Enhancement of in vitro growth of pathogenic bacteria by norepinephrine: importance of inoculum density and role of transferrin
Open accessAbstract
Norepinephrine is a stress hormone that enhances bacterial growth. We examined the effects of a small inoculum on the norepinephrine-induced growth of species previously reported to be unaffected by norepinephrine. The results indicated that a reduced inoculum density is essential for observing norepinephrine-induced effects. Additional studies using serum-free media suggested that transferrin plays a role in norepinephrine-induced growth.
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Bacterial growth promotion by host stress molecules is not unique to P aeruginosa and is also seen with Streptococcus pneumoniae, S aureus, and Klebsiella pneumoniae.
“Bacterial growth promotion by host stress molecules is not unique to P aeruginosa, and is also seen with Streptococcus pneumoniae,121 S aureus,122 and Klebsiella pneumoniae.”
From The microbiome and critical illness (2016) · cites this paper as [122]
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- Authors
- O'Donnell, P. M., Aviles, H., Lyte, M., & Sonnenfeld, G.
- Affiliations
- Binghamton University (US)
- Department of Biological Sciences, Binghamton University, State University of New York, Binghamton, New York 13902
- Texas Tech University (US)
- ORCID
- Lyte, Mark
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2006-07
- Volume
- 72
- Issue
- 7
- Pages
- 5097-5099
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2086963814
- Cited by
- 99
- References
- 38
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NCC958)
- National Space Biomedical Research Institute (NCC 9‐58)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- norepinephrine, bacterial growth enhancement, pathogenic bacteria, inoculum size, transferrin, serum-free medium, stress hormones, iron acquisition
- MeSH terms
- Culture Media, Gram-Negative Bacteria, Humans, Norepinephrine, Staphylococcus aureus, Transferrin, Colony Count, Microbial
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