Cited by 856Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

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Two Routes of Metabolic Cross-Feeding between Bifidobacterium adolescentis and Butyrate-Producing Anaerobes from the Human Gut

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Belenguer, Alvaro, Duncan, Sylvia H., Calder, A. Graham, Holtrop, Grietje, Louis, Petra, Lobley, Gerald E., Flint, Harry J.·2006·Applied and Environmental Microbiology

DOI 10.1128/aem.72.5.3593-3599.2006

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Abstract

Dietary carbohydrates have the potential to influence diverse functional groups of bacteria within the human large intestine. Of 12 Bifidobacterium strains of human gut origin from seven species tested, four grew in pure culture on starch and nine on fructo-oligosaccharides. The potential for metabolic cross-feeding between Bifidobacterium adolescentis and lactate-utilizing, butyrate-producing Firmicute bacteria related to Eubacterium hallii and Anaerostipes caccae was investigated in vitro. E. hallii L2-7 and A. caccae L1-92 failed to grow on starch in pure culture, but in coculture with B. adolescentis L2-32 butyrate was formed, indicating cross-feeding of metabolites to the lactate utilizers. Studies with [ 13 C]lactate confirmed carbon flow from lactate, via acetyl coenzyme A, to butyrate both in pure cultures of E. hallii and in cocultures with B. adolescentis . Similar results were obtained in cocultures involving B. adolescentis DSM 20083 with fructo-oligosaccharides as the substrate. Butyrate formation was also stimulated, however, in cocultures of B. adolescentis L2-32 grown on starch or fructo-oligosaccharides with Roseburia sp. strain A2-183, which produces butyrate but does not utilize lactate. This is probably a consequence of the release by B. adolescentis of oligosaccharides that are available to Roseburia sp. strain A2-183. We conclude that two distinct mechanisms of metabolic cross-feeding between B. adolescentis and butyrate-forming bacteria may operate in gut ecosystems, one due to consumption of fermentation end products (lactate and acetate) and the other due to cross-feeding of partial breakdown products from complex substrates.

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Self-citation

Authors: Belenguer, A., Duncan, S. H., Calder, A. G., Holtrop, G., Louis, P., Lobley, G. E., & Flint, H. J.
Affiliations: Rowett Research Institute
Biomathematics and Statistics Scotland (GB)
ORCID: Duncan, Sylvia H.
Holtrop, Grietje
Louis, Petra
Flint, Harry J.
Venue: Applied and Environmental Microbiology
Publisher: American Society for Microbiology
Published: 2006-05
Volume: 72
Issue: 5
Pages: 3593-3599
ISSN: 0099-2240 (ISSN-L)
1098-5336
DOI: 10.1128/aem.72.5.3593-3599.2006
OpenAlex: W2064837899
Cited by: 856
References: 47
Citations by year: 2026: 63 · 2025: 55 · 2024: 53 · 2023: 51 · 2022: 75 · 2021: 57 · 2020: 52 · 2019: 58 · 2018: 62 · 2017: 59 · 2016: 34 · 2015: 31 · 2014: 30 · 2013: 33 · 2012: 29
FWCI: 8.85
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Applied and Environmental Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Caja de Ahorros de la Inmaculada de Aragón
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: cross-feeding, Bifidobacterium adolescentis, butyrate production, Eubacterium hallii, Anaerostipes caccae, Roseburia, lactate utilization, fructooligosaccharides, starch fermentation, gut microbiota, carbon flux, acetate, oligosaccharide release, co-culture
MeSH terms: Acetates, Bacteria, Anaerobic, Bifidobacterium, Butyrates, Culture Media, Digestive System, Fatty Acids, Fructose, Humans, Lactates, Oligosaccharides, Ecosystem

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Two Routes of Metabolic Cross-Feeding between Bifidobacterium adolescentis and Butyrate-Producing Anaerobes from the Human Gut

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