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The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
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Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.
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“Studies have suggested a close genetic relatedness of recovered viruses, suggesting that viral reand deactivation and organ homing are interconnected for different body compartments. 13,14,44,45”
From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [45]
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Metadata
- Authors
- Abrahams, M.-R., Joseph, S. B., Garrett, N., Tyers, L., Moeser, M., Archin, N., Council, O. D., Matten, D., Zhou, S., Doolabh, D., Anthony, C., Goonetilleke, N., Karim, S. A., Margolis, D. M., Pond, S. K., Williamson, C., & Swanstrom, R.
- Affiliations
- University of Cape Town (ZA)
- University of North Carolina at Chapel Hill (US)
- Centre for the AIDS Programme of Research in South Africa (ZA)
- Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
- Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
- Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
- National Health Laboratory Service (ZA)
- Corresponding author
- Williamson, Carolyn
- Swanstrom, Ronald
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2019-10-09
- Volume
- 11
- Issue
- 513
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7233356
- OpenAlex
- W2980286610
- Cited by
- 196
- References
- 62
- Citations by year
- 2026: 13 · 2025: 25 · 2024: 26 · 2023: 31 · 2022: 33 · 2021: 28 · 2020: 36 · 2019: 4
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science Translational Medicine (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NIH/MRC (R01 AI115981)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HIV-1 latent reservoir, antiretroviral therapy, viral quasispecies, women living with HIV
- MeSH terms
- Female, Humans, Phylogeny, Virus Replication, CD4-Positive T-Lymphocytes, HIV-1, HIV Infections, Virus Latency, Viral Load, Anti-Retroviral Agents
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