Lactation improves pancreatic β cell mass and function through serotonin production
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Lactation benefits women’s metabolic health by improving pancreatic β cell mass and function through serotonin production in β cells.
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These factors resulted in improved β-cell function at 4 years postpartum in Korean women with GDM who previously lactated compared to those who did not lactate (40% increase in disposition index).
“These factors resulted in improved β-cell function at 4 years postpartum in Korean women with GDM who previously lactated compared to those who did not lactate (40% increase in disposition index) [56].”
From Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications (2022) · cites this paper as [56]
The Results section reports a significantly higher disposition index in women who had lactated at the last follow-up, a mean of 3.6 years postpartum; Methods says participants were recruited in Korea. However, the cohort included women with either GDM or gestational impaired glucose tolerance, and our copy does not report the claimed 40% increase. (LLM, conf=0.86)
Experimental — accuracy not yet measuredModifiable risk factors including lactation, exercise, healthy diet, postpartum weight loss, and improving body composition correlate with improvement in insulin sensitivity.
“In addition to these nonmodifiable risk factors, clinicians should be aware of improving modifiable risk factors, including lactation, exercise, healthy diet, postpartum weight loss, and improving body composition [46,53-56], all of which correlate with improvement in insulin sensitivity.”
From Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications (2022) · cites this paper as [56]
Experimental — accuracy not yet measuredDuring lactation, β-cell mass expansion and insulin secretion are potentiated with increased circulating prolactin.
“During lactation, β-cell mass expansion and insulin secretion are potentiated with increased circulating prolactin [56].”
From Gestational Diabetes Mellitus: Diagnostic Approaches and Maternal-Offspring Complications (2022) · cites this paper as [56]
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- Authors
- Moon, J. H., Kim, H., Kim, H., Park, J., Choi, W., Choi, W., Hong, H. J., Ro, H.-J., Jun, S., Choi, S. H., Banerjee, R. R., Shong, M., Cho, N. H., Kim, S. K., German, M. S., Jang, H. C., & Kim, H.
- Affiliations
- Seoul National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
- Chungnam National University (KR)
- Korea Basic Science Institute (KR)
- University of Alabama (US)
- Ajou University (KR)
- Stanford Medicine (US)
- University of California, San Francisco (US)
- Corresponding author
- Moon, Joon Ho
- Kim, Hyeongseok
- German, Michael S.
- Jang, Hak Chul
- Kim, Hail
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2020-04-29
- Volume
- 12
- Issue
- 541
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8276761
- OpenAlex
- W3021541906
- Semantic Scholar
- 71348fdc43e64ddbc5b7b9be69308ec310526602
- Cited by
- 67
- References
- 67
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 18 · 2023: 11 · 2022: 14 · 2021: 7 · 2020: 1
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- KAIST Institutional Repository (KAIST) (submittedVersion)
- Funders
- National Institutes of Health (DK104211, P30 DK116074-01, Mentored Clinical Scientist Development Award K08, P30 DK063720)
- Larry L. Hillblom Foundation (2018-D-0006-NET)
- National Research Foundation of Korea (NRF-2017H1A2A1042095, NRF-2015M3A9B3028218, NRF-2018R1A2A3074646, NRF-2013H1A8A1003985, NRF-2018R1A6A3A01012333)
- National Research Council of Science and Technology (CRC-16-01-KRICT)
- Health Fellowship Foundation
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- lactation, pancreatic beta cells, serotonin, beta-cell mass, beta-cell proliferation, prolactin, insulin secretion, glucose tolerance, oxidative stress, beta-cell survival, postpartum diabetes, insulin resistance
- MeSH terms
- Animals, Blood Glucose, Breast Feeding, Female, Humans, Insulin, Lactation, Serotonin, Insulin-Secreting Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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