Cited by 300Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesVirology and Viral Diseases

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Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.

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Nugent, J., Birch-Machin, I., Smith, K. C., Mumford, J. A., Swann, Z., Newton, J. R., Bowden, R. J., Allen, G. P., Davis-Poynter, N.·2006·Journal of Virology

DOI 10.1128/jvi.80.8.4047-4060.2006PMC PMC1440451

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Abstract

Equid herpesvirus 1 (EHV-1) can cause a wide spectrum of diseases ranging from inapparent respiratory infection to the induction of abortion and, in extreme cases, neurological disease resulting in paralysis and ultimately death. It has been suggested that distinct strains of EHV-1 that differ in pathogenic capacity circulate in the field. In order to investigate this hypothesis, it was necessary to identify genetic markers that allow subgroups of related strains to be identified. We have determined all of the genetic differences between a neuropathogenic strain (Ab4) and a nonneuropathogenic strain (V592) of EHV-1 and developed PCR/sequencing procedures enabling differentiation of EHV-1 strains circulating in the field. The results indicate the occurrence of several major genetic subgroups of EHV-1 among isolates recovered from outbreaks over the course of 30 years, consistent with the proposal that distinct strains of EHV-1 circulate in the field. Moreover, there is evidence that certain strain groups are geographically restricted, being recovered predominantly from outbreaks occurring in either North America or Europe. Significantly, variation of a single amino acid of the DNA polymerase is strongly associated with neurological versus nonneurological disease outbreaks. Strikingly, this variant amino acid occurs at a highly conserved position for herpesvirus DNA polymerases, suggesting an important functional role.

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BIOEDIT: A USER-FRIENDLY BIOLOGICAL SEQUENCE ALIGNMENT EDITOR AND ANALYSIS PROGRAM FOR WINDOWS 95/98/ NT
Hall, T. A. (1999) · Nucleic Acids Symposium Series · doi:10.14601/phytopathol_mediterr-14998u1.29 · Cited by 38,156
MEGA2: molecular evolutionary genetics analysis software
Kumar, S., Tamura, K., Jakobsen, I. B., & Nei, M. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.12.1244 · Cited by 6,046
A fluorimetric method for the estimation of G + C mol% content in microorganisms by thermal denaturation temperature
Grau, J. M. G., & Sáiz‐Jiménez, C. (2002) · Environmental Microbiology · doi:10.1046/j.1462-2920.2002.00362.x · Cited by 1,707
The staden sequence analysis package
Staden, R. (1996) · Molecular Biotechnology · doi:10.1007/bf02900361 · Cited by 1,264
Mitochondrial portraits of human populations using median networks.
Bandelt, H. J., Forster, P., Sykes, B. C., & Richards, M. B. (1995) · Genetics · doi:10.1093/genetics/141.2.743 · Cited by 1,071
The DNA sequence of equine herpesvirus-1
Telford, E. A. R., Watson, M. S., McBride, K. R., & Davison, A. J. (1992) · Virology · doi:10.1016/0042-6822(92)90706-u · Cited by 650
Analysis of the complete DNA sequence of murine cytomegalovirus
Rawlinson, W. D., Farrell, H. E., & BARRELL, B. G. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8833-8849.1996 · Cited by 593
EUKARYOTIC DNA POLYMERASES
Wang, T. S. ‐. (1991) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.60.070191.002501 · Cited by 483
Equine Infectious Diseases
(2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-2406-4.x5001-7 · Cited by 350
Analysis of Interstrain Variation in Cytomegalovirus Glycoprotein B Sequences Encoding Neutralization-Related Epitopes
Chou, S., & Dennison, K. M. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.6.1229 · Cited by 342

Show all 60 references

Research works printed but not linked: 5

Bass, E. P. 1979. Immunization with a modified live virus equine rhinopneumonitis vaccine and an aluminum hydroxide absorbed equine influenza vaccine. Proc. Am. Assoc. Equine Pract.24:65-74.
Beckenaur, W. H., and E. P. Bass. 1973. A modified live virus vaccine for equine rhinopneumonitis. J. Am. Vet. Med. Assoc.163:1182.
Blunden, A. S., K. E. Whitwell, and K. M. Pegler. 1993. An outbreak of paralysis associated with equine herpes virus type 1 infection in a livery stable. Prog. Vet. Neurol.3:95-100.
Mumford, J. A., and N. Edington. 1980. EHV-1 and equine paresis. Vet. Rec.106:277.
Mumford, J. A., D. Hannant, D. M. Jessett, T. O'Neill, K. C. Smith, and E. N. Ostlund. 1994. Abortigenic and neurological disease caused by experimental infection with equid herpesvirus-1, p. 261-275. In H. Nakajima and W. Plowright (ed.), Equine infectious diseases VII. Proceedings of the Seventh International Conference on Equine Infectious Diseases. R&W Publications, Newmarket, United Kingdom.

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Authors: Nugent, J., Birch-Machin, I., Smith, K. C., Mumford, J. A., Swann, Z., Newton, J. R., Bowden, R. J., Allen, G. P., & Davis-Poynter, N.
Affiliations: Animal Health Trust (GB)
Animal Health Trust, Kentford, Newmarket, United Kingdom
University of Oxford (GB)
University of Kentucky (US)
Corresponding author: Davis-Poynter, N.
ORCID: Newton, J. R.
Bowden, R. J.
Allen, G. P.
Davis-Poynter, N.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2006-04-15
Volume: 80
Issue: 8
Pages: 4047-4060
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.80.8.4047-4060.2006
PMC: PMC1440451
OpenAlex: W2167022679
Cited by: 295
References: 60
Citations by year: 2026: 2 · 2025: 13 · 2024: 14 · 2023: 9 · 2022: 15 · 2021: 20 · 2020: 14 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 11 · 2015: 15 · 2014: 14 · 2013: 15 · 2012: 15
FWCI: 10.74
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: equine herpesvirus 1, neurovirulence, genetic subgroups, strain differentiation, neurological disorders, equine herpesvirus
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Disease Outbreaks, DNA-Directed DNA Polymerase, Herpesvirus 1, Equid, Horse Diseases, Horses, Molecular Sequence Data, Open Reading Frames, Point Mutation, Polymorphism, Single Nucleotide

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Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.

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