Equid Herpesvirus 1 targets the sensitization and induction steps to inhibit the type I interferon response in equine endothelial cells.
Open accessAbstract
To date, no commercial vaccine label has a claim to be fully protective against the diseases caused by equid herpesvirus 1 (EHV-1), especially the neurologic form. The interferon (IFN) system, of which type I IFN is of great importance, still remains a viable immunotherapeutic option against EHV-1 infection. The type I IFN system has been exploited successfully to treat other viral infections, such as chronic hepatitis B and C in humans. The current state of research on how EHV-1 interferes with the protective effect of type I IFN has indicated transient induction of type I IFN production followed by a rapid shutdownin vitroin equine endothelial cells (EECs). The significance of our study is the identification of certain steps in the type I IFN signaling pathway targeted for inhibition by EHV-1. Understanding this pathogen-host relationship is essential for the long-term goal of developing effective immunotherapy against EHV-1.
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EHV-1 disrupts the JAK/STAT signaling pathway by degrading cellular levels of TYK2 and downregulates downstream STAT1 and STAT2 phosphorylation levels.
“The virus also disrupts the JAK/STAT signaling pathway by degrading cellular levels of TYK2 and thus, downregulates downstream STAT1 and STAT2 phosphorylation levels (Sarkar et al., 2016b; Oladunni et al., 2019).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Oladunni et al., 2019
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Gordon, S., Pusterla, N., Finno, C. J., Young, A. E., & Martínez‐López, B. (2026) · Veterinary Sciences · doi:10.3390/vetsci13020121 · Cited by 1 · see citing works
Immunity to selected equine viruses
Tizard, I. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44863-8.00029-6
- Authors
- Oladunni, F. S., Sarkar, S., Reedy, S., Balasuriya, U. B. R., Horohov, D. W., & Chambers, T. M.
- Affiliations
- University of Ilorin (NG)
- University of Kentucky (US)
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2019-12
- Volume
- 93
- Issue
- 23
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC6854505
- OpenAlex
- W2972495303
- Cited by
- 18
- References
- 80
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- Geoffrey C. Hughes Foundation
- Kentucky Horse Racing Commission
- American Quarter Horse Association
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- equine herpesvirus 1, type I interferon, interferon pathway, immunotherapy, host-pathogen interaction, equine infectious diseases
- MeSH terms
- Animals, Herpesvirus 1, Equid, Gene Expression Regulation, Herpesviridae Infections, Horse Diseases, Horses, Humans, Immunity, Innate, Interferon Type I, RNA, Messenger, Signal Transduction, Hepatitis B, Chronic, Endothelial Cells, STAT2 Transcription Factor, Toll-Like Receptor 3, Toll-Like Receptor 4, Janus Kinase 1, TYK2 Kinase, Host-Pathogen Interactions
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