Cited by 113Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

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Heterologous Expression of Candida albicans Cell Wall-Associated Adhesins in Saccharomyces cerevisiae Reveals Differential Specificities in Adherence and Biofilm Formation and in Binding Oral Streptococcus gordonii

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Nobbs, Angela H., Vickerman, M. Margaret, Jenkinson, Howard F.·2010·Eukaryotic Cell

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Abstract

Colonization and infection of the human host by opportunistic pathogen Candida albicans derive from an ability of this fungus to colonize mucosal tissues and prosthetic devices within the polymicrobial communities present. To determine the functions of C. albicans cell wall proteins in interactions with host or bacterial molecules, Saccharomyces cerevisiae was utilized as a surrogate host to express C. albicans cell wall proteins Als3p, Eap1p, Hwp1p, and Rbt1p. Salivary pellicle and fibrinogen were identified as novel substrata for Als3p and Hwp1p, while only Als3p mediated adherence of S. cerevisiae to basement membrane collagen type IV. Parental S. cerevisiae cells failed to form biofilms on salivary pellicle, polystyrene, or silicone, but cells expressing Als3p or Hwp1p exhibited significant attachment to each surface. Virulence factor Rbt1p also conferred lower-level binding to salivary pellicle and polystyrene. S. cerevisiae cells expressing Eap1p formed robust biofilms upon polystyrene surfaces but not salivary pellicle. Proteins Als3p and Eap1p, and to a lesser degree Hwp1p, conferred upon S. cerevisiae the ability to bind cells of the oral primary colonizing bacterium Streptococcus gordonii . These interactions, which occurred independently of amyloid aggregate formation, provide the first examples of specific C. albicans surface proteins serving as receptors for bacterial adhesins. Streptococcus gordonii did not bind parental S. cerevisiae or cells expressing Rbt1p. Taken collectively, these data suggest that a network of cell wall proteins comprising Als3p, Hwp1p, and Eap1p, with complementary adhesive functions, promotes interactions of C. albicans with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities.

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Authors: Nobbs, A. H., Vickerman, M. M., & Jenkinson, H. F.
Affiliations: University of Bristol (GB)
University at Buffalo, State University of New York (US)
ORCID: Nobbs, Angela H.
Vickerman, M. Margaret
Jenkinson, Howard F.
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2010-10
Volume: 9
Issue: 10
Pages: 1622-1634
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.00103-10
PMC: PMC2950433
OpenAlex: W2124198277
Cited by: 112
References: 52
Citations by year: 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 12 · 2012: 8
FWCI: 6.64
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Explore Bristol Research (submittedVersion)
Funders: Johns Hopkins University
National Institutes of Health
National Institute of Dental and Craniofacial Research (R01DE016690)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: Candida albicans, Streptococcus gordonii, biofilm formation, fungal adhesion, salivary pellicle, fibrinogen, type IV collagen, polymicrobial communities, fungal-bacterial interactions, heterologous expression in yeast, opportunistic fungal infection, host colonization
MeSH terms: Candida albicans, Cell Adhesion, Cell Wall, Fungal Proteins, Humans, Mouth, Receptors, Cell Surface, Saccharomyces cerevisiae, Biofilms, Dental Pellicle, Streptococcus gordonii

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Heterologous Expression of Candida albicans Cell Wall-Associated Adhesins in Saccharomyces cerevisiae Reveals Differential Specificities in Adherence and Biofilm Formation and in Binding Oral Streptococcus gordonii

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