The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
Open accessPublished version of a preprint
Abstract
Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral reand deactivation and organ homing are interconnected for different body compartments. 13,14,44,45”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [45]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
Katoh, K., & Standley, D. M. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst010 · Cited by 46,209
MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662
FastTree: Computing Large Minimum Evolution Trees with Profiles instead of a Distance Matrix
Price, M. N., Dehal, P. S., & Arkin, A. P. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp077 · Cited by 5,602
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
Finzi, D., Hermankova, M., Pierson, T., Carruth, L. M., Buck, C., Chaisson, R. E., Quinn, T. C., Chadwick, K., Margolick, J., Brookmeyer, R., et al. (1997) · Science · doi:10.1126/science.278.5341.1295 · Cited by 3,098
ETE 3: Reconstruction, Analysis, and Visualization of Phylogenomic Data
Huerta‐Cepas, J., Serra, F., & Bork, P. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw046 · Cited by 2,255
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
Wong, J. K., Hezareh, M., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Spina, C. A., & Richman, D. D. (1997) · Science · doi:10.1126/science.278.5341.1291 · Cited by 2,186
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
Chun, T.-W., Carruth, L., Finzi, D., Shen, X., DiGiuseppe, J. A., Taylor, H., Hermankova, M., Chadwick, K., Margolick, J., Quinn, T. C., et al. (1997) · Nature · doi:10.1038/387183a0 · Cited by 2,050
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
Chun, T., Stuyver, L. J., Mizell, S. B., Ehler, L. A., Mican, J. A. M., Baseler, M., Lloyd, A. L., Nowak, M. A., & Fauci, A. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13193 · Cited by 1,960
Keele, B. F., Giorgi, E. E., Salazar-Gonzalez, J. F., Decker, J. M., Pham, K. T., Salazar, M. G., Sun, C., Grayson, T. B., Wang, S., Li, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802203105 · Cited by 1,913
Self-citationHIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Chomont, N., Far, M. E., Ancuța, P., Trautmann, L., Procopio, F. A., Yassine‐Diab, B., Boucher, G., Boulassel, M., Ghattas, G., Brenchley, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1972 · Cited by 1,775
Siliciano, J. D., Kajdas, J., Finzi, D., Quinn, T. C., Chadwick, K., Margolick, J. B., Kovacs, C., Gange, S. J., & Siliciano, R. F. (2003) · Nature Medicine · doi:10.1038/nm880 · Cited by 1,703
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure
Ho, Y.-C., Shan, L., Hosmane, N. N., Wang, J., Laskey, S. B., Rosenbloom, D. I. S., Lai, J., Blankson, J. N., Siliciano, J. D., & Siliciano, R. F. (2013) · Cell · doi:10.1016/j.cell.2013.09.020 · Cited by 1,405
HIV preferentially infects HIV-specific CD4+ T cells
Douek, D. C., Brenchley, J. M., Betts, M. R., Ambrozak, D. R., Hill, B. J., Okamoto, Y., Casazza, J. P., Kuruppu, J. C., Kunstman, K., Wolinsky, S. M., et al. (2002) · Nature · doi:10.1038/417095a · Cited by 1,261
Matsen, F. A., IV, Kodner, R. B., & Armbrust, E. V. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-538 · Cited by 1,058
Shankarappa, R., Margolick, J. B., Gange, S. J., Rodrigo, A. G., Upchurch, D., Farzadegan, H., Gupta, P., Rinaldo, C. R., Learn, G. H., He, X., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.10489-10502.1999 · Cited by 926
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
Maldarelli, F., Wu, X., Su, L., Simonetti, F. R., Shao, W., Hill, S., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., et al. (2014) · Science · doi:10.1126/science.1254194 · Cited by 849
Defective proviruses rapidly accumulate during acute HIV-1 infection
Bruner, K. M., Murray, A. J., Pollack, R. A., Soliman, M. G., Laskey, S. B., Capoferri, A. A., Lai, J., Strain, M. C., Lada, S. M., Hoh, R., et al. (2016) · Nature Medicine · doi:10.1038/nm.4156 · Cited by 737
Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
Wagner, T. A., McLaughlin, S., Garg, K., Cheung, C. Y. K., Larsen, B. B., Styrchak, S., Huang, H. C., Edlefsen, P. T., Mullins, J. I., & Frenkel, L. M. (2014) · Science · doi:10.1126/science.1256304 · Cited by 677
Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys
Whitney, J. B., Hill, A. L., Sanisetty, S., Penaloza‐MacMaster, P., Liu, J., Shetty, M., Parenteau, L. R., Cabral, C., Shields, J. L., Blackmore, S., et al. (2014) · Nature · doi:10.1038/nature13594 · Cited by 648
Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells
Kondrack, R. M., Harbertson, J., Tan, J. T., McBreen, M. E., Surh, C. D., & Bradley, L. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030735 · Cited by 470
HIV-1 Integration Landscape during Latent and Active Infection
Cohn, L. B., da Silva, I. T., Oliveira, T. Y., Rosales, R., Parrish, E. H., Learn, G. H., Hahn, B. H., Czartoski, J., McElrath, M. J., Lehmann, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.020 · Cited by 460
Folks, T. M., Powell, D., Lightfoote, M. M., Koenig, S., Fauci, A. S., Benn, S., Rabson, A. B., Daugherty, D. F., Gendelman, H. E., & HOGGAN, M. D. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.1.280 · Cited by 416
Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies
Crooks, A. M., Bateson, R., Cope, A. B., Dahl, N., Griggs, M. K., Kuruc, J. D., Gay, C. L., Eron, J. J., Margolis, D. M., Bosch, R. J., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv218 · Cited by 415
Self-citationHosmane, N. N., Kwon, K. J., Bruner, K. M., Capoferri, A. A., Beg, S. A., Rosenbloom, D. I. S., Keele, B. F., Ho, Y., Siliciano, J. D., & Siliciano, R. F. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170193 · Cited by 386
Abrahams, M.-R., Anderson, J. A., Giorgi, E. E., Seoighe, C., Mlisana, K. P., Li, P., Athreya, G. S., Treurnicht, F. K., Keele, B. F., Wood, N. T., et al. (2009) · Journal of Virology · doi:10.1128/jvi.02132-08 · Cited by 378
Self-citationClonally expanded CD4 + T cells can produce infectious HIV-1 in vivo
Simonetti, F. R., Sobolewski, M. D., Fyne, E., Shao, W., Spindler, J., Hattori, J., Anderson, E. M., Watters, S. A., Hill, S., Wu, X., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522675113 · Cited by 372
Hiener, B., Horsburgh, B. A., Eden, J.-S., Barton, K., Schlub, T. E., Lee, E., von Stockenstrom, S., Odevall, L., Milush, J. M., Liegler, T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.081 · Cited by 370
Pollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S.-H., Karandish, S., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.008 · Cited by 370
Increased Turnover of T Lymphocytes in HIV-1 Infection and Its Reduction by Antiretroviral Therapy
Mohri, H., Perelson, A. S., Tung, K. S., Ribeiro, R. M., Ramratnam, B., Markowitz, M. H., Kost, R. G., Hurley, Weinberger, L. S., Cesar, D., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1277 · Cited by 359
Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID
Jabara, C. B., Jones, C. D., Roach, J. M., Anderson, J. A., & Swanstrom, R. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110064108 · Cited by 357
Self-citationFrost, S. D. W., Wrin, T., Smith, D. M., Pond, S. L. K., Liu, Y., Paxinos, E. E., Chappey, C., Galovich, J., Beauchaine, J., Petropoulos, C. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504658102 · Cited by 351
Self-citationImamichi, H., Dewar, R. L., Adelsberger, J. W., Rehm, C. A., O’Doherty, U., Paxinos, E. E., Fauci, A. S., & Lane, H. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609057113 · Cited by 344
The RV411 study group, Colby, D. J., Trautmann, L., Pinyakorn, S., Leyre, L., Pagliuzza, A., Kroon, E. D. M. B., Rolland, M., Takata, H., Buranapraditkun, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0026-6 · Cited by 331
Maldarelli, F. M., Wu, X., Su, L., Simonetti, F. R., Wells, D. W., Shao, W., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., et al. (2016) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000479721.09749.2d · Cited by 294
Buzón, M. J., Martín‐Gayo, E., Pereyra, F., Ouyang, Z., Sun, H., Li, J. Z., Piovoso, M. J., Shaw, A., Dalmau, J., Zangger, N., et al. (2014) · Journal of Virology · doi:10.1128/jvi.01046-14 · Cited by 277
Interleukin-7 promotes HIV persistence during antiretroviral therapy
Vandergeeten, C., Fromentin, R., DaFonseca, S., Lawani, M. B., Sereti, I., Lederman, M. M., Ramgopal, M. N., Routy, J., Sékaly, R., & Chomont, N. (2013) · Blood · doi:10.1182/blood-2012-11-465625 · Cited by 249
Bui, J. K., Sobolewski, M. D., Keele, B. F., Spindler, J., Musick, A., Wiegand, A. P., Luke, B. T., Shao, W., Hughes, S. H., Coffin, J. M., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006283 · Cited by 243
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
Hellerstein, M. K., Hoh, R., Hanley, M. B., Cesar, D., Lee, D. C., Neese, R. A., & McCune, J. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317533 · Cited by 243
Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals
Paiardini, M., Cervasi, B., Albrecht, H., Muthukumar, A., Dunham, R. M., Gordon, S. N., Radziewicz, H., Piedimonte, G., Magnani, M., Montroni, M., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2900 · Cited by 233
Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane
Wang, Z., Gurule, E., Brennan, T. P., Gerold, J. M., Kwon, K. J., Hosmane, N. N., Kumar, M. R., Beg, S. A., Capoferri, A. A., Ray, S. C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720665115 · Cited by 225
Henrich, T. J., Hatano, H., Bacon, O., Hogan, L. E., Rutishauser, R. L., Hill, A. L., Kearney, M. F., Anderson, E. M., Buchbinder, S., Cohen, S. E., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002417 · Cited by 224
High-level HIV-1 viremia suppresses viral antigen-specific CD4 + T cell proliferation
McNeil, A. C., Shupert, W. L., Iyasere, C. A., Hallahan, C. W., Mican, J. M., Davey, R. T., & Connors, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251539598 · Cited by 211
van Loggerenberg, F., Mlisana, K. P., Williamson, C. E., Auld, S. C., Morris, L., Gray, C. M., Karim, Q. A., Grobler, A. C., Barnabas, N., Iriogbe, I., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001954 · Cited by 206
Self-citationPond, S. L. K., Posada, D., Stawiski, E. W., Chappey, C., Poon, A. F. Y., Hughes, G., Fearnhill, E., Gravenor, M. B., Brown, A., & Frost, S. D. W. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000581 · Cited by 198
Self-citationMultiple Origins of Virus Persistence during Natural Control of HIV Infection
Boritz, E., Darko, S. W., Swaszek, L., Wolf, G. S., Wells, D. W., Wu, X., Henry, A. R., Laboune, F., Hu, J., Ambrozak, D. R., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.039 · Cited by 186
Shan, L., Deng, K., Gao, H., Xing, S., Capoferri, A. A., Durand, C. M., Rabi, S. A., Laird, G. M., Kim, M., Hosmane, N. N., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.014 · Cited by 185
Species-Level Analysis of DNA Sequence Data from the NIH Human Microbiome Project
Conlan, S., Kong, H. H., & Segre, J. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047075 · Cited by 182
Pinzone, M. R., VanBelzen, J., Weissman, S., Bertuccio, M. P., Cannon, L., Rullo, E. V., Migueles, S. A., Jones, R. B., Mota, T. M., Joseph, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08431-7 · Cited by 179
Self-citationHLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
Brumme, Z. L., John, M., Carlson, J. M., Brumme, C. J., Chan, D., Brockman, M. A., Swenson, L. C., Tao, I., Szeto, S., Rosato, P. C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006687 · Cited by 163
Quantitation of Replication-Competent HIV-1 in Populations of Resting CD4 + T Cells
Soriano-Sarabia, N., Bateson, R., Dahl, N., Crooks, A. M., Kuruc, J. D., Margolis, D. M., & Archin, N. M. (2014) · Journal of Virology · doi:10.1128/jvi.01900-14 · Cited by 162
Self-citationEstablishment and stability of the latent HIV-1 DNA reservoir
Brodin, J., Zanini, F., Thebo, L., Lanz, C., Bratt, G., Neher, R. A., & Albert, J. (2016) · eLife · doi:10.7554/elife.18889 · Cited by 157
Evering, T. H., Mehandru, S., Rácz, P., Tenner‐Racz, K., Poles, M. A., Figueroa, A., Mohri, H., & Markowitz, M. H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002506 · Cited by 127
Zhou, S., Jones, C. D., Mieczkowski, P. A., & Swanstrom, R. I. (2015) · Journal of Virology · doi:10.1128/jvi.00522-15 · Cited by 124
Self-citationDunham, R. M., Cervasi, B., Brenchley, J. M., Albrecht, H., Weintrob, A., Sumpter, B., Engram, J. C., Gordon, S. N., Klatt, N. R., Frank, I., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5582 · Cited by 121
Koesters, S. A., Alimonti, J. B., Wachihi, C., Matu, L., Anzala, O. A., Kimani, J., Embree, J. E., Plummer, F. A., & Fowke, K. R. (2006) · European Journal of Immunology · doi:10.1002/eji.200535111 · Cited by 96
Scriba, T. J., Tameris, M. D., Smit, E., van der Merwe, L., Hughes, E. J., Kadira, B., Mauff, K. A. L., Moyo, S., Brittain, N. J., Lawrie, A. M., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201108-1548oc · Cited by 84
No evidence of HIV replication in children on antiretroviral therapy
van Zyl, G. U., Katusiime, M. G., Wiegand, A. P., McManus, W. R., Bale, M. J., Halvas, E. K., Luke, B. T., Boltz, V. F., Spindler, J., Laughton, B., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94582 · Cited by 78
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
Jones, B. R., Kinloch, N. N., Horacsek, J., Ganase, B., Harris, M., Harrigan, P. R., Jones, R. B., Brockman, M. A., Joy, J. B., Poon, A. F. Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802028115 · Cited by 55
Loss of CD127 expression links immune activation and CD4+ T cell loss in HIV infection
Kiazyk, S. A. K., & Fowke, K. R. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.08.011 · Cited by 49
Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure
Goonetilleke, N. P., Clutton, G., Swanstrom, R., & Joseph, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01966 · Cited by 27
Self-citationAssigning and visualizing germline genes in antibody repertoires
Frost, S. D. W., Murrell, B., Hossain, A., Silverman, G. J., & Pond, S. L. K. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0240 · Cited by 22
Self-citationCD127 Expression in Naive and Memory T Cells in HIV Patients Who Have Undergone Long-Term HAART
Xu, W., Li, J., Wu, Y., Zhou, J., Zhong, J., Lv, Q., Shao, H., & Rao, H. (2016) · Laboratory Medicine · doi:10.1093/labmed/lmw053 · Cited by 17
Flagged first, then by citations
Research works printed but not linked: 1
- W. R. McManus, M. J. Bale, J. Spindler, A. Wiegand, A. Musick, S. C. Patro, M. D. Sobolewski, V. K. Musick, E. M. Anderson, J. C. Cyktor, E. K. Halvas, W. Shao, D. Wells, X. Wu, B. F. Keele, J. M. Milush, R. Hoh, J. W. Mellors, S. H. Hughes, S. G. Deeks, J. M. Coffin, M. F. Kearney, HIV-1in lymph nodes is maintained by cellular proliferation during antiretroviral therapy. J. Clin. Invest. 130, 126714 (2019).
Cited by
Sorted by citations
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Deeks, S. G., Archin, N., Cannon, P., Collins, S., Jones, R. B., de Jong, M. A. W. P., Lambotte, O., Lamplough, R., Ndung’u, T., Sugarman, J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01590-5 · Cited by 377
Self-citationSystemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo
Nixon, C. C., Mavigner, M., Sampey, G. C., Brooks, A. D., Spagnuolo, R. A., Irlbeck, D. M., Mattingly, C., Ho, P. T., Schoof, N., Cammon, C. G., et al. (2020) · Nature · doi:10.1038/s41586-020-1951-3 · Cited by 308
Self-citationThe Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies
Cohn, L. B., Chomont, N., & Deeks, S. G. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.014 · Cited by 296
Bekker, L., Beyrer, C., Mgodi, N. M., Lewin, S. R., Delany‐Moretlwe, S., Taiwo, B., Masters, M. C., & Lazarus, J. V. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00452-3 · Cited by 289
Curing HIV: Seeking to Target and Clear Persistent Infection
Margolis, D. M., Archin, N. M., Cohen, M. S., Eron, J. J., Ferrari, G., García, J. V., Gay, C. L., Goonetilleke, N. P., Joseph, S., Swanstrom, R. I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.005 · Cited by 179
Self-citation
Metadata
- Authors
- Abrahams, M.-R., Joseph, S. B., Garrett, N., Tyers, L., Moeser, M., Archin, N., Council, O. D., Matten, D., Zhou, S., Doolabh, D., Anthony, C., Goonetilleke, N., Karim, S. A., Margolis, D. M., Pond, S. K., Williamson, C., & Swanstrom, R.
- Affiliations
- University of Cape Town (ZA)
- University of North Carolina at Chapel Hill (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
- Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
- National Health Laboratory Service (ZA)
- Corresponding author
- Williamson, Carolyn
- Swanstrom, Ronald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-10-09
- Volume
- 11
- Issue
- 513
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7233356
- OpenAlex
- W2980286610
- Cited by
- 196
- References
- 62
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 26 · 2023: 31 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 4
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NIH/MRC (R01 AI115981)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HIV-1 latent reservoir, antiretroviral therapy, viral quasispecies, women living with HIV
- MeSH terms
- Female, Humans, Phylogeny, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Viral Load, Anti-Retroviral Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
