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Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
Open accessAbstract
Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption.
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“Only the deletion of both MMP9 and MMP14 generated a reduction in bone resorption areas and in type I collagenolysis activity.153”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [153]
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BackgroundMT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling
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“To assess the magnitude of Ctsk-independent collagenolytic activity, we cultured wild-type, Mmp9−/−, Mmp14M/M, or DKO osteoclasts atop decalcified bone slices to directly monitor bone collagen degradation independently of acidification/demineralization (37) and monitored collagen degradation by the release of the cr…”
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Mouse Cre Models for the Study of Bone Diseases
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“Given the morbidity and mortality displayed by Mmp14 global null mice (28, 29), Mmp14M/M crosses were generated to target the proteinase in myeloid progenitors, including the osteoclast-derived lineage (30).”
BackgroundFeinberg, T. Y., Zheng, H., Liu, R., Wicha, M. S., Yu, S. M., & Weiss, S. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.08.025 · Cited by 78
Self-citationCathepsin K Controls Cortical Bone Formation by Degrading Periostin
Bonnet, N., Brun, J., Rousseau, J., Duong, L. T., & Ferrari, S. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3136 · Cited by 77
Bolton, C. E., Stone, M., Edwards, P. H., Duckers, J. M., Evans, W. D., & Shale, D. (2009) · Chronic Respiratory Disease · doi:10.1177/1479972309103131 · Cited by 72
PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation
Zhang, Y., Rohatgi, N., Novack, D. V., Schilling, J. D., Teitelbaum, S. L., & Zou, W. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3398 · Cited by 72 · cited 1×
“S7C), a finding similar to the phenotype observed by myeloid-specific deletion of proliferator-activated receptor coactivator 1 or miR-182 (49, 50).”
ResultBrömme, D., Panwar, P., & Turan, S. (2016) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2016.1160884 · Cited by 64
Nishida, C., Kusubata, K., Tashiro, Y., Gritli, I., Sato, A., Ohki, M., Morita, Y., Nagano, M., Sakamoto, T., Koshikawa, N., et al. (2012) · Blood · doi:10.1182/blood-2011-11-390849 · Cited by 56 · cited 1×
“Mmp14 also exerts profound effects on the bone marrow environment itself by controlling skeletal stem cell function, raising the possibility that bone marrow– derived myeloid cells recovered from global knockout mice might be affected in a noncell autonomous fashion (21, 62, 64).”
BackgroundMutations of CTSK Result in Pycnodysostosis via a Reduction in Cathepsin K Protein
Ho, N. C., Punturieri, A., Wilkin, D. J., Szabo, J., Johnson, M. R., Whaley, J., Davis, J., Clark, A. D., Weiss, S. J., & Francomano, C. A. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.10.1649 · Cited by 55 · cited 1×
“DISCUSSION More than 20 years ago, the importance of CTSK in regulating human osteoclast activity was confirmed with its identification as the mutant gene responsible for pycnodysostosis, a hereditary bone disorder characterized by major defects in bone resorption (11, 12, 55, 56).”
BackgroundSelf-citationSakamoto, T., & Seiki, M. (2017) · Cancer Science · doi:10.1111/cas.13231 · Cited by 51
MT1‐MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B‐cell development
Jin, G., Zhang, F., Chan, K. M., Xavier Wong, H. L., Liu, B., Cheah, K. S. E., Liu, X., Mauch, C., Liu, D., & Zhou, Z. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.136 · Cited by 50
Inhibition of osteoclast formation and function by bicarbonate: Role of soluble adenylyl cyclase
Geng, W., Hill, K., Zerwekh, J. E., Kohler, T., Müller, R., & Moe, O. W. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21767 · Cited by 49
PPARγ Regulates Pharmacological but not Physiological nor Pathological Osteoclast Formation
Zou, W., Rohatgi, N., Chen, T. H., Schilling, J., Abu-Amer, Y., & Teitelbaum, S. (2016) · Nature Medicine · doi:10.1038/nm.4208 · Cited by 32 · cited 3×
“By contrast, OVX induces bone loss secondary to the loss of estrogen that normally occurs in the postmenopausal state (5, 6, 19).”
BackgroundTherapeutic implications of suppressing osteoclast formation versus function
Teitelbaum, S. L. (2016) · Rheumatology · doi:10.1093/rheumatology/kew350 · Cited by 25
Okaji, M., Sakai, H., Sakai, E., Shibata, M., Hashimoto, F., Kobayashi, Y., Yoshida, N., Okamoto, K., Yamamoto, K., & Kato, Y. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.285 · Cited by 23
Srivastava, A. K., Bhattacharyya, S. K., Castillo, G., Miyakoshi, N., Mohan, S., & Baylink, D. J. (2000) · Bone · doi:10.1016/s8756-3282(00)00356-2 · Cited by 18
Zhou, Q.-H., Huang, X., Wang, J., Lin, C., Yang, Y., Huang, C., Wu, L.-T., & Wu, Y.-M. (2012) · PubMed · doi:10.3760/cma.j.issn.1003-9406.2012.03.014 · Cited by 2 · cited 1×
“12 of 15 with human osteoporosis status (73, 74).”
Background
Cited by
Sorted by citations
Osteoblast-Osteoclast Communication and Bone Homeostasis
Kim, J., Lin, C., Stavre, Z., Greenblatt, M. B., & Shim, J. (2020) · Cells · doi:10.3390/cells9092073 · Cited by 1,266
A guide to the composition and functions of the extracellular matrix
Karamanos, N. K., Theocharis, A. D., Piperigkou, Z., Manou, D., Passi, A. G., Skandalis, S. S., Vynios, D. H., Orian‐Rousseau, V., Ricard‐Blum, S., Schmelzer, C. E. H., et al. (2021) · FEBS Journal · doi:10.1111/febs.15776 · Cited by 1,177
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 546
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
“Only the deletion of both MMP9 and MMP14 generated a reduction in bone resorption areas and in type I collagenolysis activity.(153) The fusion of the earliest osteoclast precursors into multinucleated, mature osteoclasts is a critical process in osteoclastogenesis, as the number of nuclei per cell determines osteoclas…”
BackgroundOsteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration
Zhang, J. C., Tong, D., Song, H., Ruan, R., Sun, Y., Lin, Y., Wang, J., Hou, L., Dai, J., Ding, J., et al. (2022) · Advanced Materials · doi:10.1002/adma.202202044 · Cited by 350
Metadata
- Authors
- Zhu, L., Tang, Y., Li, X.-Y., Keller, E. T., Yang, J., Cho, J.-S., Feinberg, T. Y., & Weiss, S. J.
- Affiliations
- University of Michigan (US)
- Division of Genetic Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
- Corresponding author
- Zhu, Lingxin
- Weiss, Stephen J.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-02-05
- Volume
- 12
- Issue
- 529
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC7603424
- OpenAlex
- W3005525925
- Cited by
- 178
- References
- 89
- Citations by year
- 2026: 30 · 2025: 31 · 2024: 34 · 2023: 25 · 2022: 24 · 2021: 18 · 2020: 15
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AI105068, CA093900, CA071699, AR075168)
- Breast Cancer Research Foundation
- National Natural Science Foundation of China (81970919)
- Margolies Family Discovery Fund for Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclasts, bone resorption, metalloproteinases, MMP-9, MMP-14, collagen degradation, bone mineral density, parathyroid hormone, ovariectomy, bone loss, therapeutic target
- MeSH terms
- Animals, Bone and Bones, Bone Resorption, Cathepsins, Female, Humans, Osteoclasts, Osteoporosis, Ovariectomy, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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