The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis
Open accessAbstract
Identification of T-cell subsets that are infected in vivo is essential to understanding the pathogenesis of human immunodeficiency virus (HIV) disease; however, this goal has been beset with technical challenges. Here, we used polychromatic flow cytometry to sort multiple T-cell subsets to 99.8% purity, followed by quantitative PCR to quantify HIV gag DNA directly ex vivo. We show that resting memory CD4+T cells are the predominantly infected cells but that terminally differentiated memory CD4+T cells contain 10-fold fewer copies of HIV DNA. Memory CD8+T cells can also be infected upon upregulation of CD4; however, this is infrequent and HIV-specific CD8+T cells are not infected preferentially. Naïve CD4+T-cell infection is rare and principally confined to those peripheral T cells that have proliferated. Furthermore, the virus is essentially absent from naïve CD8+T cells, suggesting that the thymus is not a major source of HIV-infected T cells in the periphery. These data illuminate the underlying mechanisms that distort T-cell homeostasis in HIV infection.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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HIV preferentially infects HIV-specific CD4+ T cells
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Self-citationBrenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073
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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
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Self-citationLifespan of human lymphocyte subsets defined by CD45 isoforms
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Cited by
Redefining the Viral Reservoirs that Prevent HIV-1 Eradication
Eisele, E., & Siliciano, R. F. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.010 · Cited by 474
HIV‐associated chronic immune activation
Paiardini, M., & Müller‐Trutwin, M. (2013) · Immunological Reviews · doi:10.1111/imr.12079 · Cited by 451
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
Bosque, A., & Planelles, V. (2009) · Blood · doi:10.1182/blood-2008-07-168393 · Cited by 340
Fundamentals and application of magnetic particles in cell isolation and enrichment: a review
Plouffe, B. D., Murthy, S. K., & Lewis, L. H. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/1/016601 · Cited by 334
Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., Adelmann, K., Kang, Y.-H., Fergusson, J. R., Simmonds, P., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436436 · Cited by 316
Metadata
- Authors
- Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Price, D. A., Guenaga, F. J., Casazza, J. P., Kuruppu, J., Yazdani, J., Migueles, S. A., Connors, M., Roederer, M., Douek, D. C., & Koup, R. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2004-02
- Volume
- 78
- Issue
- 3
- Pages
- 1160-1168
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2158676450
- Cited by
- 384
- References
- 47
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- green
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- Brenchley, J. M., Hill, B. J., Ambrozak, D. R., Price, D. A., Guenaga, F. J., Casazza, J. P., Kuruppu, J., Yazdani, J., Migueles, S. A., Connors, M., Roederer, M., Douek, D. C., & Koup, R. A. (2004). T-Cell Subsets That Harbor Human Immunodeficiency Virus (HIV) In Vivo: Implications for HIV Pathogenesis. Journal of Virology. https://doi.org/10.1128/jvi.78.3.1160-1168.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
