Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 Immunity
Open accessAbstract
Chronic yeast infections in the absence of other infections result from genetic deficiencies in proinflammatory host responses.
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IL-17-mediated immunity is central to mucocutaneous host defense against fungi such as C. albicans and Malassezia.
“IL-17-mediated immunity is central to mucocutaneous host defense against fungi such as C. albicans and Malassezia [10,99,100].”
From Host–Candida auris interactions in the skin (2026) · cites this paper as [99]
The Abstract states that human IL-17A and IL-17F are essential for mucocutaneous immunity against C. albicans. A search for Malassezia found no passage addressing that fungus, so the source supports only the C. albicans part of the claim. (LLM, conf=0.88)
Experimental — accuracy not yet measuredTh17 cells in different tissue sites can show distinct transcriptional profiles associated with homeostatic or pathogenic functions.
“analysis of Th17 cells in different tissue sites has revealed that Th17 cells may exhibit distinct transcriptional profiles associated with either homeostatic or pathogenic functions”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
SFB-specific intestinal homeostatic Th17 cells have a transcriptome that differs markedly from pro-inflammatory Th17 cells elicited by H. hepaticus in mice defective for induced intestinal Treg cells.
“intestinal non-pathogenic/homeostatic Th17 cells specific for segmented filamentous bacteria (SFB) have a transcriptome that differs markedly from the pro-inflammatory Th17 cells elicited by Helicobacter hepaticus (H. hepaticus) in mice defective for induced intestinal Treg cells”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
In the Il10−/− model of colitis, Th17 cells are the main immune population mediating the inflammatory response.
“In the Il10−/− model of colitis, in which IL-10-deficient mice develop spontaneous microbiota-dependent colitis, Th17 cells were identified as the main immune population mediating the inflammatory immune response [43, 133].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
In Helicobacter hepaticus-dependent colitis, pathobiont-specific inflammatory Th17 cells are major mediators of intestinal inflammation.
“In Helicobacter hepaticus- dependent colitis, pathobiont-specific inflammatory Th17 cells are major mediators of intestinal inflammation [43].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [43]
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“aureus skin infections, were found to have autoantibodies specific for the T H 17 cell cytokines IL-17A, IL-17F and IL-22, as well as mutations in the genes encoding IL-17F and IL-17 receptor A (IL-17RA”
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Tissue-Specific Immunity at the Oral Mucosal Barrier
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“Elegant studies in animal models, as well as examination of patients with genetic defects in IL-17-signaling and Th17 differentiation, have revealed a vital role for IL-17 in oral anti-fungal immunity [15] [16].”
BackgroundThe dichotomous nature of T helper 17 cells
Stockinger, B., & Omenetti, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.50 · Cited by 399 · see citing works
IL-17 in Chronic Inflammation: From Discovery to Targeting
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Deep Dermatophytosis and Inherited CARD9 Deficiency
Lanternier, F., Pathan, S., Vincent, Q. B., Liu, L., Cypowyj, S., Prando, C., Migaud, M., Taibi, L., Ammar-Khodja, A., Stambouli, O. B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1208487 · Cited by 394 · see citing works
Self-citationThe IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside
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IL-17A is essential for cell activation and inflammatory gene circuits in subjects with psoriasis
Krueger, J. G., Fretzin, S., Suárez‐Fariñas, M., Haslett, P. A. J., Phipps, K. M., Cameron, G. S., McColm, J., Katcherian, A., Cueto, I., White, T. R., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.04.024 · Cited by 383 · see citing works
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“Specifically, patients with primary immunodeficiencies affecting either TH17 cell differentiation or function (12, 13) all have susceptibility to oral candidiasis.”
Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense
Osorio, F., & Sousa, C. R. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.001 · Cited by 377 · see citing works
CD4 T Helper Cell Subsets and Related Human Immunological Disorders
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“It has also been reported that two different genetic etiologies of chronic mucocutaneous candidiasis diseases are associated with autosomal recessive deficiency in the cytokine receptor IL-17RA and autosomal dominant deficiency in IL-17F, respectively [157].”
BackgroundImmune responses to human fungal pathogens and therapeutic prospects
Lionakis, M. S., Drummond, R. A., & Hohl, T. M. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00826-w · Cited by 379 · see citing works
Th17 cells in immunity to Candida albicans
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“il17f in humans are linked to CMC, although the mutations affect IL-17A as well as IL-17F signaling (Puel et al., 2011).”
InfluentialHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
Kreins, A. Y., Ciancanelli, M. J., Okada, S., Kong, X., Ramirez‐Alejo, N., Kılıç, S. Ş., Baghdadi, J. E., Nonoyama, S., Mahdaviani, S. A., Ailal, F., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20140280 · Cited by 364 · see citing works
“CMC and impaired IL-17 T cell development occur in no more than 30% of IL-12R1– deficient patients, although all display abrogated responses to IL-23 (de Beaucoudrey et al., 2008; Ma et al., 2008; Liu et al., 2011; Puel et al., 2011; Ouederni et al., 2014).”
BackgroundSelf-citationInterleukin-17 and innate immunity in infections and chronic inflammation
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“Autosomal recessive IL-17RA and autosomal dominant IL-17F deficiencies have been reported in chronic mucocutaneous candidiasis (CMC) patients [131].”
BackgroundDevelopment of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave
Haas, J. D., Ravens, S., Düber, S., Sandrock, I., Oberdörfer, L., Kashani, E., Chennupati, V., Föhse, L., Naumann, R., Weiss, S., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.003 · Cited by 348 · see citing works
“In humans, it is currently emerging that the cytokines IL-17A and IL-17F are particularly important for control of mucocutaneous infections because their absence or mutations in their signaling pathway lead to chronic mucocutaneous candidiasis (Puel et al., 2011; van de Veerdonk et al., 2011).”
The multitasking organ: recent insights into skin immune function.
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Heterogeneity of Human CD4 <sup>+</sup> T Cells Against Microbes
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“This discovery was followed by the striking finding that patients with chronic mucocutaneous candidiasis lacked functional Th17 cells, owing to deletions or mutations in genes involved in Th17 differentiation or function, such as STAT3 (94–96), IL17RA, IL17RC, or IL17F (97, 98).”
Backgroundd’Enfert, C., Kaune, A.-K., Alaban, L. R., Chakraborty, S., Cole, N. L., Delavy, M., Kosmala, D., Marsaux, B., Fróis-Martins, R., Morelli, M., et al. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa060 · Cited by 351 · see citing works
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“albicans infects mucosal and epidermal surfaces, causing mucocutaneous candidiasis, or disseminates into the bloodstream, causing life-threatening systemic candidiasis (Plantinga et al., 2012; Puel et al., 2011).”
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“Importantly, defects in the IL-17/IL-23 axis render the host exquisitely susceptible to CMC, highlighting the importance of this pathway in controlling C. albicans infections.”
BackgroundInfluentialAutosomal Dominant STAT3 Deficiency and Hyper-IgE Syndrome
Chandesris, M., Melki, I., Natividad, A., Puel, A., Fieschi, C., Ling, Y., Thumerelle, C., Oksenhendler, É., Boutboul, D., Thomas, C., et al. (2012) · Medicine · doi:10.1097/md.0b013e31825f95b9 · Cited by 338 · see citing works
“[56-58] Moreover, we recently found gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis.”
BackgroundSelf-citationInterleukin 17A: Toward a new understanding of psoriasis pathogenesis
Lynde, C. W., Poulin, Y. P., Vender, R. B., Bourcier, M., & Khalil, S. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.12.036 · Cited by 337 · see citing works
IL‐17 and IL‐22 in immunity: Driving protection and pathology
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Primary Immunodeficiency Diseases Worldwide: More Common than Generally Thought
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“This is the case for predisposition to invasive pneumococcal diseases [11], Herpes simplex encephalitis [14] and chronic mucocutaneous candidiasis [15].”
BackgroundSelf-citationInborn Errors of Human JAKs and STATs
Casanova, J., Holland, S. M., & Notarangelo, L. D. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.016 · Cited by 320 · see citing works
“…also display various autoimmune and allergic signs, including autoimmune thyroiditis, idiopathic thrombocytopenic purpura, lymphocytic interstitial pneumonitis, and severe eczema (Kofoed et al., 2003; Nadeau et al., 2011; Bernasconi et al., 2006; Hwa et al., 2011; Pugliese-Pires et al., 2010).”
Self-citationEarly and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., Adelmann, K., Kang, Y.-H., Fergusson, J. R., Peter Simmonds, K., et al. (2012) · Blood · doi:10.1182/blood-2012-06-436436 · Cited by 310 · see citing works
Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines
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Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis
Puel, A., Cypowyj, S., Maródi, L., Abel, L., Pïcard, C., & Casanova, J. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e328358cc0b · Cited by 310 · see citing works
Self-citationEffect of IL-17A blockade with secukinumab in autoimmune diseases
Patel, D. D., Lee, D. M., Kolbinger, F., & Antoni, C. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202371 · Cited by 311 · see citing works
“The relevance of IL-17 in host defence has been demonstrated in recent genetic studies of subjects with chronic mucocutaneous candidiasis disease.(12) In this syndrome characterised by recurrent or persistent infections (predominantly with Candida albicans or to a lesser extent Staphylococcus aureus) of the mucosae, n…”
BackgroundBlauvelt, A., Reich, K., Tsai, T., Tyring, S. K., Vanaclocha, F., Kingo, K., Ziv, M., Pinter, A., Vender, R. B., Hugot, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.08.008 · Cited by 311 · see citing works
Cytokines as Therapeutic Targets in Rheumatoid Arthritis and Other Inflammatory Diseases
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“Individuals with genetic deficiencies in IL-17A and IL-17F are prone to chronic mucocutaneous candidiasis and possibly Staphylococcus aureus (Puel et al., 2011).”
BackgroundInterleukin-17A and Keratinocytes in Psoriasis
Furue, M., Furue, K., Tsuji, G., & Nakahara, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041275 · Cited by 311 · see citing works
IL-17–Mediated Immunity to the Opportunistic Fungal Pathogen <i>Candida albicans</i>
Conti, H. R., & Gaffen, S. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500909 · Cited by 301 · see citing works
“family with autosomal dominant CMC (114).”
Backgroundvan de Kerkhof, P. C. M., Griffiths, C. E. M., Reich, K., Leonardi, C. L., Blauvelt, A., Tsai, T., Gong, Y., Huang, J., Papavassilis, C., & Fox, T. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.03.024 · Cited by 301 · see citing works
Bastard, P., Orlova, E., Sozaeva, L., Lévy, R., James, A. E., Schmitt, M. M., Ochoa, S., Kareva, M., Rodina, Y. A., Gervais, A., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210554 · Cited by 299 · see citing works
“Among these anti-cytokine auto-Abs, neutralizing auto-Abs against IL-17A and IL-17F phenocopy inborn errors of IL-17A/F and underlie chronicmucocutaneous candidiasis (CMC; Kisand et al., 2010; Puel et al., 2011; Puel et al., 2010).”
BackgroundSelf-citationThe role of Dectin-1 in the host defence against fungal infections
Drummond, R. A., & Brown, G. D. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.07.001 · Cited by 294 · see citing works
“CMC, Hyper IgE Syndrome, APECED) [51,52] show an increased susceptibility to mucosal candidiasis.”
BackgroundBoisson, B., Wang, C., Pedergnana, V., Wu, L., Cypowyj, S., Rybojad, M., Belkadi, A., Picard, C., Abel, L., Fieschi, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.002 · Cited by 293 · see citing works
“The IL17RA / fibroblasts used have been described elsewhere (Puel et al., 2011).”
InfluentialSelf-citationTH17 cell heterogeneity and its role in tissue inflammation
Schnell, A., Littman, D. R., & Kuchroo, V. K. (2023) · Nature Immunology · doi:10.1038/s41590-022-01387-9 · Cited by 286 · see citing works
Boisson‐Dupuis, S., Kong, X., Okada, S., Cypowyj, S., Puel, A., Abel, L., & Casanova, J. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.011 · Cited by 287 · see citing works
Self-citationLoss of ceramide synthase 3 causes lethal skin barrier disruption
Jennemann, R., Rabionet, M., Gorgas, K., Epstein, S., Dalpke, A. H., Rothermel, U., Bayerle, A., van der Hoeven, F., Imgrund, S., Kirsch, J., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr494 · Cited by 283 · see citing works
“chronic mucocutaneous candidiasis disease, for which in most cases the underlying etiology is still unknown (56,57), offers a potential linkage to the CERS3 gene.”
BackgroundA cellular and molecular view of T helper 17 cell plasticity in autoimmunity
Stadhouders, R., Lubberts, E., & Hendriks, R. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.007 · Cited by 289 · see citing works
Recent advances in the IL-17 cytokine family
Gaffen, S. L. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.006 · Cited by 283 · see citing works
Th17 Cells in Immunity and Autoimmunity
Bedoya, S. K., Lam, B. K., Lau, K., & Larkin, J. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/986789 · Cited by 278 · see citing works
“[142] A.”
BackgroundSiegel, A., Heimall, J. R., Freeman, A. F., Hsu, A. P., Brittain, E., Brenchley, J. M., Douek, D. C., Fahle, G. H., Cohen, J. I., Holland, S. M., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.016 · Cited by 275 · see citing works
“, 2006), or Th17 cell defects (Ferwerda et al., 2009; Glocker et al., 2009; Puel et al., 2011) are not associated with abnormal VZV or EBV responses, arguing against a role for those defects that are normally observed in AD-HIES as a cause for the diminished capacity to control chronic viruses.”
BackgroundHuman inborn errors of immunity: An expanding universe
Notarangelo, L. D., Bacchetta, R., Casanova, J., & Su, H. C. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb1662 · Cited by 279 · see citing works
“Overall, core molecular deficiencies of these three groups of patients with HIES involve an impaired ZNF341-and STAT3-dependent IL-6 signal transducer (IL-6ST)–mediated response to IL-6 (allergy and staphylococcal disease) and IL-11 (skeletal anomalies), whereas at least some specific features, such as CMC, are caused…”
BackgroundInfluentialSelf-citationInvasive fungal infection and impaired neutrophil killing in human CARD9 deficiency
Drewniak, A., Gazendam, R. P., Tool, A. T. J., van Houdt, M., Jansen, M. H., van Hamme, J. L., van Leeuwen, E. M. M., Roos, D., Scalais, E., de Beaufort, C. E., et al. (2013) · Blood · doi:10.1182/blood-2012-08-450551 · Cited by 276 · see citing works
“The role of IL-17 in the defense against persistent Candida infection has been directly implicated by the identification of IL-17R and IL-17F mutations in pedigrees suffering from chronic mucocutaneous candidiasis (CMC).(4,5) On the other hand, the innate complement and phagocyte pathways of host immunity against Cand…”
BackgroundCandida albicans interactions with epithelial cells and mucosal immunity
Naglik, J. R., Moyes, D. L., Wächtler, B., & Hube, B. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.06.009 · Cited by 277 · see citing works
Braun, J., Baraliakos, X., Deodhar, A. A., Baeten, D., Sieper, J., Emery, P., Readie, A., Martin, R., Mpofu, S., & Richards, H. B. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-209730 · Cited by 273 · see citing works
Interleukin-17 in chronic inflammatory neurological diseases
Milovanovic, J., Arsenijevic, A., Stojanovic, B., Kanjevac, T., Arsenijevic, D., Radosavljevic, G., Milovanovic, M., & Arsenijevic, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00947 · Cited by 250 · see citing works
“In humans, mutations in IL-17 signaling genes (ACT1, IL17RA, IL17RC) are associated with chronic mucocutaneous candidiasis (5, 7, 8).”
BackgroundGuidelines for genetic studies in single patients: lessons from primary immunodeficiencies
Casanova, J., Conley, M. E., Seligman, S. J., Abel, L., & Notarangelo, L. D. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140520 · Cited by 255 · see citing works
Self-citationMcGonagle, D., McInnes, I. B., Kirkham, B. W., Sherlock, J. P., & Moots, R. J. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215356 · Cited by 258 · see citing works
Interplay between Candida albicans and the mammalian innate host defense
Cheng, S.-C., Joosten, L. A. B., Kullberg, B.-J., & Netea, M. G. (2012) · Infection and Immunity · doi:10.1128/iai.06146-11 · Cited by 256 · see citing works
“Another line of evidence on the role of Th17 for antifungal defense as well as for the occurrence of chronic mucocutaneous candidiasis in patients with IL-17F or IL-17 receptor deficiencies comes from the dectin-1/CARD9/ Th17 pathway (89).”
BackgroundConti, H. R., Peterson, A. C., Brane, L., Huppler, A. R., Hernández-Santos, N., Whibley, N., Garg, A. V., Simpson-Abelson, M. R., Gibson, G. A., Mamo, A. J., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20130877 · Cited by 254 · see citing works
Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity
Gaffen, S., & Moutsopoulos, N. (2020) · Science immunology · doi:10.1126/sciimmunol.aau4594 · Cited by 230 · see citing works
Brown, A. F., Leech, J. M., Rogers, T. R., & McLoughlin, R. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00507 · Cited by 247 · see citing works
“Inborn errors of Th17 cells seem to underlie CMC (209, 210).”
BackgroundKirkham, B. W., Kavanaugh, A., & Reich, K. (2013) · Immunology · doi:10.1111/imm.12142 · Cited by 243 · see citing works
Old and New Biological Therapies for Psoriasis
Rønholt, K., & Iversen, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112297 · Cited by 240 · see citing works
“Manageable mucocutaneous candida infection is associated with all the IL-17 inhibitors, which is probably due to the key role of IL-17 in the host defense against fungi [127,128].”
BackgroundMiller, L. S., Fowler, V. G., Shukla, S. K., Rose, W. E., & Proctor, R. A. (2019) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuz030 · Cited by 237 · see citing works
“aureus skin infections rather than host defense against bacteremia (Cho et al. 2010; Puel et al. 2011; Montgomery et al. 2014; Chan et al. 2015; Marchitto et al. 2019).”
BackgroundHoefs, S., Mogavero, S., & Hube, B. (2016) · The Journal of Microbiology · doi:10.1007/s12275-016-5514-0 · Cited by 238 · see citing works
“observed in patients exhibiting an autosomal recessive deficiency in the IL-17 cytokine receptor IL-17RA, and autosomal dominant deficiency of IL-17F (Puel et al., 2011).”
BackgroundInfluentialChemin, K., Gerstner, C., & Malmström, V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00353 · Cited by 235 · see citing works
“Th17 cells are particularly important in protective immunity against fungal and extracellular bacterial infections (Staphylococcus aureus) (58).”
BackgroundCho, J. S., Guo, Y., Ramos, R. I., Hebroni, F., Plaisier, S. B., Xuan, C., Granick, J. L., Matsushima, H., Takashima, A., Iwakura, Y., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003047 · Cited by 233 · see citing works
“aureus in various mouse models of infection (cutaneous infection, systemic infections, pneumonia and brain abscesses [52– 56]) as well as in humans with hyper-IgE syndrome or with a deficiency in IL-17F or IL-17RA [50,57–60].”
Background
- Authors
- Puel, A., Cypowyj, S., Bustamante, J., Wright, J. F., Liu, L., Lim, H. K., Migaud, M., Israel, L., Chrabieh, M., Audry, M., Gumbleton, M., Toulon, A., Bodemer, C., El-Baghdadi, J., Whitters, M., Paradis, T., Brooks, J., Collins, M., Wolfman, N. M., Al-Muhsen, S., Galicchio, M., Abel, L., Picard, C., & Casanova, J.-L.
- Affiliations
- Inserm (FR)
- Rockefeller University (US)
- Pfizer (United States) (US)
- Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, U980, and University Paris Descartes, Necker Medical School, 75015 Paris, France.
- SUNY Upstate Medical University (US)
- Hôpital Necker-Enfants Malades (FR)
- Unit of Genetics, Military Hospital of Instruction Mohamed V, Rabat 10000, Morocco.
- Prince Naif Center for Immunology Research, Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
- Victor J. Vilela Children’s Hospital, Rosario, Santa Fe 2000, Argentina.
- Corresponding author
- Puel, Anne
- Cypowyj, Sophie
- Abel, Laurent
- Casanova, Jean-Laurent
- ORCID
- Venue
- Science
- Published
- 2011-04
- Volume
- 332
- Issue
- 6025
- Pages
- 65-68
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3070042
- OpenAlex
- W2034453891
- Cited by
- 1,056
- References
- 30
- Citations by year
- 2026: 26 · 2025: 35 · 2024: 29 · 2023: 54 · 2022: 52 · 2021: 64 · 2020: 76 · 2019: 57 · 2018: 67 · 2017: 84 · 2016: 81 · 2015: 76 · 2014: 94 · 2013: 95 · 2012: 103
- FWCI
- 49.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Center for Research Resources (UL1RR024143)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- chronic mucocutaneous candidiasis, IL-17A, Candida albicans, primary immunodeficiency, autosomal recessive inheritance, autosomal dominant inheritance
- MeSH terms
- Candida albicans, Candidiasis, Chronic Mucocutaneous, Child, Child, Preschool, Female, Genes, Dominant, Genes, Recessive, Humans, Male, Molecular Sequence Data, Mutation, Pedigree, Signal Transduction, Interleukin-17, Receptors, Interleukin-17, Th17 Cells
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