Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain

Bader, Teresa; Schröppel, Klaus; Bentink, Stefan; Agabian, Nina; Köhler, Gerwald; Morschhäuser, Joachim

doi:10.1128/iai.00142-06

Cited by 81Fungal and yeast genetics researchAntifungal resistance and susceptibilitySignaling Pathways in Disease

Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain

Bader, Teresa, Schröppel, Klaus, Bentink, Stefan, Agabian, Nina, Köhler, Gerwald, Morschhäuser, Joachim·2006·Infection and Immunity

DOI 10.1128/iai.00142-06

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Abstract

By generating a calcineurin mutant of the Candida albicans wild-type strain SC5314 with the help of a new recyclable dominant selection marker, we confirmed that calcineurin mediates tolerance to a variety of stress conditions but is not required for the ability of C. albicans to switch to filamentous growth in response to hypha-inducing environmental signals. While calcineurin was essential for virulence of C. albicans in a mouse model of disseminated candidiasis, deletion of CMP1 did not significantly affect virulence during vaginal or pulmonary infection, demonstrating that the requirement for calcineurin for a successful infection depends on the host niche.

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The C. glabrata Δcnb1 strain phenotype (increased susceptibility to azoles and cell wall-damaging agents, decreased virulence) is consistent with previous findings for other pathogenic fungi.
“For example, the observed C. glabrata Δcnb1 strain phenotype, which is characterized by an increased susceptibility to azoles and cell wall-damaging agents as well as decreased virulence, is consistent with previous findings for other pathogenic fungi, such as C. albicans (2-4, 27), C. neoformans (11, 18, 21), and A. fumigatus (9, 30).”
From Roles of Calcineurin and Crz1 in Antifungal Susceptibility and Virulence of Candida glabrata (2010) · cites this paper as [3]
In C. albicans, calcineurin is required for growth at both alkaline and acidic pH.
“In C. albicans, previous studies also revealed a novel requirement for calcineurin for growth at both alkaline and acidic pH (Bader et al., 2006; Kullas et al., 2007).”
From Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis (2014) · cites this paper as Bader et al., 2006

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Calcineurin Is Essential for Virulence in Candida albicans
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Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., Filler, S. G., Perfect, J. R., Blankenship, J. R., Wormley, F. L., Boyce, M. K., Schell, W. A., et al. (2003)

Authors: Bader, T., Schröppel, K., Bentink, S., Agabian, N., Köhler, G., & Morschhäuser, J.
Affiliations: University of Würzburg (DE)
Institut für Klinische Mikrobiologie, Immunologie und Hygiene, Universität Erlangen, Wasserturmstraße 3, D-91054 Erlangen, Germany
University of California, San Francisco (US)
Department of Cell and Tissue Biology, University of California, San Francisco, 521 Parnassus, San Francisco, California 94143
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2006-07
Volume: 74
Issue: 7
Pages: 4366-4369
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00142-06
OpenAlex: W2147946690
Cited by: 81
References: 18
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 5 · 2012: 7
FWCI: 2.99
Type: journal article
Language: en
Open access: closed
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai033317-08, 5r01de012940-03)
National Institute of Allergy and Infectious Diseases (AI33317)
National Institute of Dental and Craniofacial Research (DE12940)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: calcineurin, Candida albicans, stress tolerance, morphogenesis, filamentous growth, virulence, systemic candidiasis, dominant selection marker, host niche, vaginal infection, pulmonary infection
MeSH terms: Animals, Candida albicans, Candidiasis, Disease Models, Animal, Female, Immunity, Innate, Virulence, Oxidative Stress, Calcineurin, Gene Silencing, Mice

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Role of Calcineurin in Stress Resistance, Morphogenesis, and Virulence of a Candida albicans Wild-Type Strain

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