The DOI matches its Crossref record; 272 of the 272 references it cites were found in a registry or an index.
Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment
Open accessAbstract
SUMMARY: Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children in North America and one of the leading causes of death of infants less than 1 year of age worldwide, second only to malaria. Despite its global impact on human health, there are relatively few therapeutic options available to prevent or treat RSV infection. Paradoxically, there is a very large volume of information that is constantly being refined on RSV replication, the mechanisms of RSV-induced pathology, and community transmission. Compounding the burden of acute RSV infections is the exacerbation of preexisting chronic airway diseases and the chronic sequelae of RSV infection. A mechanistic link is even starting to emerge between asthma and those who suffer severe RSV infection early in childhood. In this article, we discuss developments in the understanding of RSV replication, pathogenesis, diagnostics, and therapeutics. We attempt to reconcile the large body of information on RSV and why after many clinical trials there is still no efficacious RSV vaccine and few therapeutics.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
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The Burden of Respiratory Syncytial Virus Infection in Young Children
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Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
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Cited by
Role of viral infections in the development and exacerbation of asthma in children
Jartti, T., & Gern, J. E. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.003 · Cited by 474
Off-season RSV epidemics in Australia after easing of COVID-19 restrictions
Eden, J.-S., Sikazwe, C., Xie, R., Deng, Y.-M., Sullivan, S. G., Michie, A., Levy, A., Cutmore, E., Blyth, C. C., Britton, P. N., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30485-3 · Cited by 340
Simonetti, B., Daly, J. L., & Cullen, P. J. (2023) · Traffic · doi:10.1111/tra.12885 · Cited by 39
Li, L., Wan, Y., Wang, Y., Tao, Y., Long, X., Liu, E., & Deng, Y. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04066-5 · Cited by 2
Metadata
- Authors
- Griffiths, C., Drews, S. J., & Marchant, D. J.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2017-01
- Volume
- 30
- Issue
- 1
- Pages
- 277-319
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2558274900
- Cited by
- 586
- References
- 272
- FWCI
- 27.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Griffiths, C., Drews, S. J., & Marchant, D. J. (2017). Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00010-16
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
