The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase
Open accessAbstract
We have cloned the REV3 gene of Saccharomyces cerevisiae by complementation of the rev3 defect in UV-induced mutagenesis. The nucleotide sequence of this gene encodes a predicted protein of Mr 172,956 showing significant sequence similarity to Epstein-Barr virus DNA polymerase and to other members of a class of DNA polymerases including human DNA polymerase alpha and yeast DNA polymerase I. REV3 protein shows less sequence identity, and presumably a more distant evolutionary relationship, to the latter two enzymes than they do to each other. Haploids carrying a complete deletion of REV3 are viable. We suggest that induced mutagenesis in S. cerevisiae depends on a specialized DNA polymerase that is not required for other replicative processes. REV3 is located 2.8 centimorgans from CDC60, on chromosome XVI.
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Metadata
- Authors
- Morrison, A., Christensen, R. B., Alley, J., Beck, A. K., Bernstine, E. G., Lemontt, J. F., & Lawrence, C. W.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1989-10
- Volume
- 171
- Issue
- 10
- Pages
- 5659-5667
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1900509644
- Cited by
- 271
- References
- 33
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Morrison, A., Christensen, R. B., Alley, J., Beck, A. K., Bernstine, E. G., Lemontt, J. F., & Lawrence, C. W. (1989). REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. Journal of Bacteriology. https://doi.org/10.1128/jb.171.10.5659-5667.1989
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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