The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LDLR and its family members such as VLDLR, apoER, and LRP1 undergo ectodomain shedding to release soluble forms into extracellular fluids such as cerebrospinal fluid and blood.
“LDLR and its family members such as VLDLR, apoER and LRP1 undergo ectodomain shedding to release their soluble forms into the extracellular milieu such as cerebrospinal fluid and blood12,29,30.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [29]
The Results section ('Presence of sVLDLR-N in CM from RPE cells and IPM'; page unavailable) reports that VLDLR undergoes ectodomain shedding. The Discussion (page unavailable) reports soluble VLDLR in mouse and human plasma. The cited paper does not establish the same claim for LDLR, apoER, or LRP1, or report soluble forms in cerebrospinal fluid. (LLM, conf=0.87)
Experimental — accuracy not yet measuredsVLDLR is naturally present in the interphotoreceptor matrix (IPM).
“Previously, we showed that soluble N-terminal ectodomain of VLDLR (sVLDLR) is naturally present in the interphotoreceptor matrix (IPM), the extracellular matrix between the photoreceptors and retinal pigment epithelium (RPE) (10).”
From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [10]
VLDLRII demonstrates a more potent Wnt inhibitory effect than VLDLRI.
“and thus demonstrates a more potent Wnt inhibitory effect (10).”
From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [10]
The shed ectodomains of VLDLR and apoER contain the ligand-binding domain and can bind Reelin, functioning as a competitive negative regulator to block Reelin binding to cell surface receptors.
“The shed ectodomains of VLDLR and apoER contain the ligand-binding domain and can bind to their ligand, Reelin, functioning as a competitive negative regulator to block binding of Reelin to the cell surface receptors29,30,40.”
From Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis (2021) · cites this paper as [29]
VLDLRII lacks the O-linked sugar domain encoded by exon 16 and confers a higher ectodomain shedding rate than VLDLRI.
“VLDLRII lacks the O-linked sugar domain encoded by exon 16 and confers a higher ectodomain shedding rate than VLDLRI”
From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [10]
The retina expresses exclusively VLDLRII.
“While most tissues, such as the brain, kidney, and skeletal muscle, express both VLDLRI and VLDLRII, the retina expresses exclusively VLDLRII (10)”
From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [10]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Garton, K. J., Gough, P. J., Philalay, J., Wille, P. T., Blobel, C. P., Whitehead, R. H., Dempsey, P. J., & Raines, E. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305877200 · Cited by 282
Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35977 · Cited by 127
Sakai, K., Tiebel, O., Ljungberg, M. C., Sullivan, M., Lee, H.-J., Terashima, T., Li, R., Kobayashi, K., Lu, H.-C., Chan, L., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.030 · Cited by 23
Self-citation
Flagged first, then by citations
Research works printed but not linked: 48
- 10.1016/j.devcel.2009.06.016 · DOI · Paper page
- 10.1016/j.cell.2012.05.012 · DOI · Paper page
- 10.1161/CIRCRESAHA.110.223768 · DOI
- 10.1161/HYPERTENSIONAHA.109.141127 · DOI
- 10.2353/ajpath.2009.080945 · DOI
- 10.1007/s00125-011-2314-2 · DOI
- 10.1515/bc.2010.129 · DOI
- 10.1146/annurev.nutr.19.1.141 · DOI
- 10.2741/Argraves · DOI · Paper page
- 10.1038/nrn1113 · DOI
- 10.1074/jbc.M611289200 · DOI · Paper page
- 10.1073/pnas.92.18.8453 · DOI · Paper page
- 10.1167/iovs.07-0870 · DOI · Paper page
- 10.1001/archopht.125.6.795 · DOI
- 10.1167/iovs.08-2447 · DOI
- Lee K, 2014, J Cell Sci, 127, 4857
- 10.1093/oxfordjournals.jbchem.a022175 · DOI
- 10.3748/wjg.v11.i18.2817 · DOI
- 10.1016/j.lfs.2008.12.020 · DOI
- 10.1038/344070a0 · DOI
- Becker JC, 1991, Functional consequences on cell-mediated cytotoxicity. J Immunol, 147, 4398
- 10.1182/blood.V98.6.1904 · DOI
- 10.1016/S0014-5793(99)00494-9 · DOI
- 10.1016/j.pep.2011.02.008 · DOI
- 10.1006/prep.1995.1060 · DOI
- 10.1038/jid.2014.40 · DOI
- 10.1016/j.febslet.2015.03.010 · DOI
- 10.1167/iovs.12-10921 · DOI
- 10.1161/ATVBAHA.114.304627 · DOI · Paper page
- 10.1128/JVI.72.12.10246-10250.1998 · DOI
- 10.1128/MCB.22.4.1184-1193.2002 · DOI
- 10.1016/0092-8674(86)90841-X · DOI
- 10.1042/BJ20111377 · DOI
- 10.2174/157339911797415620 · DOI
- 10.2337/diabetes.53.11.2931 · DOI
- 10.1172/JCI4431 · DOI
- 10.2337/diab.46.5.887 · DOI
- 10.1126/science.271.5251.994 · DOI
- 10.1161/CIRCULATIONAHA.111.040337 · DOI
- 10.1186/1750-1326-4-17 · DOI · Paper page
- 10.1083/jcb.128.3.433 · DOI
- 10.1074/jbc.272.27.17160 · DOI
- 10.3389/fncel.2014.00017 · DOI
- 10.1038/ncb2102 · DOI
- 10.1167/iovs.04-1340 · DOI
- Midena E, 1989, Endothelial cell-pericyte ratio. Ophthalmic Res, 21, 106
- 10.1016/S0014-4835(03)00155-6 · DOI
- 10.1161/01.ATV.16.3.407 · DOI
Cited by
Sorted by citations
Alabi, A., Xia, X.-D., Gu, H.-M., Wang, F., Deng, S.-J., Yang, N., Adijiang, A., Douglas, D. N., Kneteman, N. M., Xue, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22167-3 · Cited by 63
ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium
Ma, X., Takahashi, Y., Wu, W., Liang, W., Chen, J., Chakraborty, D., Li, Y., Du, Y., Benyajati, S., & Ma, J.-X. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101185 · Cited by 9
Self-citation
Metadata
- Authors
- Chen, Q., Takahashi, Y., Oka, K., & Ma, J.-X.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2016-10-01
- Volume
- 36
- Issue
- 20
- Pages
- 2645-2654
- ISSN
- 1098-5549
- PMC
- PMC5038150
- Cited by
- 17
- References
- 3
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
