The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Adenovirus infection enhances in vitro adherence of Streptococcus pneumoniae.
Open accessAbstract
Viruses are thought to facilitate bacterial infections of the respiratory tract, but the mechanisms are poorly understood. The present study analyzed the effect of adenovirus on bacterial adherence to human respiratory tract epithelial cells. The human lung carcinoma cell line A549 was infected with adenovirus of types 1, 2, 3, 4, 5, and 9. At a multiplicity of infection of 75 particles per cell, cytopathic effects occurred in 75 to 100% of the cells within 48 h. The virus-infected cells were harvested at various times after infection and analyzed for the ability to bind strains of Haemophilus influenzae and Streptococcus pneumoniae. Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. This effect was not seen for other adenovirus types. Adenovirus infection did not change the adherence of cells of poorly adhering strains of S. pneumoniae or H. influenzae. The increase in adherence of S. pneumoniae could be inhibited by the DNA synthesis inhibitor cytosine arabinofuranoside, which is known to block the late phase of the adenovirus infection. When electron microscopy was used, there was no evidence that virus particles bound directly to bacteria. Adherence was not affected by pretreatment of the cells with virus particles or viral proteins. This suggested that adenovirus infection upregulated receptors for S. pneumoniae. The increased attachment may be one mechanism by which viruses precondition the respiratory mucosa for bacterial infection.
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Metadata
- Authors
- Håkansson, A., Kidd, A., Wadell, G., Sabharwal, H., & Svanborg, C.
- Affiliations
- Lund University (SE)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1994-07
- Volume
- 62
- Issue
- 7
- Pages
- 2707-2714
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC302872
- OpenAlex
- W2042417907
- Cited by
- 134
- References
- 35
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 13 · 2013: 5 · 2012: 4
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- adenovirus, Streptococcus pneumoniae, bacterial adhesion, Haemophilus influenzae, respiratory infections, viral-bacterial interactions, airway epithelial cells, A549 cells, cytosine arabinofuranoside, cytopathic effect
- MeSH terms
- Adenoviridae, Adenoviridae Infections, Bacterial Adhesion, Capsid, Cells, Cultured, Cytarabine, Epithelium, Humans, Nasopharynx, Pneumococcal Infections, Streptococcus pneumoniae, Virus Replication, Capsid Proteins
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