Cited by 797Gut microbiota and healthProbiotics and Fermented FoodsMicrobial Fuel Cells and Bioremediation

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pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon

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Walker, Alan W., Duncan, Sylvia H., McWilliam Leitch, E. Carol, Child, Matthew W., Flint, Harry J.·2005·Applied and Environmental Microbiology

DOI 10.1128/aem.71.7.3692-3700.2005PMC PMC1169066

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Abstract

The effects of changes in the gut environment upon the human colonic microbiota are poorly understood. The response of human fecal microbial communities from two donors to alterations in pH (5.5 or 6.5) and peptides (0.6 or 0.1%) was studied here in anaerobic continuous cultures supplied with a mixed carbohydrate source. Final butyrate concentrations were markedly higher at pH 5.5 (0.6% peptide mean, 24.9 mM; 0.1% peptide mean, 13.8 mM) than at pH 6.5 (0.6% peptide mean, 5.3 mM; 0.1% peptide mean, 7.6 mM). At pH 5.5 and 0.6% peptide input, a high butyrate production coincided with decreasing acetate concentrations. The highest propionate concentrations (mean, 20.6 mM) occurred at pH 6.5 and 0.6% peptide input. In parallel, major bacterial groups were monitored by using fluorescence in situ hybridization with a panel of specific 16S rRNA probes. Bacteroides levels increased from ca. 20 to 75% of total eubacteria after a shift from pH 5.5 to 6.5, at 0.6% peptide, coinciding with high propionate formation. Conversely, populations of the butyrate-producing Roseburia group were highest (11 to 19%) at pH 5.5 but fell at pH 6.5, a finding that correlates with butyrate formation. When tested in batch culture, three Bacteroides species grew well at pH 6.7 but poorly at pH 5.5, which is consistent with the behavior observed for the mixed community. Two Roseburia isolates grew equally well at pH 6.7 and 5.5. These findings suggest that a lowering of pH resulting from substrate fermentation in the colon may boost butyrate production and populations of butyrate-producing bacteria, while at the same time curtailing the growth of Bacteroides spp.

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Authors: Walker, A. W., Duncan, S. H., McWilliam Leitch, E. C., Child, M. W., & Flint, H. J.
Affiliations: University of Aberdeen (GB)
Microbial Genetics Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, United Kingdom
University of Dundee (GB)
Corresponding author: Flint, Harry J.
ORCID: Walker, Alan W.
Duncan, Sylvia H.
Flint, Harry J.
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2005-07
Volume: 71
Issue: 7
Pages: 3692-3700
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.71.7.3692-3700.2005
PMC: PMC1169066
OpenAlex: W2160427027
Cited by: 796
References: 58
Citations by year: 2026: 37 · 2025: 59 · 2024: 56 · 2023: 47 · 2022: 74 · 2021: 65 · 2020: 57 · 2019: 46 · 2018: 47 · 2017: 41 · 2016: 47 · 2015: 28 · 2014: 27 · 2013: 29 · 2012: 23
FWCI: 6.02
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
Keywords: colonic microbiota, short-chain fatty acids, butyrate production, propionate, acetate, pH, dietary peptides, Bacteroides, Roseburia
MeSH terms: Anaerobiosis, Bacteria, Anaerobic, Bacteroides, Colon, Culture Media, Fatty Acids, Fermentation, Humans, Hydrogen-Ion Concentration, Peptides, RNA, Ribosomal, 16S, DNA Probes, In Situ Hybridization, Fluorescence, Ecosystem

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pH and Peptide Supply Can Radically Alter Bacterial Populations and Short-Chain Fatty Acid Ratios within Microbial Communities from the Human Colon

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