Cited by 301Antifungal resistance and susceptibilityIL-33, ST2, and ILC PathwaysPsoriasis: Treatment and Pathogenesis

IL-17–Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans

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Conti, Heather R, Gaffen, Sarah L·2015·The Journal of Immunology

Abstract

IL-17 (IL-17A) has emerged as a key mediator of protection against extracellular microbes, but this cytokine also drives pathology in various autoimmune diseases. Overwhelming data in both humans and mice reveal a clear and surprisingly specific role for IL-17 in protection against the fungus Candida albicans, a commensal microbe of the human oral cavity, gastrointestinal tract, and reproductive mucosa. The IL-17 pathway regulates antifungal immunity through upregulation of proinflammatory cytokines, including IL-6, neutrophil-recruiting chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides (e.g., defensins), which act in concert to limit fungal overgrowth. This review focuses on diseases caused by C. albicans, the role of IL-17–mediated immunity in candidiasis, and the implications for clinical therapies for both autoimmune conditions and fungal infections.

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  1. [43]Gaffen SL Jain R Garg A Cua D IL-23-IL-17 immune axis: Discovery, mechanistic understanding and clinical therapy Nat Rev Immunol 2014 14 585 600 25145755 PMC4281037
  2. [76]Moyes DL Runglall M Murciano C Shen C Nayar D Thavaraj S Kohli A Islam A Mora-Montes H Challacombe SJ Naglik JR A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells Cell Host Microbe 2010 8 225 235 20833374 PMC2991069

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Authors
Conti, H. R., & Gaffen, S. L.
Affiliations
University of Pittsburgh (US)
Corresponding author
Gaffen, Sarah L
Venue
The Journal of Immunology
Published
2015-08-01
Volume
195
Issue
3
Pages
780-788
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W1912289137
Cited by
301
References
129
Citations by year
2026: 28 · 2025: 29 · 2024: 20 · 2023: 19 · 2022: 35 · 2021: 26 · 2020: 35 · 2019: 28 · 2018: 34 · 2017: 22 · 2016: 22 · 2015: 2 · 2014: 1
FWCI
4.05
Type
journal article
Language
en
Open access
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5r37de022550-12, DE022550)
  • National Institute of Allergy and Infectious Diseases (R01AI107825, AI107825)
  • National Institute of Dental and Craniofacial Research (R37-DE022550, F32DE023293, R01DE022550, R01DE023815, DE022550)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
IL-17, IL-17A, Candida albicans, antifungal immunity, candidiasis, opportunistic fungal infection, neutrophil recruitment, CXCL1, CXCL5, antimicrobial peptides, defensins, interleukin-6, inflammatory cytokines, autoimmune disease, fungal overgrowth
MeSH terms
Animals, Candida albicans, Candidiasis, Humans, Neutrophils, Opportunistic Infections, Signal Transduction, Interleukin-6, Interleukin-17, Neutrophil Infiltration, Defensins, Receptors, Pattern Recognition, Mice, Receptors, Interleukin-17, Chemokine CXCL1, Chemokine CXCL5

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