The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Role of the Accessory Gene Regulator agr in Community-Associated Methicillin-Resistant Staphylococcus aureus Pathogenesis
Open accessAbstract
The molecular basis underlying the pathogenic success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is not completely understood, but differential gene expression has been suggested to account at least in part for the high virulence of CA-MRSA strains. Here, we show that the agr gene regulatory system has a crucial role in the development of skin infections in the most prevalent CA-MRSA strain USA300. Importantly, our data indicate that this is due to discrepancies between the agr regulon of CA-MRSA and those of hospital-associated MRSA and laboratory strains. In particular, agr regulation in strain USA300 led to exceptionally strong expression of toxins and exoenzymes, upregulation of fibrinogen-binding proteins, increased capacity to bind fibrinogen, and increased expression of methicillin resistance genes. Our findings demonstrate that agr functionality is critical for CA-MRSA disease and indicate that an adaptation of the agr regulon contributed to the evolution of highly pathogenic CA-MRSA.
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Citations
Cites
1 retracted
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues
Cheng, A. G., Kim, H. K., Burts, M. L., Krausz, T., Schneewind, O., & Missiakas, D. M. (2009) · The FASEB Journal · doi:10.1096/fj.09-135467 · Cited by 437
RetractedKlevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · cited 1×
“Pandemic community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains represent a serious problem for the public health system (25).”
BackgroundMethicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046
Self-citationPoring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
Bubeck Wardenburg, J., Bae, T., Otto, M., DeLeo, F. R., & Schneewind, O. (2007) · Nature Medicine · doi:10.1038/nm1207-1405 · Cited by 492
Self-citationBasis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457
Self-citationEvolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
Li, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394
Self-citationKennedy, A. D., Wardenburg, J. B., Gardner, D. J., Long, D., Whitney, A. R., Braughton, K. R., Schneewind, O., & DeLeo, F. R. (2010) · The Journal of Infectious Diseases · doi:10.1086/656043 · Cited by 335
Host defense and pathogenesis in Staphylococcus aureus infections
DeLeo, F. R., Diep, B. A., & Otto, M. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2008.10.003 · Cited by 269 · cited 8×
“aureus may secrete toxins that lyse human neutrophils and other immune cells, such as alpha-toxin, phenol-soluble modulins (PSMs), and members of the leukocidin family, which include Panton-Valentine leukocidin (PVL) (12, 18).”
BackgroundInfluentialSelf-citationWardenburg, J. B., Palazzolo‐Ballance, A. M., Otto, M., Schneewind, O., & DeLeo, F. R. (2008) · The Journal of Infectious Diseases · doi:10.1086/592053 · Cited by 236
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Cited by
Tong, S. Y. C., Davis, J. S., Eichenberger, E., Holland, T. L., & Fowler, V. G. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00134-14 · Cited by 5,192
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,380
Self-citationKolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W.-Y., Sanz, M.-J., Mowen, K., Opdenakker, G., & Kubes, P. (2015) · Nature Communications · doi:10.1038/ncomms7673 · Cited by 584
Regulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
Quorum-sensing regulation in staphylococci—an overview
Le, K. Y., & Otto, M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01174 · Cited by 490
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Metadata
- Authors
- Cheung, G. Y. C., Wang, R., Khan, B. A., Sturdevant, D. E., & Otto, M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2011-05
- Volume
- 79
- Issue
- 5
- Pages
- 1927-1935
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2149548525
- Cited by
- 319
- References
- 11
- FWCI
- 12.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheung, G. Y. C., Wang, R., Khan, B. A., Sturdevant, D. E., & Otto, M. (2011). Role of the Accessory Gene Regulator agr in Community-Associated Methicillin-Resistant Staphylococcus aureus Pathogenesis. Infection and Immunity. https://doi.org/10.1128/iai.00046-11
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