The DOI matches its Crossref record.
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection
Open accessAbstract
Human immunodeficiency virus type 1 (HIV-1) Env-, Gag-, Pol-, Nef-, and Tat-specific cytotoxic T-lymphocyte (CTL) activities were quantitated temporally in five patients with symptomatic primary HIV-1 infection. A dominant CD8(+)-mediated, major histocompatibility complex class I-restricted CTL response to the HIV-1 envelope glycoprotein, gp160, was noted in four of the five patients studied. The level of HIV-1-specific CTL activity in the five patients paralleled the efficiency of control of primary viremia. Patients who mounted strong gp160-specific CTL responses showed rapid reduction of acute plasma viremia and antigenemia, while in contrast, primary viremia and antigenemia were poorly controlled in patients in whom virus-specific CTL activity was low or undetectable. These results suggest that HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Pollack, R. A., Jones, R. B., Pertea, M., Bruner, K. M., Martin, A. R., Thomas, A. S., Capoferri, A. A., Beg, S. A., Huang, S.-H., Karandish, S., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.008 · Cited by 370
The role of CD8+ T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336
Perri, S., Greer, C. E., Thudium, K., Doe, B., Legg, H., Liu, H., Romero, R. E., Tang, Z., Bin, Q., Dubensky, T. W., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.19.10394-10403.2003 · Cited by 172
Reynolds, M. R., Rakasz, E., Skinner, P. J., White, C., Abel, K., Ma, Z.-M., Compton, L., Napoé, G., Wilson, N., Miller, C. J., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.9228-9235.2005 · Cited by 168
Increased CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
Mueller, Y. M., De Rosa, S. C., Hutton, J. A., Witek, J., Roederer, M., Altman, J. D., & Katsikis, P. D. (2001) · Immunity · doi:10.1016/s1074-7613(01)00246-1 · Cited by 164
Kinetics of Virus-Specific CD8+T Cells and the Control of Human Immunodeficiency Virus Infection
Davenport, M. P., Ribeiro, R. M., & Perelson, A. S. (2004) · Journal of Virology · doi:10.1128/jvi.78.18.10096-10103.2004 · Cited by 101
Moyo, N., Vogel, A. B., Buus, S., Erbar, S., Wee, E. G., Sahin, U., & Hanke, T. (2019) · Molecular Therapy - Methods & Clinical Development · doi:10.1016/j.omtm.2018.10.010 · Cited by 94
Colven, R., Harrington, R. D., Spach, D. H., Cohen, C. J., & Hooton, T. M. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-6-200009190-00010 · Cited by 63
Takeda, A., Igarashi, H., Kawada, M., Tsukamoto, T., Yamamoto, H., Inoue, M., Iida, A., Shu, T., Hasegawa, M., & Matano, T. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.09.074 · Cited by 28
Manoussaka, M. S., Berry, N., Ferguson, D., Stebbings, R., Robinson, M., Ham, C., Page, M., Li, B., Das, A. T., Berkhout, B., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-59 · Cited by 16
Metadata
- Authors
- Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M., & Oldstone, M. B.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-09
- Volume
- 68
- Issue
- 9
- Pages
- 6103-6110
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2103182811
- Cited by
- 1,882
- References
- 0
- FWCI
- 17.71
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
