Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasis
Open accessAbstract
Oropharyngeal candidiasis (OPC; thrush) is an opportunistic fungal infection caused by the commensal microbe Candida albicans. Immunity to OPC is strongly dependent on CD4+ T cells, particularly those of the Th17 subset. Interleukin-17 (IL-17) deficiency in mice or humans leads to chronic mucocutaneous candidiasis, but the specific downstream mechanisms of IL-17-mediated host defense remain unclear. Lipocalin 2 (Lcn2; 24p3; neutrophil gelatinase-associated lipocalin [NGAL]) is an antimicrobial host defense factor produced in response to inflammatory cytokines, particularly IL-17. Lcn2 plays a key role in preventing iron acquisition by bacteria that use catecholate-type siderophores, and lipocalin 2(-/-) mice are highly susceptible to infection by Escherichia coli and Klebsiella pneumoniae. The role of Lcn2 in mediating immunity to fungi is poorly defined. Accordingly, in this study, we evaluated the role of Lcn2 in immunity to oral infection with C. albicans. Lcn2 is strongly upregulated following oral infection with C. albicans, and its expression is almost entirely abrogated in mice with defective IL-17 signaling (IL-17RA(-/-) or Act1(-/-) mice). However, Lcn2(-/-) mice were completely resistant to OPC, comparably to wild-type (WT) mice. Moreover, Lcn2 deficiency mediated protection from OPC induced by steroid immunosuppression. Therefore, despite its potent regulation during C. albicans infection, Lcn2 is not required for immunity to mucosal candidiasis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-17 induces NGAL transcription and NGAL interferes with microbial iron uptake via siderophores.
“For example, IL-17 induces NGAL transcription and NGAL interferes with microbial iron uptake via siderophores (Ferreira et al., 2013).”
From Iron in infection and immunity (2020) · cites this paper as Ferreira et al., 2013
Cites
Hidden Killers: Human Fungal Infections
Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004404 · Cited by 4,284 · see citing works
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
Flo, T. H., Smith, K. D., Sato, S., Rodriguez, D. J., Holmes, M. A., Strong, R. K., Akira, S., & Aderem, A. (2004) · Nature · doi:10.1038/nature03104 · Cited by 1,877 · see citing works
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828 · see citing works
Structure and signalling in the IL-17 receptor family
Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475 · see citing works
Self-citationTargeting IL-17 and TH17 cells in chronic inflammation
Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414 · see citing works
Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N., & Strong, R. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00708-6 · Cited by 1,355 · see citing works
Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., et al. (2011) · Science · doi:10.1126/science.1200439 · Cited by 1,056 · cited 1× · see citing works
“In agreement with the findings for mice, humans with mutations in IL-17RA or its ligand IL17F suffer from chronic mucocutaneous candidiasis (CMC), characterized by both OPC and dermal candidiasis (10).”
ResultConti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024 · see citing works
Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis
Leonardi, C. L., Matheson, R. T., Zachariae, C. O. C., Cameron, G. S., LI, L. C., Edson‐Heredia, E., Braun, D., & Banerjee, S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109997 · Cited by 933 · see citing works
Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
Papp, K. A., Leonardi, C. L., Menter, A., Ortonne, J. P., Krueger, J. G., Kricorian, G., Aras, G. A., Li, J., Russell, C. B., Thompson, E. H. Z., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1109017 · Cited by 932 · see citing works
Puel, A., Döffinger, R., Natividad, A., Chrabieh, M., Barcenas‐Morales, G., Pïcard, C., Cobat, A., Ouachée-Chardin, M., Toulon, A., Bustamante, J. C., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091983 · Cited by 730 · see citing works
A Cell-Surface Receptor for Lipocalin 24p3 Selectively Mediates Apoptosis and Iron Uptake
Devireddy, L. R., Gazin, C., Zhu, X., & Green, M. R. (2005) · Cell · doi:10.1016/j.cell.2005.10.027 · Cited by 672 · see citing works
Kisand, K. E., Wolff, A. S. B., Podkrajšek, K. T., Tserel, L., Link, M., Kisand, K., Ersvær, E., Perheentupa, J., Erichsen, M. M., Bratanič, N., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091669 · Cited by 672 · see citing works
An Iron Delivery Pathway Mediated by a Lipocalin
Yang, J., Goetz, D., Li, J.-Y., Wang, W., Mori, K., Setlik, D., Du, T., Erdjument-Bromage, H., Tempst, P., Strong, R., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00710-4 · Cited by 651 · see citing works
Raffatellu, M., George, M. D., Akiyama, Y., Hornsby, M. J., Nuccio, S.-P., Paixao, T. A., Butler, B. P., Chu, H., Santos, R. L., Berger, T., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.03.011 · Cited by 525 · see citing works
Berger, T., Togawa, A., Duncan, G. S., Elia, A. J., You-Ten, A., Wakeham, A., Fong, H. E. H., Cheung, C. C., & Mak, T. W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510847103 · Cited by 460 · see citing works
Devireddy, L. R., Teodoro, J. G., Richard, F. A., & Green, M. R. (2001) · Science · doi:10.1126/science.1061075 · Cited by 379 · see citing works
Th17 cells in immunity to Candida albicans
Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.008 · Cited by 361 · see citing works
Ford, A. C., & Peyrin‐Biroulet, L. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.138 · Cited by 342 · see citing works
Effect of IL-17A blockade with secukinumab in autoimmune diseases
Patel, D. D., Lee, D. M., Kolbinger, F., & Antoni, C. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202371 · Cited by 311 · see citing works
Identification of Common Transcriptional Regulatory Elements in Interleukin-17 Target Genes
Shen, F., Hu, Z., Goswami, J., & Gaffen, S. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604597200 · Cited by 294 · see citing works
Boisson, B., Wang, C., Pedergnana, V., Wu, L., Cypowyj, S., Rybojad, M., Belkadi, A., Picard, C., Abel, L., Fieschi, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.002 · Cited by 293 · see citing works
Shen, F., Ruddy, M. J., Plamondon, P., & Gaffen, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0904490 · Cited by 268 · see citing works
Self-citationHolmes, M. A., Paulsene, W., Jide, X., Ratledge, C., & Strong, R. K. (2005) · Structure · doi:10.1016/j.str.2004.10.009 · Cited by 246 · see citing works
Lipocalin 2 Is Required for Pulmonary Host Defense against Klebsiella Infection
Chan, Y. R., Liu, J. S., Pociask, D. A., Zheng, M., Mietzner, T. A., Berger, T., Mak, T. W., Clifton, M. C., Strong, R. K., Ray, P., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803282 · Cited by 220 · see citing works
Mouse model of oropharyngeal candidiasis
Solis, N. V., & Filler, S. G. (2012) · Nature Protocols · doi:10.1038/nprot.2012.011 · Cited by 195 · see citing works
Karlsen, J. R., Borregaard, N., & Cowland, J. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.017129 · Cited by 146 · see citing works
The Adaptor Protein CIKS/Act1 Is Essential for IL-25-Mediated Allergic Airway Inflammation
Claudio, E., Sønder, S. U., Saret, S., Carvalho, G., Ramalingam, T. R., Wynn, T. A., Chariot, A., García‐Pergañeda, A., Leonardi, A., Paun, A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.3.1617 · Cited by 142 · see citing works
Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy
Huppler, A. R., Bishu, S., & Gaffen, S. L. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3893 · Cited by 142 · see citing works
Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?
Puel, A., Pïcard, C., Cypowyj, S., Lilić, D., Abel, L., & Casanova, J. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.06.009 · Cited by 141 · see citing works
Candida-Host Interactions in HIV Disease
Fidel, P. L. (2011) · Advances in Dental Research · doi:10.1177/0022034511399284 · Cited by 128 · see citing works
Ho, A. W., Shen, F., Conti, H. R., Patel, N. M., Childs, E. E., Peterson, A., Hernández‐Santos, N., Kolls, J. K., Kane, L., Ouyang, W., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903739 · Cited by 124 · see citing works
The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases
Milner, J. D., & Holland, S. M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3493 · Cited by 98 · see citing works
Hu, C.-J., Bai, C., Zheng, X.-D., Wang, Y.-M., & Wang, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204545200 · Cited by 97 · see citing works
Development of vaccines for Candida albicans: fighting a skilled transformer
Cassone, A. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3156 · Cited by 93 · see citing works
Farah, C., Hu, Y., Riminton, S., & Ashman, R. (2006) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2006.00288.x · Cited by 82 · see citing works
Th17 cytokines and host-pathogen interactions at the mucosa: Dichotomies of help and harm
Liu, J. Z., Pezeshki, M., & Raffatellu, M. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.005 · Cited by 80 · see citing works
Lipocalin 2 Regulates Inflammation during Pulmonary Mycobacterial Infections
Guglani, L., Gopal, R., Rangel-Moreno, J., Junecko, B. F., Lin, Y., Berger, T., Mak, T. W., Alcorn, J. F., Randall, T. D., Reinhart, T. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050052 · Cited by 68 · see citing works
Liu, Z., Petersen, R., & Devireddy, L. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202411 · Cited by 64 · see citing works
Chronic mucocutaneous candidiasis and congenital susceptibility to Candida
Glocker, E. O., & Grimbacher, B. (2010) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32833fd74f · Cited by 63 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pathogenesis and virulence of Candida albicans
Lopes, J. P., & Lionakis, M. S. (2021) · Virulence · doi:10.1080/21505594.2021.2019950 · Cited by 511 · see citing works
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
Schinocca, C., Rizzo, C., Fasano, S., Grasso, G., Barbera, L. L., Ciccia, F., & Guggino, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.637829 · Cited by 370 · see citing works
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Interleukin-17A and Keratinocytes in Psoriasis
Furue, M., Furue, K., Tsuji, G., & Nakahara, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041275 · Cited by 311 · see citing works
IL-17–Mediated Immunity to the Opportunistic Fungal Pathogen <i>Candida albicans</i>
Conti, H. R., & Gaffen, S. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500909 · Cited by 301 · see citing works
Self-citationConti, H. R., Peterson, A. C., Brane, L., Huppler, A. R., Hernández-Santos, N., Whibley, N., Garg, A. V., Simpson-Abelson, M. R., Gibson, G. A., Mamo, A. J., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20130877 · Cited by 254 · see citing works
Self-citationThe Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Romejko, K., Markowska, M., & Niemczyk, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310470 · Cited by 264 · see citing works
Verma, A. H., Richardson, J., Zhou, C., Coleman, B. M., Moyes, D., Ho, J., Huppler, A., Ramani, K., McGeachy, M., Mufazalov, I., et al. (2017) · Science immunology · doi:10.1126/sciimmunol.aam8834 · Cited by 203 · see citing works
Conti, H. R., Bruno, V. M., Childs, E. E., Daugherty, S., Hunter, J. P., Mengesha, B. G., Saevig, D. L., Hendricks, M. R., Coleman, B. M., Brane, L., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.10.001 · Cited by 177 · see citing works
From the periphery to the brain: Lipocalin-2, a friend or foe?
Ferreira, A. C., Mesquita, S. D., Sousa, J. C., Correia‐Neves, M., Sousa, N., Palha, J. A., & Marques, F. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.06.005 · Cited by 174 · see citing works
Bai, F., Zheng, W. L., Dong, Y., Wang, J., Garstka, M. A., Li, R., An, J., & Ma, H. (2017) · Oncotarget · doi:10.18632/oncotarget.22260 · Cited by 171 · see citing works
Candida albicans–epithelial interactions and induction of mucosal innate immunity
Naglik, J. R., König, A., Hube, B., & Gaffen, S. L. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.10.030 · Cited by 165 · see citing works
Shao, S., Cao, T., Jin, L., Li, B., Fang, H., Zhang, J., Zhang, Y., Jin-hong, H., & Wang, G. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.03.002 · Cited by 145 · see citing works
Oral epithelial IL-22/STAT3 signaling licenses IL-17-mediated immunity to oral mucosal candidiasis
Aggor, F. E. Y., Break, T. J., Trevejo-Nuñez, G., Whibley, N., Coleman, B. M., Bailey, R. D., Kaplan, D. H., Naglik, J. R., Shan, W., Shetty, A. C., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aba0570 · Cited by 119 · see citing works
Self-citationIL-17-mediated antifungal defense in the oral mucosa is independent of neutrophils
Trautwein-Weidner, K., Gladiator, A., Nur, S., Diethelm, P., & Leibundgut-Landmann, S. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.57 · Cited by 116 · see citing works
Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections
Nasioudis, D., & Witkin, S. S. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0394-1 · Cited by 106 · see citing works
Inborn errors of immunity underlying fungal diseases in otherwise healthy individuals
Li, J., Vinh, D. C., Casanova, J., & Puel, A. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.10.016 · Cited by 103 · see citing works
IL-36 and IL-1/IL-17 drive immunity to oral candidiasis via parallel mechanisms
Verma, A. H., Zafar, H. M., Ponde, N., Hepworth, O. W., Sihra, D., Aggor, F. E. Y., Ainscough, J. S., Ho, J., Richardson, J., Coleman, B. M., et al. (2018) · Journal of Immunology · doi:10.4049/jimmunol.1800515 · Cited by 91 · see citing works
Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases
Dekens, D. W., Eisel, U. L. M., Gouweleeuw, L., Schoemaker, R. G., Deyn, P. P. D., & Naudé, P. J. W. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101414 · Cited by 93 · see citing works
Tristão, F. S. M., Rocha, F. A., Carlos, D., Ketelut-Carneiro, N., Souza, C. O. S., Milanezi, C. M., & Silva, J. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00949 · Cited by 87 · see citing works
Interleukin-17 in Antifungal Immunity
Sparber, F., & LeibundGut‐Landmann, S. (2019) · Pathogens · doi:10.3390/pathogens8020054 · Cited by 86 · see citing works
Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis
Whibley, N., Tritto, E., Traggiai, E., Kolbinger, F., Moulin, P., Brees, D., Coleman, B. M., Mamo, A. J., Garg, A. V., Jaycox, J. R., et al. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4a0915-428r · Cited by 65 · see citing works
Interleukin 17-Mediated Host Defense against Candida albicans
Sparber, F., & LeibundGut‐Landmann, S. (2015) · Pathogens · doi:10.3390/pathogens4030606 · Cited by 60 · see citing works
Lipocalin-2 is a pathogenic determinant and biomarker of neuropsychiatric lupus
Mike, E. V., Makinde, H. M., Gulinello, M. E., Vanarsa, K., Herlitz, L., Gadhvi, G. T., Winter, D. R., Mohan, C., Hanly, J. G., Mok, C. C., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.08.005 · Cited by 59 · see citing works
Conti, H. R., Whibley, N., Coleman, B. M., Garg, A. V., Jaycox, J. R., & Gaffen, S. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122807 · Cited by 57 · see citing works
Brothers in Arms: Th17 and Treg Responses in Candida albicans Immunity
Whibley, N., & Gaffen, S. L. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004456 · Cited by 58 · see citing works
Ling, Y., & Puel, A. (2014) · Actas Dermo-Sifiliográficas · doi:10.1016/s0001-7310(14)70016-x · Cited by 53 · see citing works
Navrazhina, K., Frew, J. W., Grand, D., Williams, S. C., Hur, H. B., Gonzalez, J., Garcet, S., & Krueger, J. G. (2022) · British Journal of Dermatology · doi:10.1111/bjd.21060 · Cited by 51 · see citing works
The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells
Lochner, M., Wang, Z., & Sparwasser, T. D. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.013 · Cited by 46 · see citing works
Mechanisms of Corticosteroid Resistance in Type 17 Asthma
Hong, L., Herjan, T., Bulek, K., Xiao, J., COMHAIR, S. A. A., ERZURUM, S. C., Li, X., & Liu, C. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200288 · Cited by 45 · see citing works
Gazendam, R. P., van de Geer, A., van Hamme, J. L., Tool, A. T. J., van Rees, D. J., Aarts, C. E. M., van den Biggelaar, M., van Alphen, F. P. J., Verkuijlen, P., Meijer, A. B., et al. (2016) · Haematologica · doi:10.3324/haematol.2015.136630 · Cited by 36 · see citing works
Break, T. J., Desai, J. V., Natarajan, M., Ferre, E. M. N., Henderson, C., Zelazny, A. M., Siebenlist, U., Hoekstra, W. J., Schotzinger, R. J., Garvey, E. P., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx352 · Cited by 34 · see citing works
Hathaway‐Schrader, J. D., Poulides, N. A., Carson, M. D., Kirkpatrick, J. E., Warner, A. J., Swanson, B. A., Taylor, E. V., Chew, M. E., Reddy, S. V., Liu, B., et al. (2020) · JBMR Plus · doi:10.1002/jbm4.10338 · Cited by 35 · see citing works
Recognition of Candida albicans and Role of Innate Type 17 Immunity in Oral Candidiasis
Pavlova, A. S., & Sharafutdinov, I. (2020) · Microorganisms · doi:10.3390/microorganisms8091340 · Cited by 32 · see citing works
Targeting Th17 cells: a promising strategy to treat oral mucosal inflammatory diseases
Wang, Y., Xue, N., Wang, Z., Zeng, X. Y., Ji, N., & Chen, Q. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1236856 · Cited by 32 · see citing works
Neutrophil Gelatinase-Associated Lipocalin Concentration in Vaginal Fluid
Beghini, J., Giraldo, P. C., Linhares, I. M., Ledger, W. J., & Witkin, S. S. (2015) · Reproductive Sciences · doi:10.1177/1933719115570914 · Cited by 30 · see citing works
Infections in the monogenic autoimmune syndrome APECED
Oikonomou, V., Break, T. J., Gaffen, S. L., Moutsopoulos, N. M., & Lionakis, M. S. (2021) · Current Opinion in Immunology · doi:10.1016/j.coi.2021.07.011 · Cited by 30 · see citing works
Shen, F., Verma, A. H., Volk, A. L., Jones, B. H., Coleman, B. M., Loza, M. J., Malaviya, R., Moore, B. A., Weinstock, D., Elloso, M. M., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801436 · Cited by 29 · see citing works
Oral lactoferrin protects against experimental candidiasis in mice
Velliyagounder, K., Alsaedi, W., Alabdulmohsen, W., Markowitz, K., & Fine, D. H. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12666 · Cited by 27 · see citing works
Zhao, G., Cheng, W.-Y., Wang, W., Jia, Y., Fang, Y.-Q., Du, S.-Z., & Yu, S.-K. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-212 · Cited by 27 · see citing works
Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis
Huppler, A. R., Verma, A. H., Conti, H. R., & Gaffen, S. L. (2015) · Pathogens · doi:10.3390/pathogens4030559 · Cited by 26 · see citing works
C/EBPβ Promotes Immunity to Oral Candidiasis through Regulation of β-Defensins
Simpson-Abelson, M. R., Childs, E. E., Ferreira, M. C., Bishu, S., Conti, H. R., & Gaffen, S. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136538 · Cited by 24 · see citing works
IκBζ is an essential mediator of immunity to oropharyngeal candidiasis
Taylor, T. C., Coleman, B. M., Arunkumar, S. P., Dey, I., Dillon, J. T., Ponde, N. O., Poholek, A. C., Schwartz, D. M., McGeachy, M. J., Conti, H. R., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.08.016 · Cited by 25 · see citing works
Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice
Tamaura, M., Satoh‐Takayama, N., Tsumura, M., Sasaki, T., Goda, S., Kageyama, T., Hayakawa, S., Kimura, S., Asano, T., Nakayama, M., et al. (2019) · International Immunology · doi:10.1093/intimm/dxz079 · Cited by 24 · see citing works
Clinical significance of Interleukin 17 receptor E in diabetic nephropathy
Wang, J., Wang, X., Wang, M., Wang, J., Wu, Y., & Qi, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110324 · Cited by 21 · see citing works
Wang, D., Fang, L., & Pan, G. (2019) · Disease Markers · doi:10.1155/2019/7361826 · Cited by 21 · see citing works
A gut-oral microbiome–driven axis controls oropharyngeal candidiasis through retinoic acid
Aggor, F. E. Y., Bertolini, M., Zhou, C., Taylor, T. C., Abbott, D. A., Musgrove, J., Bruno, V. M., Hand, T. W., & Gaffen, S. L. (2022) · JCI Insight · doi:10.1172/jci.insight.160348 · Cited by 20 · see citing works
Candida albicans Oropharyngeal Infection Is an Exception to Iron-Based Nutritional Immunity
Solis, N. V., Wakade, R. S., Filler, S. G., & Krysan, D. J. (2023) · mBio · doi:10.1128/mbio.00095-23 · Cited by 17 · see citing works
Nguyen, C. T. H., & Nguyen, O. P. T. (2022) · Dermatology Reports · doi:10.4081/dr.2022.9469 · Cited by 17 · see citing works
Colak, S., Omma, A., Sandıkçı, S. C., Yücel, Ç., Omma, T., & Turhan, T. (2019) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2019_010 · Cited by 17 · see citing works
Zhou, C., Monin, L., Gordon, R. A., Aggor, F. E. Y., Bechara, R., Edwards, T. N., Kaplan, D. H., Gingras, S., & Gaffen, S. L. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000394 · Cited by 14 · see citing works
Aşkun, T. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100869 · Cited by 15 · see citing works
Meyerhoff, N., Röhn, K., Carlson, R., & Tipold, A. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2019.00315 · Cited by 13 · see citing works
de Araújo, M. V., Santos, S. R. D., Nosanchuk, J. D., & Taborda, C. P. (2020) · Journal of Fungi · doi:10.3390/jof6040347 · Cited by 13 · see citing works
Constantinesco, N. J., Srikanth, S., Vito, L. D., Moras, C., Ramasubramanian, V., Chinnappan, B., Hartwick, S., Schwab, K. E., Wu, Y. L., & Gopal, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-61953-z · Cited by 10 · see citing works
Farzeen, I., Muzammil, S., Rafique, A., Noreen, R., Waseem, M., Andleeb, R., Ijaz, M. U., & Ashraf, A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.107900 · Cited by 10 · see citing works
Gong, J., Zhu, R., Gong, J., He, K., & Chen, J. (2017) · International Surgery Journal · doi:10.18203/2349-2902.isj20173376 · Cited by 6 · see citing works
Liu, S., Lin, K., Tian, Y., He, Y., Zhang, Z., Li, C., Luo, Y., Liang, Y., Ma, Y., & Deng, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114672 · Cited by 5 · see citing works
Altmeier, S., & LeibundGut‐Landmann, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-50842-9_2 · Cited by 5 · see citing works
Dermatoses of the Oral Cavity and Lips
Scully, C. M. (2016) · Wiley eBooks · doi:10.1002/9781118441213.rtd0111 · Cited by 4 · see citing works
Implications of innate lymphoid cells in oral diseases.
Hu, S.-T., Zhou, G., & Zhang, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112122 · Cited by 2 · see citing works
Zhang, J., Li, W., Huo, S., Xin, X., & Wang, L. (2025) · Poultry Science · doi:10.1016/j.psj.2025.105247 · Cited by 2 · see citing works
Yazkova, O. S., & Anpilogova, E. M. (2022) · Russian Journal of Skin and Venereal Diseases · doi:10.17816/dv105476 · Cited by 1 · see citing works
Omma, A., Erden, F., Çolak, S. Y., Sandıkçı, S. C., Omma, T., Kasım, İ., Özkara, A., & Erden, A. (2024) · Ulusal Romatoloji Dergisi · doi:10.4274/raed.galenos.2024.83097 · Cited by 1 · see citing works
Garazha, S. N., Гришилова, Е. Н., Garazha, I., Nekrasova, E. F., Hubaeva, F., Ильина, Е. Е., & Hubaev, T. S.-S. (2020) · Russian Journal of Dentistry · doi:10.17816/1728-2802-2020-24-5-332-336 · Cited by 1 · see citing works
Impact of polycystic ovary syndrome on methyl group metabolism
Bries, A. E. (2020) · doi:10.31274/etd-20210114-18 · Cited by 1 · see citing works
Association of Interleukin 17 in Antifungal Insusceptibility: The Systematic Review and Metaanalysis
Dabukke, Y. J. S. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs221611210
Rivera, A. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732070802.793538562
Santos, S. R. D. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2022.tde-22062023-154055
Ponde, N. O., Cook, M. E., Mehta, I., Dey, I., Yamamoto, K., Taylor, T. C., Coleman, B. M., Vyas, S. P., Bechara, R., Das, J., et al. (2025) · bioRxiv · doi:10.1101/2025.09.07.674635
Deng, W., Chen, Y., Liu, S., Liu, S., Zhang, K., Wang, D., Yu, Z., Zhao, W., Xu, Y., Wang, X., et al. (2026) · Immunity & Inflammation · doi:10.1007/s44466-026-00041-5 · Cited by 1 · see citing works
- Authors
- Ferreira, M. C., Whibley, N., Mamo, A. J., Siebenlist, U., Chan, Y. R., & Gaffen, S. L.
- Affiliations
- University of Pittsburgh (US)
- National Institutes of Health (US)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2014-03
- Volume
- 82
- Issue
- 3
- Pages
- 1030-1035
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC3958007
- OpenAlex
- W2134545706
- Cited by
- 72
- References
- 40
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 2 · 2017: 9 · 2016: 5 · 2015: 10 · 2014: 6
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5r37de022550-12)
- Genentech
- National Institute of Allergy and Infectious Diseases
- National Institute of Dental and Craniofacial Research (R37-DE022550, R01DE022550, R01DE023815, DE022550, DE023815)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- neutrophil gelatinase-associated lipocalin, IL-17, oropharyngeal candidiasis, Candida albicans, antifungal immunity, Th17 cells, IL-17RA, Act1, iron acquisition, siderophores, mucosal candidiasis, steroid immunosuppression, CD4+ T cells
- MeSH terms
- Lipocalin-2, Acute-Phase Proteins, Animals, Candida albicans, Candidiasis, Oral, Mice, Inbred C57BL, Mouth Mucosa, Mucous Membrane, Oncogene Proteins, Up-Regulation, Interleukin-17, Mice, Receptors, Interleukin-17, Lipocalins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
