Cited by 88Bacterial biofilms and quorum sensingOral microbiology and periodontitis researchAntifungal resistance and susceptibility

Streptococcus gordonii comCDE (competence) operon modulates biofilm formation with Candida albicans

Open access
Jack, Alison A., Daniels, Debbie E., Jepson, Mark A., Vickerman, M. Margaret, Lamont, Richard J., Jenkinson, Howard F., Nobbs, Angela H.·2015·Microbiology

Abstract

Candida albicans is a pleiomorphic fungus that forms mixed species biofilms with Streptococcus gordonii, an early colonizer of oral cavity surfaces. Activation of quorum sensing (QS; intercellular signalling) promotes monospecies biofilm development by these micro-organisms, but the role of QS in mixed species communities is not understood. The comCDE genes in S. gordonii encode a sensor-regulator system (ComDE), which is activated by the comC gene product (CSP, competence stimulating peptide) and modulates expression of QS-regulated genes. Dual species biofilms of S. gordonii ΔcomCDE or ΔcomC mutants with C. albicans showed increased biomass compared to biofilms of S. gordonii DL1 wild-type with C. albicans. The ΔcomCDE mutant dual species biofilms in particular contained more extracellular DNA (eDNA), and could be dispersed with DNase I or protease treatment. Exogenous CSP complemented the S. gordonii ΔcomC transformation deficiency, as well as the ΔcomC-C. albicans biofilm phenotype. Purified CSP did not affect C. albicans hyphal filament formation but inhibited monospecies biofilm formation by C. albicans. The results suggest that the S. gordonii comCDE QS-system modulates the production of eDNA and the incorporation of C. albicans into dual species biofilms.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1099/mic.0.000010

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several studies have investigated dual-species biofilms comprising Candida albicans and a bacterium commonly isolated from denture stomatitis, periodontitis, or dental caries, such as Streptococcus mutans, Streptococcus gordonii, Actinomyces viscosus, or Fusobacterium species.

    “Several studies have investigated such dual-species biofilms comprising C. albicans and a bacterium commonly isolated from denture stomatitis, periodontitis, or dental caries, such as Streptococcus mutans, Streptococcus gordonii, Actinomyces viscosus, or Fusobacterium species (12, 81, 82).”

    From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [81]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Jack, A. A., Daniels, D. E., Jepson, M. A., Vickerman, M. M., Lamont, R. J., Jenkinson, H. F., & Nobbs, A. H.
Affiliations
  • University of Bristol (GB)
  • University at Buffalo, State University of New York (US)
  • University of Louisville (US)
Venue
Microbiology
Published
2015-02-01
Volume
161
Issue
2
Pages
411-421
ISSN
  • 1350-0872 (ISSN-L)
  • 1465-2080
OpenAlex
W2022415795
Cited by
88
References
55
Citations by year
2026: 1 · 2025: 6 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 8 · 2015: 8
FWCI
3.55
Type
journal article
Language
en
Open access
Locations
  • Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion)
  • Explore Bristol Research (submittedVersion)
Funders
  • University of Bristol
  • National Institutes of Health
  • National Institute of Dental and Craniofacial Research (DE016690, R01DE016690)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
Streptococcus gordonii, Candida albicans, competence-stimulating peptide, quorum sensing, dual-species biofilms, extracellular DNA, biofilm dispersal, dental plaque, hyphal development
MeSH terms
Bacterial Proteins, Candida albicans, Candidiasis, DNA, Bacterial, Humans, Operon, Streptococcal Infections, Biofilms, Quorum Sensing, Streptococcus gordonii

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review