluid volume

Aukland, K., & Reed, R. K. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.1 · Cited by 938

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

Mathiisen, T. M., Lehre, K. P., Danbolt, N. C., & Ottersen, O. (2010) · Glia · doi:10.1002/glia.20990 · Cited by 893

Aqueous Humor Dynamics: A Review

Goel, M., Picciani, R. G., Lee, R. K., & Bhattacharya, S. K. (2010) · The Open Ophthalmology Journal · doi:10.2174/1874364101004010052 · Cited by 891

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., et al. (2019) · Science · doi:10.1126/science.aav2546 · Cited by 813

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Ahn, J. H., Cho, H., Kim, J.-H., Kim, S. H., Ham, J.-S., Park, I., Suh, S. H., Hong, S. P., Song, J.-H., Hong, Y.-K., et al. (2019) · Nature · doi:10.1038/s41586-019-1419-5 · Cited by 811

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife · doi:10.7554/elife.40070 · Cited by 738

Glymphatic MRI in idiopathic normal pressure hydrocephalus

Ringstad, G., Vatnehol, S. A. S., & Eide, P. K. (2017) · Brain · doi:10.1093/brain/awx191 · Cited by 722

Garbage Truck of the Brain

Nedergaard, M. (2013) · Science · doi:10.1126/science.1240514 · Cited by 718

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

Ma, Q., Ineichen, B. V., Detmar, M., & Proulx, S. T. (2017) · Nature Communications · doi:10.1038/s41467-017-01484-6 · Cited by 690

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI.

Absinta, M., Ha, S.-K., Nair, G., Sati, P., Luciano, N. J., Palisoc, M., Louveau, A., Zaghloul, K. A., Pittaluga, S., Kipnis, J., et al. (2017) · eLife · doi:10.7554/elife.29738 · Cited by 643

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

Pan, C., Cai, R., Quacquarelli, F. P., Ghasemigharagoz, A., Lourbopoulos, A. I., Matryba, P., Plesnila, N., Dichgans, M., Hellal, F., & Ertürk, A. (2016) · Nature Methods · doi:10.1038/nmeth.3964 · Cited by 621

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

Williams, P. A., Harder, J. M., Foxworth, N. E., Cochran, K. E., Philip, V. M., Porciatti, V., Smithies, O., & John, S. W. M. (2017) · Science · doi:10.1126/science.aal0092 · Cited by 617

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Peng, W., Achariyar, T. M., Li, B., Liao, Y., Mestre, H., Hitomi, E., Regan, S., Kasper, T., Peng, S., Ding, F., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.05.015 · Cited by 580

Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease

Koronyo, Y., Biggs, D., Barrón, E., Boyer, D. S., Pearlman, J. A., Au, W. J., Kile, S. J., Blanco, A., Fuchs, D.-T. S., Ashfaq, A., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93621 · Cited by 521

The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina

Rodriguez, A. R., de Sevilla Müller, L. P., & Brecha, N. C. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23521 · Cited by 483

Aquaporin-4 Water Channel Protein in the Rat Retina and Optic Nerve: Polarized Expression in Müller Cells and Fibrous Astrocytes

Nagelhus, E. A., Veruki, M. L., Torp, R., Haug, F. Š., Laake, J. H., Nielsen, S. M., Agre, P. C., & Ottersen, O. P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02506.1998 · Cited by 459

Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice

Anderson, M. G., Smith, R. S., Hawes, N. L., Zabaleta, A., Chang, B., Wiggs, J. L., & John, S. W. M. (2001) · Nature Genetics · doi:10.1038/ng794 · Cited by 453

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

Kiviniemi, V., Wang, X., Korhonen, V., Keinänen, T., Tuovinen, T., Autio, J., LeVan, P., Keilholz, S., Zang, Y.-F., Hennig, J., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15622047 · Cited by 453

Progressive Ganglion Cell Degeneration Precedes Neuronal Loss in a Mouse Model of Glaucoma

Buckingham, B. P., Inman, D. M., Lambert, W. S., Oglesby, E., Calkins, D. J., Steele, M. R., Vetter, M. L., Marsh‐Armstrong, N., & Horner, P. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4443-07.2008 · Cited by 410

Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration

Libby, R. T., Anderson, M. G., Pang, I., ROBINSON, Z. H., SAVINOVA, O. V., Cosma, I. M., Snow, A., Wilson, L. A., Smith, R. S., Clark, A. F., et al. (2005) · Visual Neuroscience · doi:10.1017/s0952523805225130 · Cited by 410

Characterization of β amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

Anderson, D. H., Talaga, K. C., Rivest, A. J., Barron, E., Hageman, G. S., & Johnson, L. V. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2003.10.011 · Cited by 319

Magnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes

Eide, P. K., Vatnehol, S. A. S., Emblem, K. E., & Ringstad, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-25666-4 · Cited by 299

Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

Kanekiyo, T., Cirrito, J. R., Liu, C.-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M., & Bu, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-13.2013 · Cited by 280

Sensitive blood-retinal barrier breakdown quantitation using Evans blue.

Xu, Q., Qaum, T., & Adamis, A. P. (2001) · PubMed · Cited by 273

Extrasynaptic volume transmission and diffusion parameters of the extracellular space

Syková, E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.077 · Cited by 270

Critical role of aquaporin-4 (AQP4) in astrocytic Ca 2+ signaling events elicited by cerebral edema

Thrane, A. S., Rappold, P. M., Fujita, T., Torres, A., Bekar, L. K., Takano, T., Peng, W., Wang, F., Rangroo Thrane, V., Enger, R., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015217108 · Cited by 254

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

Yamamoto, K., Tanei, Z., Hashimoto, T., Wakabayashi, T., Okuno, H., Naka, Y., Yizhar, O., Fenno, L. E., Fukayama, M., Bito, H., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.017 · Cited by 225

Unconventional aqueous humor outflow: A review

Johnson, M., McLaren, J. W., & Overby, D. R. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.01.017 · Cited by 224

Remodeling of the Connective Tissue Microarchitecture of the Lamina Cribrosa in Early Experimental Glaucoma

Roberts, M. D., Grau, V., Grimm, J. L., Reynaud, J. F., Bellezza, A. J., Burgoyne, C. F., & Downs, J. C. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1792 · Cited by 207

Ion-selective microelectrodes and diffusion measurements as tools to explore the brain cell microenvironment

Nicholson, C. (1993) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(93)90092-6 · Cited by 203

Evidence for Cerebrospinal Fluid Entry Into the Optic Nerve via a Glymphatic Pathway

Mathieu, E., Gupta, N., Ahari, A., Zhou, X., Hanna, J., & Yücel, Y. H. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22290 · Cited by 176

Identification of lymphatics in the ciliary body of the human eye: A novel “uveolymphatic” outflow pathway

Yücel, Y. H., Johnston, M. G., Ly, T., Patel, M., Drake, B., Gümüş, E., Fraenkl, S. A., Moore, S., Tobbia, D., Armstrong, D., et al. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.08.010 · Cited by 174

Intraocular Pressure Elevation Induces Mitochondrial Fission and Triggers OPA1 Release in Glaucomatous Optic Nerve

Ju, W., Keun-young Kim, A., Lindsey, J. D., Angert, M., Duong‐Polk, K., Scott, R. T., Kim, J. J., Kukhmazov, I., Ellisman, M. H., Perkins, G. A., et al. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1661 · Cited by 171

Intraocular pressure in inbred mouse strains

Smithes, O., Hagaman, J. R., Peng, L., John, S. W. M., & MacTaggart, T. E. (2021) · PubMed · doi:10.17615/qp9a-ds02 · Cited by 168

Lymphatic Capillaries in the Meninges of the Human Optic Nerve

Killer, H. E., Laeng, H. R., & Groscurth, P. (1999) · Journal of Neuro-Ophthalmology · doi:10.1097/00041327-199912000-00002 · Cited by 150

Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina.

Löffler, K. U., Edward, D. P., & Tso, M. O. M. (1995) · PubMed · Cited by 144

Differential Arterial/Venous Expression of NG2 Proteoglycan in Perivascular Cells Along Microvessels: Identifying a Venule‐Specific Phenotype

Murfee, W. L., Skalak, T. C., & Peirce, S. M. (2005) · Microcirculation · doi:10.1080/10739680590904955 · Cited by 140

The mouse anterior chamber angle and trabecular meshwork develop without cell death

Smith, R. S., Zabaleta, A., Savinova, O. V., & John, S. W. M. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-3 · Cited by 139

A new glaucoma hypothesis: a role of glymphatic system dysfunction

Wostyn, P., Dam, D. V., Audenaert, K., Killer, H. E., Deyn, P. P. D., & Groot, V. D. (2015) · Fluids and Barriers of the CNS · doi:10.1186/s12987-015-0012-z · Cited by 137

Direct immunogold labeling of connexins and aquaporin-4 in freeze-fracture replicas of liver, brain, and spinal cord: factors limiting quantitative analysis

Rash, J. E., & Yasumura, T. (1999) · Cell and Tissue Research · doi:10.1007/s004410051291 · Cited by 114

On the hydraulic suspension theory of accommodation.

Coleman, D. J. (1986) · PubMed · Cited by 111

Identification of Human Orbital Lymphatics

Gausas, R. E., Gonnering, R. S., Lemke, B. N., Dortzbach, R. K., & Sherman, D. D. (1999) · Ophthalmic Plastic and Reconstructive Surgery · doi:10.1097/00002341-199907000-00006 · Cited by 102

Circulation and axonal transport in the optic nerve

Morgan, J. P. (2004) · Eye · doi:10.1038/sj.eye.6701574 · Cited by 95

The Outflow Pathway: A Tissue With Morphological and Functional Unity

Saccà, S. C., Gandolfi, S., Bagnis, A., Manni, G., Damonte, G., Traverso, C. E., & Izzotti, A. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25305 · Cited by 83

Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype

Wang, R., Seifert, P. A., & Jakobs, T. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20571 · Cited by 82

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

Fernandes, K. A., Harder, J. M., Williams, P. A., Rausch, R. L., Kiernan, A. E., Nair, K. S., Anderson, M. G., John, S. W. M., Howell, G. R., & Libby, R. T. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.06.019 · Cited by 81

Glymphatic stasis at the site of the lamina cribrosa as a potential mechanism underlying open‐angle glaucoma

Wostyn, P., Killer, H. E., & Deyn, P. P. D. (2017) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12915 · Cited by 77

Paravascular Pathways in the Eye: Is There an ‘Ocular Glymphatic System'?

Denniston, A. K., & Keane, P. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17243 · Cited by 73

Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study

Malmqvist, L., Li, X. Q., Eckmann‐Hansen, C., Skovgaard, A. M., Olsen, E. M., Larsen, M., Munch, I. C., & Hamann, S. (2017) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0000000000000567 · Cited by 73

The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease

Wostyn, P., Groot, V. D., Dam, D. V., Audenaert, K., Killer, H. E., & Deyn, P. P. D. (2017) · BioMed Research International · doi:10.1155/2017/5123148 · Cited by 70

Astrocyte Processes Label for Filamentous Actin and Reorient Early Within the Optic Nerve Head in a Rat Glaucoma Model

Tehrani, S., Johnson, E. C., Cepurna, W. O., & Morrison, J. C. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14969 · Cited by 69

Ocular lymphatics: state-of-the-art review.

Chen, L. (2009) · PubMed · Cited by 67

In Vivo Imaging of Lymphatic Drainage of Cerebrospinal Fluid in Mouse

Mathieu, E., Gupta, N., Macdonald, R. L., Ai, J., & Yücel, Y. H. (2013) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-10-35 · Cited by 66

The Glymphatic System: A New Player in Ocular Diseases?

Wostyn, P., Groot, V. D., Dam, D. V., Audenaert, K., Deyn, P. P. D., & Killer, H. E. (2016) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20262 · Cited by 65

Changes in intraocular pressure and ocular pulse amplitude with accommodation

Read, S. A., Collins, M. J., Becker, H., Cutting, J., Ross, D., Savill, A., & Trevor, B. (2009) · British Journal of Ophthalmology · doi:10.1136/bjo.2009.166355 · Cited by 64

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma

Mathieu, E., Gupta, N., Paczka-Giorgi, L. A., Zhou, X., Ahari, A., Lani‐Louzada, R., Hanna, J., & Yücel, Y. H. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24521 · Cited by 60

Assessment of the dynamics of human glymphatic system by near‐infrared spectroscopy

Myllylä, T., Harju, M., Korhonen, V. O., Bykov, A. V., Kiviniemi, V. J., & Meglinski, I. V. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700123 · Cited by 59

Age-related posterior ciliary muscle restriction – A link between trabecular meshwork and optic nerve head pathophysiology

Croft, M. A., Lütjen-Drecoll, E., & Kaufman, P. L. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.07.007 · Cited by 55

Real-Time Monitoring of Suprachoroidal Space (SCS) Following SCS Injection Using Ultra-High Resolution Optical Coherence Tomography in Guinea Pig Eyes

Bing, G., Liu, J., Li, X., Ma, Q., Shen, M., & Cheng, L. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16597 · Cited by 49

Elevated intracranial pressure causes optic nerve and retinal ganglion cell degeneration in mice

Nusbaum, D. M., Wu, S. M.-S., & Frankfort, B. J. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.04.014 · Cited by 45

Retinal glymphatic system: an explanation for transient retinal layer volume changes?

Petzold, A. (2016) · Brain · doi:10.1093/brain/aww239 · Cited by 45

Chronic Ocular Hypertension Induced by Circumlimbal Suture in Rats

Liu, H., Bui, B. V., Nguyen, C. T. O., Kezic, J. M., Vingrys, A. J., & He, Z. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16009 · Cited by 44

Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles

Yücel, Y. H., Cardinell, K., Khattak, S., Zhou, X., Lapinski, M., Cheng, F., & Gupta, N. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22850 · Cited by 43

Reduced Expression of Aquaporin-9 in Rat Optic Nerve Head and Retina following Elevated Intraocular Pressure

Naka, M., Kanamori, A., Negi, A., & Nakamura, M. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4712 · Cited by 40

Induction of amyloid-β(1-42) in the retina and optic nerve head of chronic ocular hypertensive monkeys.

Ito, Y., Shimazawa, M., Tsuruma, K., Mayama, C., Ishii, K., Onoe, H., Aihara, M., Araie, M., & Hara, H. (2012) · Europe PMC (PubMed Central) · Cited by 39

The pathway of subarachnoid CSF moving into the spinal parenchyma and the role of astrocytic aquaporin-4 in this process

Wei, F., Zhang, C., Xue, R., Shan, L., Gong, S., Wang, G., Tao, J., Xu, G., Zhang, G., & Wang, L. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.05.028 · Cited by 35

APP upregulation contributes to retinal ganglion cell degeneration via JNK3

Liu, C., Zhang, C.-W., Zhou, Y., Wong, W. Q., Lee, L. C., Ong, W., Yoon, S. O., Hong, W., Fu, X.-Y., Soong, T. W., et al. (2017) · Cell Death and Differentiation · doi:10.1038/s41418-017-0005-3 · Cited by 34

The “Ocular Glymphatic System”: An Important Missing Piece in the Puzzle of Optic Disc Edema in Astronauts?

Wostyn, P., & Deyn, P. P. D. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-23263 · Cited by 34

Effects of Static Accommodation Versus Repeated Accommodation on Intraocular Pressure

Jenssen, F., & Krohn, J. (2010) · Journal of Glaucoma · doi:10.1097/ijg.0b013e31820277a9 · Cited by 27

Distinct effects of inflammation on gliosis, osmohomeostasis, and vascular integrity during amyloid beta‐induced retinal degeneration

Dinet, V., Bruban, J., Chalour, N., Maoui, A., An, N., Jonet, L., Buret, A., Béhar‐Cohen, F., Klein, C., Tréton, J., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00834.x · Cited by 26

Characterizing the glymphatic influx by utilizing intracisternal infusion of fluorescently conjugated cadaverine

Zhang, C., Lin, J., Wei, F., Song, J. H., Chen, W., Shan, L., Xue, R., Wang, G., Tao, J., Zhang, G., et al. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.03.057 · Cited by 24

Dilated Prelaminar Paravascular Spaces as a Possible Mechanism for Optic Disc Edema in Astronauts

Wostyn, P., Winne, F. D., Stern, C., & Deyn, P. P. D. (2018) · Aerospace Medicine and Human Performance · doi:10.3357/amhp.5095.2018 · Cited by 24

Intravital Imaging Reveals Dynamics of Lymphangiogenesis and Valvulogenesis

Kang, G. J., Ecoiffier, T., Truong, T. N., Yuen, D., Li, G., Lee, N., Zhang, L., & Chen, L. (2016) · Scientific Reports · doi:10.1038/srep19459 · Cited by 22

Comparison of laser and circumlimbal suture induced elevation of intraocular pressure in albino CD-1 mice

Liu, H., Zhang, L., Shi, M., Chen, L., & Flanagan, J. G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189094 · Cited by 20

Cannulation of the internal carotid artery in mice: A novel technique for intra-arterial delivery of therapeutics

Santillán, A., Rubin, D. G., Foley, C. P., Sondhi, D., Crystal, R. G., Gobin, Y. P., & Ballon, D. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.11.008 · Cited by 17

Intracranial pressure and glaucoma: Is there a new therapeutic perspective on the horizon?

Wostyn, P., Dam, D. V., & Deyn, P. P. D. (2018) · Medical Hypotheses · doi:10.1016/j.mehy.2018.06.026 · Cited by 16

Time- and dose-related effects of amyloid beta1-40 on retina and optic nerve morphology in rats

Lazaldin, M. A. M., Iezhitsa, I. N., Agarwal, R., Bakar, N. S., Agarwal, P., & Ismail, N. M. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1446953 · Cited by 11

The Value of Mouse Models for Glaucoma Drug Discovery

Dismuke, W. M., Overby, D. R., Civan, M. M., & Stamer, W. D. (2016) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2016.29010.mjc · Cited by 10

Iris Transillumination Defects in Patients with Primary Open Angle Glaucoma

Christen, R., Pache, M., Teuchner, B., Meyer, P., Prünte, C. F., & Flammer, J. (2003) · European Journal of Ophthalmology · doi:10.1177/112067210301300406 · Cited by 7

Mouse Retinal Whole Mounts and Quantification of Vasculature Protocol

Adini, I., & Ghosh, K. (2015) · BIO-PROTOCOL · doi:10.21769/bioprotoc.1546 · Cited by 6

Glymphatic failure as a final common pathway to dementia

Nedergaard, M., & Goldman, S. A. (2020) · Science · doi:10.1126/science.abb8739 · Cited by 1,145

Fluid transport in the brain

Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 642

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