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Helicobacter pylori Uses Motility for Initial Colonization and To Attain Robust Infection
Open accessAbstract
Helicobacter pylori has been shown to require flagella for infection of the stomach. To analyze whether flagella themselves or motility is needed by these pathogens, we constructed flagellated nonmotile mutants. This was accomplished by using both an insertion mutant and an in-frame deletion of the motB gene. In vitro, these mutants retain flagella (Fla + ) but are nonmotile (Mot − ). By using FVB/N mice, we found that these mutants had reduced ability to infect mice in comparison to that of their isogenic wild-type counterparts. When these mutants were coinfected with wild type, we were unable to detect any motB mutant. Finally, by analyzing the 50% infectious dose, we found that motility is needed for initial colonization of the stomach mucosa. These results support a model in which motility is used for the initial colonization of the stomach and also to attain full infection levels.
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Cites
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
Alm, R. A., Ling, L.-S. L., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., et al. (1999) · Nature · doi:10.1038/16495 · Cited by 1,893
Cited by
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
Bartfeld, S., Bayram, T., van de Wetering, M., Huch, M., Begthel, H., Kujala, P., Vries, R., Peters, P. J., & Clevers, H. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.09.042 · Cited by 820
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
Dempsey, E., & Corr, S. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.840245 · Cited by 579
Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568
Pérez-Rodríguez, I., Bolognini, M., Ricci, J., Bini, E., & Vetriani, C. (2015) · The ISME Journal · doi:10.1038/ismej.2014.214 · Cited by 44
Le Bloa, S., Durand, L., Cueff- Gauchard, V., Le Bars, J., Taupin, L., Marteau, C., Bazire, A., & Cambon-Bonavita, M.-A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174338 · Cited by 12
Assembly and glycosylation of Helicobacter pylori sheathed flagella
Kumar, R., Tachiyama, S., Yu, H., Heydari, S., Guo, J., Botting, J. M., Guo, W., Hoover, T. R., & Liu, J. (2026) · PNAS Nexus · doi:10.1093/pnasnexus/pgag011 · Cited by 6
Lopez-Magaña, R., & Ottemann, K. M. (2026) · Journal of Bacteriology · doi:10.1128/jb.00394-25 · Cited by 1
Self-citation
Metadata
- Authors
- Ottemann, K. M., & Lowenthal, A. C.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2002-04
- Volume
- 70
- Issue
- 4
- Pages
- 1984-1990
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2129012692
- Cited by
- 326
- References
- 2
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- green
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