Cited by 300Herpesvirus Infections and TreatmentsAnimal Virus Infections StudiesVirology and Viral Diseases

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Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.

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Nugent, J., Birch-Machin, I., Smith, K. C., Mumford, J. A., Swann, Z., Newton, J. R., Bowden, R. J., Allen, G. P., Davis-Poynter, N.·2006·Journal of Virology

DOI 10.1128/jvi.80.8.4047-4060.2006PMC PMC1440451

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Abstract

Equid herpesvirus 1 (EHV-1) can cause a wide spectrum of diseases ranging from inapparent respiratory infection to the induction of abortion and, in extreme cases, neurological disease resulting in paralysis and ultimately death. It has been suggested that distinct strains of EHV-1 that differ in pathogenic capacity circulate in the field. In order to investigate this hypothesis, it was necessary to identify genetic markers that allow subgroups of related strains to be identified. We have determined all of the genetic differences between a neuropathogenic strain (Ab4) and a nonneuropathogenic strain (V592) of EHV-1 and developed PCR/sequencing procedures enabling differentiation of EHV-1 strains circulating in the field. The results indicate the occurrence of several major genetic subgroups of EHV-1 among isolates recovered from outbreaks over the course of 30 years, consistent with the proposal that distinct strains of EHV-1 circulate in the field. Moreover, there is evidence that certain strain groups are geographically restricted, being recovered predominantly from outbreaks occurring in either North America or Europe. Significantly, variation of a single amino acid of the DNA polymerase is strongly associated with neurological versus nonneurological disease outbreaks. Strikingly, this variant amino acid occurs at a highly conserved position for herpesvirus DNA polymerases, suggesting an important functional role.

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Authors: Nugent, J., Birch-Machin, I., Smith, K. C., Mumford, J. A., Swann, Z., Newton, J. R., Bowden, R. J., Allen, G. P., & Davis-Poynter, N.
Affiliations: Animal Health Trust (GB)
Animal Health Trust, Kentford, Newmarket, United Kingdom
University of Oxford (GB)
University of Kentucky (US)
Corresponding author: Davis-Poynter, N.
ORCID: Newton, J. R.
Bowden, R. J.
Allen, G. P.
Davis-Poynter, N.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2006-04-15
Volume: 80
Issue: 8
Pages: 4047-4060
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.80.8.4047-4060.2006
PMC: PMC1440451
OpenAlex: W2167022679
Cited by: 295
References: 60
Citations by year: 2026: 2 · 2025: 13 · 2024: 14 · 2023: 9 · 2022: 15 · 2021: 20 · 2020: 14 · 2019: 23 · 2018: 11 · 2017: 20 · 2016: 11 · 2015: 15 · 2014: 14 · 2013: 15 · 2012: 15
FWCI: 10.74
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: equine herpesvirus 1, neurovirulence, genetic subgroups, strain differentiation, neurological disorders, equine herpesvirus
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Disease Outbreaks, DNA-Directed DNA Polymerase, Herpesvirus 1, Equid, Horse Diseases, Horses, Molecular Sequence Data, Open Reading Frames, Point Mutation, Polymorphism, Single Nucleotide

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Analysis of equid herpesvirus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus nonneuropathogenic disease outbreaks.

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