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Cited by 42Parasites and Host InteractionsInflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways

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Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

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Wangchuk, Phurpa, Shepherd, Catherine, Constantinoiu, Constantin, Ryan, Rachael Y. M., Kouremenos, Konstantinos A., Becker, Luke, Jones, Linda, Buitrago, Geraldine, Giacomin, Paul, Wilson, David, Daly, Norelle, McConville, Malcolm J., Miles, John J., Loukas, Alex·2019·Infection and Immunity
DOI 10.1128/iai.00851-18PMC PMC6434117

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Abstract

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral blood mononuclear cells, we demonstrated that low-molecular-weight metabolites derived from both somatic extracts (LMWM-SE) and excretory-secretory products (LMWM-ESP) of the hookworm, Ancylostoma caninum , display anti-inflammatory properties.

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Metadata

Authors
Wangchuk, P., Shepherd, C., Constantinoiu, C., Ryan, R. Y. M., Kouremenos, K. A., Becker, L., Jones, L., Buitrago, G., Giacomin, P., Wilson, D., Daly, N., McConville, M. J., Miles, J. J., & Loukas, A.
Affiliations
  • Australian Institute of Tropical Health and Medicine (AU)
  • James Cook University (AU)
  • The University of Melbourne (AU)
ORCID
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
2019-04
Volume
87
Issue
4
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.00851-18
PMC
PMC6434117
OpenAlex
W2913986919
Cited by
42
References
1
Citations by year
2026: 3 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 9 · 2019: 2
FWCI
4.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Infection and Immunity (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ResearchOnline at James Cook University (James Cook University) (submittedVersion)
Funders
Department of Health | National Health and Medical Research Council (APP1091011, APP1037304, APP1117504, APP1131732)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
Ancylostoma caninum, inflammatory bowel disease, colitis, excretory-secretory products, low molecular weight metabolites, anti-inflammatory activity, inflammatory cytokines, peripheral blood mononuclear cells, immunomodulation
MeSH terms
Ancylostoma, Animals, Anti-Inflammatory Agents, Biological Therapy, Colitis, Disease Models, Animal, Fatty Acids, Female, Humans, Leukocytes, Mononuclear, Male, Mice, Inbred BALB C, Cytokines, Mice

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