Cited by 121Fungal and yeast genetics researchAntifungal resistance and susceptibilityFungal Infections and Studies

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Calcineurin Is Essential for Virulence in Candida albicans

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Bader, Teresa, Bodendorfer, Barbara, Schröppel, Klaus, Morschhäuser, Joachim·2003·Infection and Immunity

DOI 10.1128/iai.71.9.5344-5354.2003PMC PMC187310

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Abstract

Calcineurin is a conserved Ca 2+ -calmodulin-activated, serine/threonine-specific protein phosphatase that regulates a variety of physiological processes, e.g., cell cycle progression, polarized growth, and adaptation to salt and alkaline pH stresses. In the pathogenic yeast Cryptococcus neoformans , calcineurin is also essential for growth at 37°C and virulence. To investigate whether calcineurin plays a role in the virulence of Candida albicans , the major fungal pathogen of humans, we constructed C. albicans mutants in which both alleles of the CMP1 gene, encoding the calcineurin catalytic subunit, were deleted. The C. albicans Δ cmp1 mutants displayed hypersensitivity to elevated Na + , Li + , and Mn 2+ concentrations and to alkaline pH, phenotypes that have been described after calcineurin inactivation in the related yeast Saccharomyces cerevisiae . Unlike S. cerevisiae calcineurin mutants, which exhibit reduced susceptibility to high Ca 2+ concentrations, growth of C. albicans was inhibited in the presence of 300 mM CaCl 2 after the deletion of CMP1 , demonstrating that there are also differences in calcineurin-mediated cellular responses between these two yeast species. In contrast to C. neoformans , inactivation of calcineurin did not cause temperature sensitivity in C. albicans . In addition, hyphal growth, an important virulence attribute of C. albicans , was not impaired in the Δ cmp1 mutants under a variety of inducing conditions. Nevertheless, the virulence of the mutants was strongly attenuated in a mouse model of systemic candidiasis, demonstrating that calcineurin signaling is essential for virulence in C. albicans .

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
The mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695
Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
Gillum, A. M., Tsay, E. Y. H., & Kirsch, D. R. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00328721 · Cited by 1,253
Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS
Gimeno, C. J., Ljungdahl, P. O., Styles, C. A., & Fink, G. R. (1992) · Cell · doi:10.1016/0092-8674(92)90079-r · Cited by 1,180
An amino acid liquid synthetic medium for the development of mycellal and yeast forms ofCandida albicans
Lee, K. L., BUCKLEY, H. R., & Campbell, C. C. (1975) · Medical Mycology · doi:10.1080/00362177585190271 · Cited by 791
Suppression of Hyphal Formation in Candida albicans by Mutation of a STE12 Homolog
Liu, H., Köhler, J. R., & Fink, G. R. (1994) · Science · doi:10.1126/science.7992058 · Cited by 788
Calcineurin is required for virulence of Cryptococcus neoformans
Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2576 · Cited by 516
Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast
Stathopoulos, A. M., & Cyert, M. S. (1997) · Genes & Development · doi:10.1101/gad.11.24.3432 · Cited by 442

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Authors: Bader, T., Bodendorfer, B., Schröppel, K., & Morschhäuser, J.
Affiliations: University of Würzburg (DE)
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universität Erlangen, D-91054 Erlangen
Institut für Molekulare Infektionsbiologie, Universität Würzburg, D-97070 Würzburg
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2003-09
Volume: 71
Issue: 9
Pages: 5344-5354
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.71.9.5344-5354.2003
PMC: PMC187310
OpenAlex: W2149198831
Cited by: 121
References: 52
Citations by year: 2026: 5 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 5
FWCI: 2.07
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund
Deutsche Forschungsgemeinschaft
Bayerische Forschungsstiftung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: calcineurin, Candida albicans, virulence, systemic candidiasis, hyphal growth, cation sensitivity, temperature sensitivity, protein phosphatase, mouse model, Cryptococcus neoformans
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Candida albicans, Candidiasis, DNA, Fungal, Female, Genes, Fungal, Humans, Hydrogen-Ion Concentration, Mice, Inbred BALB C, Molecular Sequence Data, Virulence, Gene Deletion, Sequence Homology, Amino Acid, Calcineurin, Protein Subunits, Mice

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Calcineurin Is Essential for Virulence in Candida albicans

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