The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Castanospermine, a Potent Inhibitor of Dengue Virus Infection In Vitro and In Vivo
Open accessAbstract
Previous studies have suggested that α-glucosidase inhibitors such as castanospermine and deoxynojirimycin inhibit dengue virus type 1 infection by disrupting the folding of the structural proteins prM and E, a step crucial to viral secretion. We extend these studies by evaluating the inhibitory activity of castanospermine against a panel of clinically important flaviviruses including all four serotypes of dengue virus, yellow fever virus, and West Nile virus. Using in vitro assays we demonstrated that infections by all serotypes of dengue virus were inhibited by castanospermine. In contrast, yellow fever virus and West Nile virus were partially and almost completely resistant to the effects of the drug, respectively. Castanospermine inhibited dengue virus infection at the level of secretion and infectivity of viral particles. Importantly, castanospermine prevented mortality in a mouse model of dengue virus infection, with doses of 10, 50, and 250 mg/kg of body weight per day being highly effective at promoting survival (P≤ 0.0001). Correspondingly, castanospermine had no adverse or protective effect on West Nile virus mortality in an analogous mouse model. Overall, our data suggest that castanospermine has a strong antiviral effect on dengue virus infection and warrants further development as a possible treatment in humans.
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Cited by
An adenosine nucleoside inhibitor of dengue virus
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Discovery of insect and human dengue virus host factors
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Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
Boldescu, V., Behnam, M. A. M., Vasilakis, N., & Klein, C. D. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.33 · Cited by 305
Strategies for development of dengue virus inhibitors
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Self-citation
Metadata
- Authors
- Whitby, K., Pierson, T. C., Geiss, B., Lane, K., Engle, M., Zhou, Y., Doms, R. W., & Diamond, M. S.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2005-07
- Volume
- 79
- Issue
- 14
- Pages
- 8698-8706
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2159415883
- Cited by
- 295
- References
- 49
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Whitby, K., Pierson, T. C., Geiss, B., Lane, K., Engle, M., Zhou, Y., Doms, R. W., & Diamond, M. S. (2005). Castanospermine, a Potent Inhibitor of Dengue Virus Infection In Vitro and In Vivo. Journal of Virology. https://doi.org/10.1128/jvi.79.14.8698-8706.2005
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