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The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
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Abstract
Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.
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“Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral reand deactivation and organ homing are interconnected for different body compartments. 13,14,44,45”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [45]
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Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
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Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
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Self-citationHIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
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Research works printed but not linked: 1
- W. R. McManus, M. J. Bale, J. Spindler, A. Wiegand, A. Musick, S. C. Patro, M. D. Sobolewski, V. K. Musick, E. M. Anderson, J. C. Cyktor, E. K. Halvas, W. Shao, D. Wells, X. Wu, B. F. Keele, J. M. Milush, R. Hoh, J. W. Mellors, S. H. Hughes, S. G. Deeks, J. M. Coffin, M. F. Kearney, HIV-1in lymph nodes is maintained by cellular proliferation during antiretroviral therapy. J. Clin. Invest. 130, 126714 (2019).
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Self-citationSystemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo
Nixon, C. C., Mavigner, M., Sampey, G. C., Brooks, A. D., Spagnuolo, R. A., Irlbeck, D. M., Mattingly, C., Ho, P. T., Schoof, N., Cammon, C. G., et al. (2020) · Nature · doi:10.1038/s41586-020-1951-3 · Cited by 308
Self-citationThe Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies
Cohn, L. B., Chomont, N., & Deeks, S. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.014 · Cited by 296
Bekker, L., Beyrer, C., Mgodi, N. M., Lewin, S. R., Delany‐Moretlwe, S., Taiwo, B., Masters, M. C., & Lazarus, J. V. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00452-3 · Cited by 289
Curing HIV: Seeking to Target and Clear Persistent Infection
Margolis, D. M., Archin, N. M., Cohen, M. S., Eron, J. J., Ferrari, G., García, J. V., Gay, C. L., Goonetilleke, N. P., Joseph, S., Swanstrom, R. I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.005 · Cited by 179
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Metadata
- Authors
- Abrahams, M.-R., Joseph, S. B., Garrett, N., Tyers, L., Moeser, M., Archin, N., Council, O. D., Matten, D., Zhou, S., Doolabh, D., Anthony, C., Goonetilleke, N., Karim, S. A., Margolis, D. M., Pond, S. K., Williamson, C., & Swanstrom, R.
- Affiliations
- University of Cape Town (ZA)
- University of North Carolina at Chapel Hill (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
- Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
- National Health Laboratory Service (ZA)
- Corresponding author
- Williamson, Carolyn
- Swanstrom, Ronald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-10-09
- Volume
- 11
- Issue
- 513
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7233356
- OpenAlex
- W2980286610
- Cited by
- 196
- References
- 62
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 26 · 2023: 31 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 4
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NIH/MRC (R01 AI115981)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HIV-1 latent reservoir, antiretroviral therapy, viral quasispecies, women living with HIV
- MeSH terms
- Female, Humans, Phylogeny, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Viral Load, Anti-Retroviral Agents
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