The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework
Open accessAbstract
Historically, the nature and extent of host damage by a microbe were considered highly dependent on virulence attributes of the microbe. However, it has become clear that disease is a complex outcome which can arise because of pathogen-mediated damage, host-mediated damage, or both, with active participation from the host microbiota. This awareness led to the formulation of the damage response framework (DRF), a revolutionary concept that defined microbial virulence as a function of host immunity. The DRF outlines six classifications of host damage outcomes based on the microbe and the strength of the immune response. In this review, we revisit this concept from the perspective of Candida albicans , a microbial pathogen uniquely adapted to its human host. This fungus commonly colonizes various anatomical sites without causing notable damage. However, depending on environmental conditions, a diverse array of diseases may occur, ranging from mucosal to invasive systemic infections resulting in microbe-mediated and/or host-mediated damage. Remarkably, C. albicans infections can fit into all six DRF classifications, depending on the anatomical site and associated host immune response. Here, we highlight some of these diverse and site-specific diseases and how they fit the DRF classifications, and we describe the animal models available to uncover pathogenic mechanisms and related host immune responses.
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Cites
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Cited by
Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
Talapko, J., Juzbašić, M., Matijević, T., Pustijanac, E., Bekić, S., Kotris, I., & Škrlec, I. (2021) · Journal of Fungi · doi:10.3390/jof7020079 · Cited by 794
Oral Candidiasis: A Disease of Opportunity
Vila, T., Sultan, A. S., Montelongo-Jauregui, D., & Jabra-Rizk, M. A. (2020) · Journal of Fungi · doi:10.3390/jof6010015 · Cited by 537
Self-citationVulvovaginal Candidiasis: A Current Understanding and Burning Questions
Willems, H. M. E., Ahmed, S. S., Liu, J., Xu, Z., & Peters, B. M. (2020) · Journal of Fungi · doi:10.3390/jof6010027 · Cited by 357
Dadar, M., Tiwari, R., Karthik, K., Chakraborty, S., Shahali, Y., & Dhama, K. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.02.028 · Cited by 332
Lu, S.-Y. (2021) · Journal of Fungi · doi:10.3390/jof7070555 · Cited by 118
Metadata
- Authors
- Jabra-Rizk, M. A., Kong, E. F., Tsui, C., Nguyen, M. H., Clancy, C. J., Fidel, P. L., & Noverr, M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2016-10
- Volume
- 84
- Issue
- 10
- Pages
- 2724-2739
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2500842273
- Cited by
- 182
- References
- 30
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Jabra-Rizk, M. A., Kong, E. F., Tsui, C., Nguyen, M. H., Clancy, C. J., Fidel, P. L., & Noverr, M. (2016). Candida albicans Pathogenesis: Fitting within the Host-Microbe Damage Response Framework. Infection and Immunity. https://doi.org/10.1128/iai.00469-16
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