The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Kaposi's Sarcoma-Associated Herpesvirus Encodes an Ortholog of miR-155
Open accessAbstract
MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by binding to 3′-untranslated regions (3′UTRs) of target mRNAs. Kaposi's sarcoma-associated herpesvirus (KSHV), a virus linked to malignancies including primary effusion lymphoma (PEL), encodes 12 miRNA genes, but only a few regulatory targets are known. We found that KSHV-miR-K12-11 shares 100% seed sequence homology with hsa-miR-155, an miRNA frequently found to be up-regulated in lymphomas and critically important for B-cell development. Based on this seed sequence homology, we hypothesized that both miRNAs regulate a common set of target genes and, as a result, could have similar biological activities. Examination of five PEL lines showed that PELs do not express miR-155 but do express high levels of miR-K12-11. Bioinformatic tools predicted the transcriptional repressor BACH-1 to be targeted by both miRNAs, and ectopic expression of either miR-155 or miR-K12-11 inhibited a BACH-1 3′UTR-containing reporter. Furthermore, BACH-1 protein levels are low in cells expressing either miRNA. Gene expression profiling of miRNA-expressing stable cell lines revealed 66 genes that were commonly down-regulated. For select genes, miRNA targeting was confirmed by reporter assays. Thus, based on our in silico predictions, reporter assays, and expression profiling data, miR-K12-11 and miR-155 regulate a common set of cellular targets. Given the role of miR-155 during B-cell maturation, we speculate that miR-K12-11 may contribute to the distinct developmental phenotype of PEL cells, which are blocked in a late stage of B-cell development. Together, these findings indicate that KSHV miR-K12-11 is an ortholog of miR-155.
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Cites
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Self-citationAn Epstein-Barr virus–encoded microRNA targets PUMA to promote host cell survival
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Metadata
- Authors
- Skalsky, R. L., Samols, M. A., Plaisance, K. B., Boss, I. W., Riva, A., Lopez, M. C., Baker, H. V., & Renne, R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-12
- Volume
- 81
- Issue
- 23
- Pages
- 12836-12845
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2142798790
- Cited by
- 445
- References
- 10
- FWCI
- 19.62
- Type
- journal article
- Language
- en
- Open access
- green
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