Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy
Abstract
Objective: To compare the efficacy of four therapeutic methods to modify gut microbiota dysbiosis and brain dysfunction in septic rats. Methods: Rats were treated with fecal microbiota transplantation, prebiotics, probiotics, and synbiotics after exposure to lipopolysaccharide. The diversity and composition of gut microbiota, electroencephalogram values, and the concentrations of TNF-α, IL-1β, and IL-6 in the cortex were analyzed. Results: Fecal microbiota transplantation was the most efficacious method to restore intestinal microbial diversity and exert the best corrective effects in modulating microbial composition in septic rats. More interestingly, fecal microbiota transplantation exerted the best protective effects in brain dysfunction in septic rats. Conclusion: Among the four methods, fecal microbiota transplantation was the most useful method to modify the dysbiosis of intestinal microbiota and improve brain function in septic rats. These findings reveal the protective consequence of microbiota modification, and the findings suggest opportunities to improve brain function in sepsis.
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FMT and probiotic treatment improve survival rate of patients with sepsis and alleviate symptoms of encephalopathy.
“Moreover, fecal microbiota transplantation (FMT) and probiotic treatment have been shown to improve the survival rate of patients with sepsis and alleviate the symptoms of encephalopathy (17, 18).”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [18]
FMT, probiotics, or certain drugs alleviate SAE by affecting the intestinal microbiota.
“In previous studies, FMT, probiotics, or certain drugs were shown to alleviate SAE by affecting the intestinal microbiota (18, 24).”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [18]
The gut microbiota may be an upstream regulator of SAE.
“These studies indicated that the gut microbiota may be an upstream regulator of SAE, which is consistent with our findings.”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [18]
Previous studies did not explore interindividual variability in SAE occurrence.
“However, these studies did not explore interindividual variability in SAE occurrence.”
From Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice (2022) · cites this paper as [18]
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- Authors
- Li, S., Guo, H., Xu, X., Hua, R., Zhao, Q., Li, J., Lv, J., & Li, J.
- Affiliations
- Hebei General Hospital (CN)
- Corresponding author
- Li, Suyan
- Guo, Hui
- Xu, Xin
- Hua, Ranliang
- Zhao, Qian
- Li, Jian
- Lv, Jian
- Li, Jianguo
- Venue
- Shock
- Published
- 2021-02-15
- Volume
- 56
- Issue
- 5
- Pages
- 824-831
- ISSN
- 1073-2322 (ISSN-L)
- 1540-0514
- OpenAlex
- W3132940832
- Cited by
- 18
- References
- 37
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Shock (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut dysbiosis, fecal microbiota transplantation, prebiotics, probiotics, synbiotics, sepsis, brain dysfunction, neuroinflammation, TNF-α, IL-1β, interleukin-6, EEG, intestinal microbial diversity
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Brain Diseases, Lipopolysaccharides, Male, Treatment Outcome, Rats, Sprague-Dawley, Probiotics, Rats, Prebiotics, Synbiotics, Dysbiosis
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