Cited by 18interferon and immune responsesHerpesvirus Infections and TreatmentsAnimal Virus Infections Studies

Equid Herpesvirus 1 targets the sensitization and induction steps to inhibit the type I interferon response in equine endothelial cells.

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Oladunni, Fatai S., Sarkar, Sanjay, Reedy, Stephanie, Balasuriya, Udeni B. R., Horohov, David W., Chambers, Thomas M.·2019·Journal of Virology

Abstract

To date, no commercial vaccine label has a claim to be fully protective against the diseases caused by equid herpesvirus 1 (EHV-1), especially the neurologic form. The interferon (IFN) system, of which type I IFN is of great importance, still remains a viable immunotherapeutic option against EHV-1 infection. The type I IFN system has been exploited successfully to treat other viral infections, such as chronic hepatitis B and C in humans. The current state of research on how EHV-1 interferes with the protective effect of type I IFN has indicated transient induction of type I IFN production followed by a rapid shutdownin vitroin equine endothelial cells (EECs). The significance of our study is the identification of certain steps in the type I IFN signaling pathway targeted for inhibition by EHV-1. Understanding this pathogen-host relationship is essential for the long-term goal of developing effective immunotherapy against EHV-1.

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Crossref · 10.1128/jvi.01342-19

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  • EHV-1 disrupts the JAK/STAT signaling pathway by degrading cellular levels of TYK2 and downregulates downstream STAT1 and STAT2 phosphorylation levels.

    “The virus also disrupts the JAK/STAT signaling pathway by degrading cellular levels of TYK2 and thus, downregulates downstream STAT1 and STAT2 phosphorylation levels (Sarkar et al., 2016b; Oladunni et al., 2019).”

    From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Oladunni et al., 2019

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Authors
Oladunni, F. S., Sarkar, S., Reedy, S., Balasuriya, U. B. R., Horohov, D. W., & Chambers, T. M.
Affiliations
  • University of Ilorin (NG)
  • University of Kentucky (US)
Venue
Journal of Virology
Published
2019-12
Volume
93
Issue
23
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2972495303
Cited by
18
References
80
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1
FWCI
0.80
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Civil War Book Review (submittedVersion)
Funders
  • Geoffrey C. Hughes Foundation
  • Kentucky Horse Racing Commission
  • American Quarter Horse Association
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
equine herpesvirus 1, type I interferon, interferon pathway, immunotherapy, host-pathogen interaction, equine infectious diseases
MeSH terms
Animals, Herpesvirus 1, Equid, Gene Expression Regulation, Herpesviridae Infections, Horse Diseases, Horses, Humans, Immunity, Innate, Interferon Type I, RNA, Messenger, Signal Transduction, Hepatitis B, Chronic, Endothelial Cells, STAT2 Transcription Factor, Toll-Like Receptor 3, Toll-Like Receptor 4, Janus Kinase 1, TYK2 Kinase, Host-Pathogen Interactions

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