The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation
Published version of a preprint
Abstract
The E7 oncoprotein is a primary driver of HPV-mediated carcinogenesis. HPV E7 binds the putative tumor suppressor PTPN14 and targets it for degradation using the ubiquitin ligase UBR4. PTPN14 binds to a C-terminal arginine highly conserved in diverse HPV E7. Our previous efforts to understand how PTPN14 degradation contributes to the carcinogenic activity of high-risk HPV E7 used variants of E7 unable to bind to UBR4. Now, by directly manipulating E7 binding to PTPN14 and using a PTPN14 knockout rescue experiment, we demonstrate that the degradation of PTPN14 is required for high-risk HPV18 E7 to extend keratinocyte life span. Our data show that PTPN14 binding by HPV16 E7 and HPV18 E7 represses keratinocyte differentiation. HPV-positive cancers are frequently poorly differentiated, and the HPV life cycle depends upon keratinocyte differentiation. The finding that PTPN14 binding by HPV E7 impairs differentiation has significant implications for HPV-mediated carcinogenesis and the HPV life cycle.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“suggesting that targeting PTPN14 by high-risk E7 through p600 allows E7-expressing cells to survive anoikis and proliferate, irrespective of their anchorage to the basement membrane [206,207]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [207]
In the citing paper
“several other studies have demonstrated elevated levels of EGFR at the cell surface upon HPV-16 E5 expression [101,207,208,209,210]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [207]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Selected Core Microbiome Drives the Early Stages of Three Popular Italian Cheese Manufactures
De Filippis, F., La Storia, A., Stellato, G., Gatti, M., & Ercolini, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089680 · Cited by 1,398
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Rozenblatt-Rosen, O., Deo, R. C., Padi, M., Adelmant, G., Calderwood, M. A., Rolland, T., Grace, M., Dricot, A., Askenazi, M., Tavares, M., et al. (2012) · Nature · doi:10.1038/nature11288 · Cited by 378
Self-citationWhite, E. A., Sowa, M. E., Tan, M. J. A., Jeudy, S., Hayes, S. D., Santha, S., Münger, K., Harper, J. W., & Howley, P. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116776109 · Cited by 198
Self-citationPTPN14 is required for the density-dependent control of YAP1
Wang, W., Huang, J., Wang, X., Yuan, J., Li, X., Feng, L., Park, J.-I., & Chen, J. (2012) · Genes & Development · doi:10.1101/gad.192955.112 · Cited by 195
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer
Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.007 · Cited by 179
Brimer, N., Lyons, C., Wallberg, A. E., & Vande Pol, S. B. (2012) · Oncogene · doi:10.1038/onc.2011.589 · Cited by 133
Tan, M. J. A., White, E. A., Sowa, M. E., Harper, J. W., Aster, J. C., & Howley, P. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205991109 · Cited by 132
Self-citationWilson, K. E., Li, Y.-W., Yang, N., Shen, H., Orillion, A. R., & Zhang, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.534701 · Cited by 92
Research works printed but not linked: 62
- 10.1002/ijc.30716 · DOI
- 10.3390/v9090245 · DOI
- 10.1093/nar/gks984 · DOI
- 10.1128/JVI.63.10.4417-4421.1989 · DOI · Paper page
- 10.1128/JVI.63.3.1247-1255.1989 · DOI · Paper page
- 10.1128/jvi.74.6.2679-2686.2000 · DOI
- 10.1073/pnas.97.23.12513 · DOI · Paper page
- 10.1002/j.1460-2075.1989.tb08570.x · DOI · Paper page
- 10.1128/JVI.66.12.6893-6902.1992 · DOI · Paper page
- 10.1002/j.1460-2075.1989.tb08594.x · DOI · Paper page
- 10.1128/JVI.00881-07 · DOI · Paper page
- 10.1016/0092-8674(90)90409-8 · DOI · Paper page
- 10.1126/science.2157286 · DOI · Paper page
- 10.1128/JVI.02178-19 · DOI
- 10.1128/JVI.73.9.7590-7598.1999 · DOI
- Ciccolini F, Di Pasquale G, Carlotti F, Crawford L, Tommasino M. 1994. Functional studies of E7 proteins from different HPV types. Oncogene 9:2633–2638.
- 10.1007/BF01702398 · DOI
- 10.1128/JVI.79.17.11392-11402.2005 · DOI
- 10.1128/JVI.66.3.1329-1335.1992 · DOI
- 10.1128/JVI.03282-14 · DOI
- Banks L, Edmonds C, Vousden KH. 1990. Ability of the HPV16 E7 protein to bind RB and induce DNA synthesis is not sufficient for efficient transforming activity in NIH3T3 cells. Oncogene 5:1383–1389.
- 10.1073/pnas.0505337102 · DOI · Paper page
- 10.1158/0008-5472.CAN-07-3007 · DOI
- 10.1158/0008-5472.CAN-06-0984 · DOI
- 10.1128/JVI.66.4.2418-2427.1992 · DOI · Paper page
- 10.1128/JVI.75.15.6737-6747.2001 · DOI · Paper page
- 10.1128/mBio.01530-16 · DOI · Paper page
- 10.1073/pnas.1819534116 · DOI · Paper page
- 10.1128/JVI.00057-17 · DOI · Paper page
- 10.1016/j.celrep.2018.02.095 · DOI
- 10.7554/eLife.49439 · DOI
- 10.1016/j.cell.2017.08.001 · DOI
- 10.1371/journal.pbio.3000367 · DOI
- 10.1038/340307a0 · DOI
- 10.1371/journal.pone.0100279 · DOI
- 10.1016/0092-8674(77)90058-7 · DOI
- 10.1016/j.devcel.2015.01.028 · DOI · Paper page
- 10.1016/s0042-6822(03)00390-8 · DOI
- 10.1016/j.virol.2008.09.036 · DOI
- 10.3390/v11040369 · DOI
- 10.1101/gad.1735109 · DOI
- 10.1128/JVI.65.1.473-478.1991 · DOI · Paper page
- 10.1038/ng.3525 · DOI
- 10.1073/pnas.0505322102 · DOI · Paper page
- 10.1371/journal.ppat.1006171 · DOI
- 10.1128/JVI.02527-12 · DOI
- 10.1128/JVI.02172-12 · DOI · Paper page
- 10.1042/CS20160786 · DOI
- 10.1002/rmv.1822 · DOI
- 10.1515/hsz-2017-0113 · DOI · Paper page
- 10.1128/jvi.76.20.10401-10416.2002 · DOI
- 10.1073/pnas.0707947104 · DOI
- 10.1371/journal.pbio.2005752 · DOI
- 10.1146/annurev.pathol.4.110807.092158 · DOI
- 10.1002/lary.21044 · DOI
- 10.1002/ijc.29081 · DOI
- 10.1111/ced.12227 · DOI
- Verma AK. 1987. Inhibition of both stage I and stage II mouse skin tumor promotion by retinoic acid and the dependence of inhibition of tumor promotion on the duration of retinoic acid treatment. Cancer Res 47:5092–5140.
- 10.1186/1476-4598-8-27 · DOI
- 10.1038/nbt.3437 · DOI · Paper page
- 10.1128/mcb.20.4.1436-1447.2000 · DOI · Paper page
- 10.1093/nar/gkw1138 · DOI · Paper page
Cited by
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Hatterschide, J., Brantly, A. C., Grace, M., Munger, K., & White, E. A.
- Affiliations
- Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
- Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA
- ORCID
- White, Elizabeth A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2020-08-17
- Volume
- 94
- Issue
- 17
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 33
- References
- 8
- Language
- en
- Funders
- HHS | NIH | National Cancer Institute (R01 CA066980)
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01 AI148431, T32 AI007324)
- American Cancer Society (131661-RSG-18-048-01-MPC)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation. https://app.cochat.ai/papers/10.1128/jvi.01024-20
- The paper
- Hatterschide, J., Brantly, A. C., Grace, M., Munger, K., & White, E. A. (2020). A Conserved Amino Acid in the C Terminus of Human Papillomavirus E7 Mediates Binding to PTPN14 and Repression of Epithelial Differentiation. Journal of Virology. https://doi.org/10.1128/jvi.01024-20
