The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
Open accessAbstract
Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption.
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“Only the deletion of both MMP9 and MMP14 generated a reduction in bone resorption areas and in type I collagenolysis activity.153”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [153]
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Cites
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Osteoclast differentiation and activation
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“In addition, alkaline shifts have been predicted to occur within the osteoclast-bone matrix interface during the demineralization process (3).”
BackgroundMacrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684 · cited 1×
“Although Csf1r-Cre expression extends beyond osteoclasts to include a number of myeloid cell–derived cell populations (30, 65, 66), each of the defects we”
BackgroundRemodelling the extracellular matrix in development and disease
Bonnans, C., Chou, J., & Werb, Z. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3904 · Cited by 4,367 · cited 8×
“Coincident with this process, osteoclasts mobilize proteinases whose functions are most commonly linked to the degradation of triple-helical type I collagen, the dominant extracellular matrix (ECM) component found in the bone (1).”
BackgroundMethodInfluentialOsteoporosis: now and the future
Rachner, T. D., Khosla, S., & Hofbauer, L. C. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62349-5 · Cited by 2,696
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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems
Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878
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Genetic regulation of osteoclast development and function
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Cited by
Sorted by citations
Osteoblast-Osteoclast Communication and Bone Homeostasis
Kim, J., Lin, C., Stavre, Z., Greenblatt, M. B., & Shim, J. (2020) · Cells · doi:10.3390/cells9092073 · Cited by 1,266
A guide to the composition and functions of the extracellular matrix
Karamanos, N. K., Theocharis, A. D., Piperigkou, Z., Manou, D., Passi, A. G., Skandalis, S. S., Vynios, D. H., Orian‐Rousseau, V., Ricard‐Blum, S., Schmelzer, C. E. H., et al. (2021) · FEBS Journal · doi:10.1111/febs.15776 · Cited by 1,177
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 546
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
“Only the deletion of both MMP9 and MMP14 generated a reduction in bone resorption areas and in type I collagenolysis activity.(153) The fusion of the earliest osteoclast precursors into multinucleated, mature osteoclasts is a critical process in osteoclastogenesis, as the number of nuclei per cell determines osteoclas…”
BackgroundOsteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration
Zhang, J. C., Tong, D., Song, H., Ruan, R., Sun, Y., Lin, Y., Wang, J., Hou, L., Dai, J., Ding, J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202202044 · Cited by 350
Metadata
- Authors
- Zhu, L., Tang, Y., Li, X.-Y., Keller, E. T., Yang, J., Cho, J.-S., Feinberg, T. Y., & Weiss, S. J.
- Affiliations
- University of Michigan (US)
- Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
- Corresponding author
- Zhu, Lingxin
- Weiss, Stephen J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-02-05
- Volume
- 12
- Issue
- 529
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7603424
- OpenAlex
- W3005525925
- Cited by
- 178
- References
- 89
- Citations by year
- 2026: 30 · 2025: 31 · 2024: 34 · 2023: 25 · 2022: 24 · 2021: 18 · 2020: 15
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AI105068, CA093900, CA071699, AR075168)
- Breast Cancer Research Foundation
- National Natural Science Foundation of China (81970919)
- Margolies Family Discovery Fund for Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclasts, bone resorption, metalloproteinases, MMP-9, MMP-14, collagen degradation, bone mineral density, parathyroid hormone, ovariectomy, bone loss, therapeutic target
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Cathepsins, Female, Humans, Osteoclasts, Osteoporosis, Ovariectomy, Mice
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