Cited by 209Biofuel production and bioconversionMicrobial Metabolic Engineering and BioproductionFungal and yeast genetics research

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Engineering of Saccharomyces cerevisiae for Efficient Anaerobic Alcoholic Fermentation of l -Arabinose

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Wisselink, H. Wouter, Toirkens, Maurice J., del Rosario Franco Berriel, M., Winkler, Aaron A., van Dijken, Johannes P., Pronk, Jack T., van Maris, Antonius J. A.·2007·Applied and Environmental Microbiology

DOI 10.1128/aem.00177-07PMC PMC1951023

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Abstract

For cost-effective and efficient ethanol production from lignocellulosic fractions of plant biomass, the conversion of not only major constituents, such as glucose and xylose, but also less predominant sugars, such as l -arabinose, is required. Wild-type strains of Saccharomyces cerevisiae , the organism used in industrial ethanol production, cannot ferment xylose and arabinose. Although metabolic and evolutionary engineering has enabled the efficient alcoholic fermentation of xylose under anaerobic conditions, the conversion of l -arabinose into ethanol by engineered S. cerevisiae strains has previously been demonstrated only under oxygen-limited conditions. This study reports the first case of fast and efficient anaerobic alcoholic fermentation of l -arabinose by an engineered S. cerevisiae strain. This fermentation was achieved by combining the expression of the structural genes for the l -arabinose utilization pathway of Lactobacillus plantarum , the overexpression of the S. cerevisiae genes encoding the enzymes of the nonoxidative pentose phosphate pathway, and extensive evolutionary engineering. The resulting S. cerevisiae strain exhibited high rates of arabinose consumption (0.70 g h −1 g [dry weight] −1 ) and ethanol production (0.29 g h −1 g [dry weight] −1 ) and a high ethanol yield (0.43 g g −1 ) during anaerobic growth on l -arabinose as the sole carbon source. In addition, efficient ethanol production from sugar mixtures containing glucose and arabinose, which is crucial for application in industrial ethanol production, was achieved.

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Authors: Wisselink, H. W., Toirkens, M. J., del Rosario Franco Berriel, M., Winkler, A. A., van Dijken, J. P., Pronk, J. T., & van Maris, A. J. A.
Affiliations: Delft University of Technology (NL)
Bird Engineering B.V., Westfrankelandsedijk 1, 3115 HG Schiedam, The Netherlands
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC Delft
ORCID: Pronk, Jack T.
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2007-08
Volume: 73
Issue: 15
Pages: 4881-4891
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.00177-07
PMC: PMC1951023
OpenAlex: W2139956564
Cited by: 209
References: 46
Citations by year: 2026: 3 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 6 · 2020: 11 · 2019: 12 · 2018: 13 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 16
FWCI: 12.19
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Research Repository (Delft University of Technology) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Ministerie van Economische Zaken
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics: Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Saccharomyces cerevisiae, ethanol production, evolutionary engineering, lignocellulosic biomass, xylose fermentation, heterologous expression
MeSH terms: Ethanol, Anaerobiosis, Arabinose, Fermentation, Genetic Engineering, Industrial Microbiology, Pentose Phosphate Pathway, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Lactiplantibacillus plantarum

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Engineering of Saccharomyces cerevisiae for Efficient Anaerobic Alcoholic Fermentation of l -Arabinose

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