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Commensal Bacteroidetes protect against Klebsiella pneumoniae colonization and transmission through IL-36 signalling

Sequeira, R. P., McDonald, J. A. K., Marchesi, J. R., & Clarke, T. B. (2020) · Nature Microbiology · doi:10.1038/s41564-019-0640-1 · Cited by 132 · see citing works

Microbiota and host immune responses: a love–hate relationship

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Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases

van den Elsen, L. W. J., Poyntz, H., Weyrich, L. S., Young, W., & Forbes‐Blom, E. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2016.91 · Cited by 127 · see citing works

Age-related changes in intestinal immunity and the microbiome

Walrath, T., Dyamenahalli, K. U., Hulsebus, H. J., McCullough, R. L., Idrovo, J., Boe, D. M., McMahan, R. H., & Kovacs, E. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0620-405rr · Cited by 124 · see citing works

Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota

Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 136 · see citing works

Bacterial-Host Interactions: Physiology and Pathophysiology of Respiratory Infection

Håkansson, A., Orihuela, C. J., & Bogaert, D. (2018) · Physiological Reviews · doi:10.1152/physrev.00040.2016 · Cited by 126 · see citing works

Microbiomes in respiratory health and disease: An Asia‐Pacific perspective

Chotirmall, S. H., Gellatly, S. L., Budden, K. F., Aogáin, M. M., Shukla, S. D., Wood, D., Hugenholtz, P., Pethe, K., & Hansbro, P. M. (2017) · Respirology · doi:10.1111/resp.12971 · Cited by 122 · see citing works

Bronchiectasis: Current Concepts in Pathogenesis, Immunology, and Microbiology

Boyton, R. J., & Altmann, D. M. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012615-044344 · Cited by 112 · see citing works

The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung

Galvão, I., Tavares, L. P., Corrêa, R. O., Fachi, J. L., Rocha, V. M., Rungue, M., Garcia, C. C., Cassali, G. D., Ferreira, C. M., Martins, F. S., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00142 · Cited by 107 · see citing works

The regulation of host defences to infection by the microbiota

Brown, R. L., & Clarke, T. B. (2016) · Immunology · doi:10.1111/imm.12634 · Cited by 103 · see citing works

Microbiota—myeloid cell crosstalk beyond the gut

Gorjifard, S., & Goldszmid, R. S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0516-222r · Cited by 97 · see citing works

Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study

Lankelma, J. M., Cranendonk, D. R., Belzer, C., de Vos, A. F., de Vos, W. M., van der Poll, T., & Wiersinga, W. J. (2016) · Gut · doi:10.1136/gutjnl-2016-312132 · Cited by 94 · see citing works

Alterations in the Gut Microbiome and Cecal Metabolome During Klebsiella pneumoniae-Induced Pneumosepsis

Wu, T. H., Xu, F., Su, C., Li, H., Lv, N., Liu, Y., Gao, Y., Lan, Y., & Li, J.-B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01331 · Cited by 93 · see citing works

Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses

Yitbarek, A., Taha-Abdelaziz, K., Hodgins, D. C., Read, L. R., Nagy, É., Weese, J. S., Caswell, J., Parkinson, J., & Sharif, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31613-0 · Cited by 90 · see citing works

Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis

Khan, N., Mendonca, L., Dhariwal, A., Fontès, G., Menzies, D., Xia, J., Divangahi, M., & King, I. L. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0147-3 · Cited by 92 · see citing works

Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity

Jordan, C. K. I., Brown, R. L., Larkinson, M. L. Y., Sequeira, R. P., Edwards, A. M., & Clarke, T. B. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.07.008 · Cited by 88 · see citing works

Early recognition of sacroiliitis by magnetic resonance imaging and single photon emission computed tomography.

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The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract

Perdijk, O., Azzoni, R., & Marsland, B. J. (2023) · Physiological Reviews · doi:10.1152/physrev.00020.2023 · Cited by 87 · see citing works

Commensal Microbiota Regulate Vertebrate Innate Immunity-Insights From the Zebrafish

Murdoch, C. C., & Rawls, J. F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02100 · Cited by 79 · see citing works

Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages

Wu, T., Li, H., Su, C., Xu, F., Yang, G., Sun, K., Xu, M., Lv, N., Meng, B., Liu, Y., et al. (2020) · mSystems · doi:10.1128/msystems.00587-20 · Cited by 78 · see citing works

Linking microbiota and respiratory disease

Hauptmann, M., & Schaible, U. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12421 · Cited by 75 · see citing works

Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection

Li, K.-L., Wang, B., Li, Z., Li, Y., & Liang, J. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00248-0 · Cited by 77 · see citing works

From Klebsiella pneumoniae Colonization to Dissemination: An Overview of Studies Implementing Murine Models

Joseph, L., Merciecca, T., Forestier, C., Balestrino, D., & Miquel, S. (2021) · Microorganisms · doi:10.3390/microorganisms9061282 · Cited by 72 · see citing works

Immunomodulatory Effects of Lactobacillus plantarum on Inflammatory Response Induced by Klebsiella pneumoniae

Vareille-Delarbre, M., Miquel, S., Garcin, S., Bertran, T., Balestrino, D., Evrard, B., & Forestier, C. (2019) · Infection and Immunity · doi:10.1128/iai.00570-19 · Cited by 70 · see citing works

Crosstalk between gut microbiota and sepsis

Niu, M., & Chen, P. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab036 · Cited by 69 · see citing works

Current Findings on Gut Microbiota Mediated Immune Modulation against Viral Diseases in Chicken

Abaidullah, M., Peng, S., Kamran, M., Song, X., & Yin, Z. (2019) · Viruses · doi:10.3390/v11080681 · Cited by 68 · see citing works

Relationship between gut microbiota and lung function decline in patients with chronic obstructive pulmonary disease: a 1-year follow-up study

Chiu, Y.-C., Lee, S.-W., Liu, C.-W., Lan, T.-Y., & Wu, L. S.-H. (2022) · Respiratory Research · doi:10.1186/s12931-022-01928-8 · Cited by 67 · see citing works

Could Perturbation of Gut Microbiota Possibly Exacerbate the Severity of COVID-19 via Cytokine Storm?

Vignesh, R., Swathirajan, C. R., Tun, Z. H., Rameshkumar, M. R., Solomon, S. S., & Balakrishnan, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607734 · Cited by 64 · see citing works

Dietary Supplementation With Nonfermentable Fiber Alters the Gut Microbiota and Confers Protection in Murine Models of Sepsis

Morowitz, M. J., Caro, V. D., Pang, D., Cummings, J. L., Firek, B., Rogers, M. B., Ranganathan, S., Clark, R. S. B., & Aneja, R. K. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002291 · Cited by 61 · see citing works

Role of the Microbiome in Interstitial Lung Diseases

Chioma, O. S., Hesse, L. E., Chapman, A., & Drake, W. P. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.595522 · Cited by 64 · see citing works

Respiratory and Intestinal Microbiota in Pediatric Lung Diseases—Current Evidence of the Gut–Lung Axis

Stricker, S., Hain, T., Chao, C., & Rudloff, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126791 · Cited by 60 · see citing works

Gut microbiota modulates type I interferon and antibody-mediated immune responses in chickens infected with influenza virus subtype H9N2

Yitbarek, A., Alkie, T. N., Taha-Abdelaziz, K., Astill, J., Rodriguez-Lecompte, J. C., Parkinson, J., Nagy, É., & Sharif, S. (2018) · Beneficial Microbes · doi:10.3920/bm2017.0088 · Cited by 59 · see citing works

Gut-Lung Microbiota in Chronic Pulmonary Diseases: Evolution, Pathogenesis, and Therapeutics

Shi, C. Y., Yu, C.-H., Yu, W. Y., & Ying, H. (2021) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2021/9278441 · Cited by 58 · see citing works

The microbiome at the pulmonary alveolar niche and its role in Mycobacterium tuberculosis infection

Adami, A. J., & Cervantes, J. (2015) · Tuberculosis · doi:10.1016/j.tube.2015.07.004 · Cited by 56 · see citing works

Gut Microbiome and Organ Fibrosis

Costa, C. F. F. A., Sampaio‐Maia, B., Araújo, R., Nascimento, D. S., Ferreira‐Gomes, J., Pestana, M., Azevedo, M. J., & Alencastre, I. S. (2022) · Nutrients · doi:10.3390/nu14020352 · Cited by 51 · see citing works

The gut microbiota as a modulator of innate immunity during melioidosis

Lankelma, J. M., Birnie, E., Weehuizen, T. A. F., Scicluna, B. P., Belzer, C., Houtkooper, R. H., Roelofs, J. J. T. H., de Vos, A. F., van der Poll, T., Budding, A. E., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005548 · Cited by 50 · see citing works

Immunological design of commensal communities to treat intestinal infection and inflammation

Brown, R. L., Larkinson, M. L. Y., & Clarke, T. B. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009191 · Cited by 48 · see citing works

The role of the innate immune system on pulmonary infections

Galeas‐Pena, M., McLaughlin, N., & Pociask, D. A. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0304 · Cited by 48 · see citing works

Long-distance relationships - regulation of systemic host defense against infections by the gut microbiota

Schlechte, J., Skalosky, I., Geuking, M. B., & McDonald, B. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00539-2 · Cited by 47 · see citing works

Differential Sensitivity to Plasmodium yoelii Infection in C57BL/6 Mice Impacts Gut-Liver Axis Homeostasis

Denny, J. E., Powers, J. B., Castro, H. F., Zhang, J., Joshi‐Barve, S., Campagna, S. R., & Schmidt, N. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-40266-6 · Cited by 47 · see citing works

Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections

Zhu, W., Wu, Y., Liu, H., Jiang, C., & Huo, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741233 · Cited by 46 · see citing works

Research advancements on the diversity and host interaction of gut microbiota in chickens

Yue, Y., Luasiri, P., Li, J., Laosam, P., & Sangsawad, P. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1492545 · Cited by 44 · see citing works

Lactobacillus salivarius ameliorated Mycoplasma gallisepticum-induced inflammatory injury and secondary Escherichia coli infection in chickens: Involvement of intestinal microbiota

Wang, J., Ishfaq, M., & Li, J. (2021) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2021.110192 · Cited by 44 · see citing works

Microbiome Modulation as a Novel Strategy to Treat and Prevent Respiratory Infections

Mindt, B. C., & DiGiandomenico, A. (2022) · Antibiotics · doi:10.3390/antibiotics11040474 · Cited by 44 · see citing works

Lung Microbiome Participation in Local Immune Response Regulation in Respiratory Diseases

Lira-Lucio, J. A., Falfán‐Valencia, R., Ramírez‐Venegas, A., Buendía-Roldán, I., Rojas‐Serrano, J., Mejía, M. E., & Pérez-Rubio, G. (2020) · Microorganisms · doi:10.3390/microorganisms8071059 · Cited by 41 · see citing works

Relationship between intestinal microbiota, diet and biological systems: an integrated view

Ferreira, R. D. S., Mendonça, L. A. B. M., Ribeiro, C. F. A., Calças, N. C., Guimarães, R. D. C. A., do Nascimento, V. A., Freitas, K. D. C., Carvalho, C. M. E., de Castro, A. P., & Franco, O. L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1836605 · Cited by 41 · see citing works

NOD1 in the interplay between microbiota and gastrointestinal immune adaptations

Fernández-García, V., González-Ramos, S., Martín‐Sanz, P., del Portillo, F. G., Laparra, J. M., & Boscá, L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105775 · Cited by 41 · see citing works

Strategies for enhancing immunity against avian influenza virus in chickens: a review

Alqazlan, N. M., Astill, J., Raj, S., & Sharif, S. (2022) · Avian Pathology · doi:10.1080/03079457.2022.2054309 · Cited by 40 · see citing works

Microbial Programming of Systemic Innate Immunity and Resistance to Infection

Clarke, T. B. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004506 · Cited by 40 · see citing works

The influence of the commensal microbiota on distal tumor-promoting inflammation

Rosean, C. M. B., & Rutkowski, M. R. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.06.002 · Cited by 39 · see citing works

Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity

Cheng, M., Chen, Y., Wang, L., Chen, W., Yang, L., Shen, G., Xu, T., Shen, G., Tian, Z., & Hu, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-08264-8 · Cited by 38 · see citing works

The Human Respiratory Microbiome: Implications and Impact

Mitchell, A. B., & Glanville, A. R. (2018) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0037-1617441 · Cited by 37 · see citing works

The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

Weinberg, F. D., Dickson, R. P., Nagrath, D., & Ramnath, N. (2020) · Cancers · doi:10.3390/cancers13010013 · Cited by 38 · see citing works

How does the microbiota control systemic innate immunity?

Jordan, C. K. I., & Clarke, T. B. (2024) · Trends in Immunology · doi:10.1016/j.it.2023.12.002 · Cited by 37 · see citing works

Gut microbes improve prognosis of Klebsiella pneumoniae pulmonary infection through the lung-gut axis

Tang, Y., Chen, L., Yang, J., Zhang, S., Jin, J., & Yao, W. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1392376 · Cited by 38 · see citing works

Novel cancer therapy targeting microbiome

Nagano, T., Otoshi, T., Hazama, D., Kiriu, T., Umezawa, K., Katsurada, N., & Nishimura, Y. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s207546 · Cited by 35 · see citing works

The Lung Microbiome

Lipinksi, J. H., Ranjan, P., Dickson, R. P., & O’Dwyer, D. N. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300716 · Cited by 34 · see citing works

Precision respiratory medicine and the microbiome

Rogers, G. B., & Wesselingh, S. L. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00476-2 · Cited by 32 · see citing works

Commensal Microbiome Promotes Resistance to Local and Systemic Infections

Zhang, N., & He, Q. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.162502 · Cited by 34 · see citing works

From sensing to shaping microbiota: insights into the role of NOD2 in intestinal homeostasis and progression of Crohn’s disease

Balasubramanian, I., & Gao, N. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00330.2016 · Cited by 34 · see citing works

Innate Immune Response and Outcome of Clostridium difficile Infection Are Dependent on Fecal Bacterial Composition in the Aged Host

Shin, J. H., Gao, Y., Moore, J. H., Bolick, D. T., Kolling, G. L., Wu, M., & Warren, C. A. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix414 · Cited by 33 · see citing works

Bacterial Gut Microbiota and Infections During Early Childhood

George, S., Aguilera, X., Gallardo, P., Farfán, M. J., Lucero, Y., Torres, J. P., Vidal, R. M., & O’Ryan, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.793050 · Cited by 33 · see citing works

Horizontal transmission of gut microbiota attenuates mortality in lung fibrosis

Gurczynski, S. J., Lipinski, J. H., Strauss, J., Alam, S., Huffnagle, G. B., Ranjan, P., Kennedy, L. H., Moore, B. B., & O’Dwyer, D. N. (2023) · JCI Insight · doi:10.1172/jci.insight.164572 · Cited by 31 · see citing works

The Interplay between Antibiotics and the Host Immune Response in Sepsis: From Basic Mechanisms to Clinical Considerations: A Comprehensive Narrative Review

Tosi, M., Coloretti, I., Meschiari, M., Biasi, S. D., Girardis, M., & Busani, S. (2024) · Antibiotics · doi:10.3390/antibiotics13050406 · Cited by 32 · see citing works

A Porcine Ex Vivo Lung Perfusion Model To Investigate Bacterial Pathogenesis

Dumigan, A., Fitzgerald, M., Sá‐Pessoa, J., Hamid, U. I., O’Kane, C. M., McAuley, D. F., & Bengoechea, J. A. (2019) · mBio · doi:10.1128/mbio.02802-19 · Cited by 29 · see citing works

Antibiotic-Induced Gut Microbiota Disruption Decreases TNF-α Release by Mononuclear Cells in Healthy Adults

Lankelma, J. M., Belzer, C., Hoogendijk, A. J., de Vos, A. F., de Vos, W. M., van der Poll, T., & Wiersinga, W. J. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.43 · Cited by 28 · see citing works

Virulence factors of Klebsiella pneumoniae: Insights into canonical and emerging mechanisms driving pathogenicity and drug resistance

Singh, R. P., Kapoor, A., Sinha, A., Ma, Y., & Shankar, M. (2025) · The Microbe · doi:10.1016/j.microb.2025.100289 · Cited by 27 · see citing works

Host–microbe cross-talk in the lung microenvironment: implications for understanding and treating chronic lung disease

Gosens, R., Hiemstra, P. S., Adcock, I. M., Bracke, K. R., Dickson, R. P., Hansbro, P. M., Krauss‐Etschmann, S., Smits, H. H., Stassen, F. R. M., & Bartel, S. (2020) · European Respiratory Journal · doi:10.1183/13993003.02320-2019 · Cited by 26 · see citing works

A respiratory commensal bacterium acts as a risk factor for Mycoplasma gallisepticum infection in chickens

Wang, J., Ishfaq, M., Fan, Q., Chen, C., & Li, J. (2020) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2020.110127 · Cited by 27 · see citing works

Gut microbiota nexus: Exploring the interactions with the brain, heart, lungs, and skin axes and their effects on health

Chakraborty, P., Banerjee, D., Majumder, P., & Sarkar, J. (2024) · Medicine in Microecology · doi:10.1016/j.medmic.2024.100104 · Cited by 27 · see citing works

UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis

Chen, Y., Hao, X., Li, M., Tian, Z., & Cheng, M. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00338-8 · Cited by 25 · see citing works

The Role of Gut Microbiota in the Clinical Outcome of Septic Patients: State of the Art and Future Perspectives

Marascio, N., Scarlata, G. G. M., Romeo, F., Cicino, C., Trecarichi, E. M., Quirino, A., Torti, C., Matera, G., & Russo, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119307 · Cited by 25 · see citing works

The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes

Bastos, H. N., Osório, N. S., Gagneux, S., Comas, I., & Saraiva, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01948 · Cited by 23 · see citing works

Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis

Wolff, N. S., Jacobs, M. C., Wiersinga, W. J., & Hugenholtz, F. (2021) · Intensive Care Medicine Experimental · doi:10.1186/s40635-021-00398-4 · Cited by 22 · see citing works

Therapeutic implications of SARS-CoV-2 dysregulation of the gut-brain-lung axis

Johnson, S. D., Olwenyi, O. A., Bhyravbhatla, N., Thurman, M., Pandey, K., Klug, E., Johnston, M., Dyavar, S. R., Acharya, A., Podany, A. T., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i29.4763 · Cited by 22 · see citing works

Commensal Microflora Contribute to Host Defense Against Escherichia Coli Pneumonia Through Toll-Like Receptors

Chen, L.-W., Chen, P.-H., & Hsu, C.-M. (2011) · Shock · doi:10.1097/shk.0b013e3182184ee7 · Cited by 104 · see citing works

Commensal microflora induce host defense to E.coli pneumonia through toll-like receptors (133.13)

Chen, L.-W., & Hsu, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.supp.133.13

Gut flora enhance bacterial clearance in lung through toll-like receptors 4

Tsay, T.-B., Yang, M.-C., Chen, P.-H., Hsu, C.-M., & Chen, L.-W. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-68 · Cited by 49 · see citing works

Articles of Significant Interest Selected from This Issue by the Editors

(2014) · Infection and Immunity · doi:10.1128/iai.02616-14

Nod-like receptors in intestinal host defense

Robertson, S. J., & Girardin, S. E. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835a68ea · Cited by 33 · see citing works